Professor, Internal Medicine, Washington University School of Medicine
Rheumatology
Dr. Wayne M. Yokoyama, MD
Dr. Wayne M. Yokoyama is an expert in the field of Rheumatology. He researched medicine at University of Hawaii John A. Burns School of Medicine. University of Hawaii John A. Burns School of Medicine has a rank of 74 in research and a 19 in primary care He over the years received 6 awards: "Elected Member", "Investigator Alumnus", "Investigator", "Fellow (FACR)", "Fellow" and "Whos Who in Medicine and Healthcare". Wayne Yokoyama is a published physician as well. He has 93 publications published. The latest was: Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody.
Publications
- Runx3 specifies lineage commitment of innate lymphoid cells.
- Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody.
- Chikungunya viral arthritis in the United States: a mimic of seronegative rheumatoid arthritis.
- Tissue-resident natural killer cells and their potential diversity.
- Tissue-Resident Natural Killer Cells.
- Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation.
- Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.
- Natural killer cell licensing in mice with inducible expression of MHC class I.
- Natural killer cells in human autoimmune disorders.
- Cowpox virus employs a two-pronged strategy to outflank MHCI antigen presentation.
- Interferon-? mediates chemokine-dependent recruitment of natural killer cells during viral infection.
- Inositol tetrakisphosphate limits NK cell effector functions by controlling PI3K signaling.
- A Temporal Role Of Type I Interferon Signaling in CD8 T Cell Maturation during Acute West Nile Virus Infection.
- Development of thymic NK cells from double-negative 1 thymocyte precursors.
- Unifying concepts of MHC-dependent natural killer cell education.
- Ly49-dependent NK cell licensing and effector inhibition involve the same interaction site on MHC ligands.
- Innate or adaptive immunity? The example of natural killer cells.
- MHC class I-deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I-sufficient environment.
- Murine trophoblast cells induce NK cell interferon-gamma production through KLRK1.
- Effects of MHC class I alleles on licensing of Ly49A+ NK cells.
- Stability of murine cytomegalovirus genome after in vitro and in vivo passage.
- Natural killer cells: tolerance to self and innate immunity to viral infection and malignancy.
- Contrasting roles of the IL-1 and IL-18 receptors in MyD88-dependent contact hypersensitivity.
- Assessing licensing of NK cells.
- Two mechanistically distinct immune evasion proteins of cowpox virus combine to avoid antiviral CD8 T cells.
- Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice.
- Cytokine-induced memory-like natural killer cells.
- Natural killer cell tolerance licensing and other mechanisms.
- Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator.
- Inhibitory receptors signal activation.
- Ly49h is necessary for genetic resistance to murine cytomegalovirus.
- Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production.
- Distal-less homeobox transcription factors regulate development and maturation of natural killer cells.
- Continuous engagement of a self-specific activation receptor induces NK cell tolerance.
- Production of monoclonal antibody supernatant and ascites fluid.
- Ly49H+ NK cells migrate to and protect splenic white pulp stroma from murine cytomegalovirus infection.
- Mistaken notions about natural killer cells.
- Regulation of the NK cell alloreactivity to bone marrow cells by the combination of the host NK gene complex and MHC haplotypes.
- HLA alleles determine differences in human natural killer cell responsiveness and potency.
- Analysis of individual natural killer cell responses.
- Cowpox virus exploits the endoplasmic reticulum retention pathway to inhibit MHC class I transport to the cell surface.
- Hierarchy of the human natural killer cell response is determined by class and quantity of inhibitory receptors for self-HLA-B and HLA-C ligands.
- Chronic lymphocytosis of functionally immature natural killer cells.
- Critical negative regulation of type 1 T cell immunity and immunopathology by signaling adaptor DAP12 during intracellular infection.
- Mechanisms involved in synergistic anticancer immunity of anti-4-1BB and anti-CD4 therapy.
- Zoonotic orthopoxviruses encode a high-affinity antagonist of NKG2D.
- Induction of natural killer cell responses by ectromelia virus controls infection.
- MHC Class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells. Nature 358: 66-70, 1992.
- DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections.
- IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferation.
- Production of monoclonal antibodies.
- NK cells use NKG2D to recognize a mouse renal cancer (Renca), yet require intercellular adhesion molecule-1 expression on the tumor cells for optimal perforin-dependen...
- Contact hypersensitivity: not just T cells!
- How do natural killer cells find self to achieve tolerance?
- Arrested natural killer cell development associated with transgene insertion into the Atf2 locus.
- IFN-dependent down-regulation of the NKG2D ligand H60 on tumors.
- Expression of m157, a murine cytomegalovirus-encoded putative major histocompatibility class I (MHC-I)-like protein, is independent of viral regulation of host MHC-I.
- NKG2D function protects the host from tumor initiation.
- Costimulation through NKG2D enhances murine CD8+ CTL function: similarities and differences between NKG2D and CD28 costimulation.
- NKG2D-independent suppression of T cell proliferation by H60 and MICA.
- Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo.
- Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors.
- Rapid emergence of escape mutants following infection with murine cytomegalovirus in immunodeficient mice.
- Natural killer cells utilize both perforin and gamma interferon to regulate murine cytomegalovirus infection in the spleen and liver.
- Specific and non-specific natural killer cell responses to viral infection.
- Natural killer cell immune responses.
- Rat NKp46 activates natural killer cell cytotoxicity and is associated with FcepsilonRIgamma and CD3zeta.
- NKG2D recognition and perforin effector function mediate effective cytokine immunotherapy of cancer.
- Role of natural killer cells in innate protection against lethal ebola virus infection.
- Gain of virulence caused by loss of a gene in murine cytomegalovirus.
- TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function.
- Escape of mutant double-stranded DNA virus from innate immune control.
- Betting on NKT and NK cells.
- Coordinate expression of cytokines and chemokines by NK cells during murine cytomegalovirus infection.
- The dynamic life of natural killer cells.
- Natural killer cells and autoimmunity.
- Murine cytomegalovirus m157 mutation and variation leads to immune evasion of natural killer cells.
- Molecular genetic characterization of the distal NKC recombination hotspot and putative murine CMV resistance control locus.
- Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors.
- The gp49B1 inhibitory receptor regulates the IFN-gamma responses of T cells and NK cells.
- Functional interactions between dendritic cells and NK cells during viral infection.
- Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice.
- NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation.
- Cutting edge: murine UL16-binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D.
- Costimulation of multiple NK cell activation receptors by NKG2D.
- Flow cytometry analysis using the Becton Dickinson FACS Calibur.
- A ligand for the murine NK activation receptor Ly-49D: activation of tolerized NK cells from beta 2-microglobulin-deficient mice.
- Recognition of a virus-encoded ligand by a natural killer cell activation receptor.
- In vivo developmental stages in murine natural killer cell maturation.
- Detailed phenotypic and molecular analyses of genetically modified mice generated by CRISPR-Cas9-mediated editing.
- Isolation of murine natural killer cells.
- Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells.
Schools
University of Hawaii At Manoa
University Iowa Hosps
Niaid Nih
Conditions Treated
- Fibromyalgia
- Systemic Lupus Erythematosus (SLE)
Doctors Specialties
- Rheumatology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Cigna HMO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Coventry Health Care of Illinois PPO
- MultiPlan PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Awards
- Elected Member
- Investigator Alumnus
- Investigator
- Fellow (FACR)
- Fellow
- Whos Who in Medicine and Healthcare
Education
-
National Institutes of Health Clinical Center -
University of Iowa Hospitals and Clinics -
University of Hawaii John A. Burns School of Medicine
Hospital
-
Barnes-Jewish Hospital
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