Chief, Renal-Electrolyte Division, Sheldon Adler Professor of Medicine
Nephrology
Dr. Thomas R. Kleyman, MD
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Thomas Kleyman practices Nephrology. He went to medical school at Washington University School of Medicine in St. Louis. He has 1 awards "Elected Member". Thomas Kleyman is a published doctor as well. He has 88 publications published. The latest was: An unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron.
Publications
- An unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron.
- Cutting it out: ENaC processing in the human nephron.
- Na+ inhibits the epithelial Na+ channel by binding to a site in an extracellular acidic cleft.
- Proteases, ENaCs and cystic fibrosis.
- Prostasin interacts With the epithelial Na+ channel and facilitates cleavage of the γ-subunit by a second protease.
- Effects of biomechanical forces on signaling in the cortical collecting duct (CCD).
- Deletion of α-subunit exon 11 of the epithelial Na+ channel reveals a regulatory module.
- Blood pressure and amiloride-sensitive sodium channels in vascular and Renal cells.
- Gamma subunit second transmembrane domain contributes to epithelial sodium channel gating and amiloride block.
- Regulation of large-conductance Ca2+-activated K+ channels by WNK4 kinase.
- ENaC regulation by proteases and shear stress.
- Gain-of-function variant of the human epithelial sodium channel.
- Role of the wrist domain in the response of the epithelial sodium channel to external stimuli.
- TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the gamma subunit distal to the furin cleavage site.
- Luminal flow modulates H+-ATPase activity in the cortical collecting duct (CCD).
- Role of NKCC in BK channel-mediated net K+ secretion in the CCD.
- Editor's Note: AJP-Cell and AJP-Renal honor the memory of Dale Benos With a series of articles.
- ENaC structure and function in the wake of a resolved structure of a family member.
- Second transmembrane domain modulates epithelial sodium channel gating in response to shear stress.
- Base of the thumb domain modulates epithelial sodium channel gating.
- Constraint-based, homology model of the extracellular domain of the epithelial Na+ channel α subunit reveals a mechanism of channel activation by proteases.
- The roles of mechanical forces in regulating tubular epithelial cell function and Renal vasculature. Editors' note.
- Allosteric inhibition of the epithelial Na+ channel through peptide binding at peripheral finger and thumb domains.
- Cys palmitoylation of the beta subunit modulates gating of the epithelial sodium channel.
- Role of epithelial sodium channels and their regulators in Hypertension.
- Defining an inhibitory domain in the gamma subunit of the epithelial sodium channel.
- Extracellular allosteric regulatory subdomain Within the gamma subunit of the epithelial Na+ channel.
- The endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones.
- Re: research in areas of transport physiology.
- Mechanoregulation of BK channel activity in the mammalian cortical collecting duct: role of protein kinases A and C.
- ENaC at the cutting edge: regulation of epithelial sodium channels by proteases.
- Novel determinants of epithelial sodium channel gating Within extracellular thumb domains.
- Plasmin and sodium retention in nephrotic syndrome.
- Plasmin activates epithelial Na+ channels by cleaving the gamma subunit.
- Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation.
- Effect of aldosterone on BK channel expression in mammalian cortical collecting duct.
- Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis.
- Defining an inhibitory domain in the alpha-subunit of the epithelial sodium channel.
- Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells.
- Epithelial sodium channel exit from the endoplasmic reticulum is regulated by a signal Within the carboxyl cytoplasmic domain of the alpha subunit.
- Functional cross talk between ENaC and pendrin.
- Small heat shock protein alphaA-crystallin regulates epithelial sodium channel expression.
- Intracellular trafficking of a polymorphism in the COOH terminus of the alpha-subunit of the human epithelial sodium channel is modulated by casein kinase 1.
- Functional role of extracellular loop cysteine residues of the epithelial Na+ channel in Na+ self-inhibition.
- Ca2+ dependence of flow-stimulated K secretion in the mammalian cortical collecting duct.
- Renal physiology: an evolving field.
- Lack of a role of membrane-protein interactions in flow-dependent activation of ENaC.
- Regulatory interactions of N1303K-CFTR and ENaC in Xenopus oocytes: evidence that chloride transport is not necessary for inhibition of ENaC.
- Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit.
- Salt, sodium channels, and SGK1.
- Regulation of cation transport in the distal nephron by mechanical forces.
- Distinct structural elements in the first membrane-spanning segment of the epithelial sodium channel.
- Airway surface liquid volume regulates ENaC by altering the serine protease-protease inhibitor balance: a mechanism for sodium hyperabsorption in cystic fibrosis.
- Mechanism underlying flow stimulation of sodium absorption in the mammalian collecting duct.
- The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its alpha subunit.
- Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.
- Clathrin-mediated endocytosis of the epithelial sodium channel. Role of epsin.
- Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels.
- Regulation of epithelial Na+ channels (ENaC) by methylation: a novel methyltransferase stimulates ENaC activity.
- Differential modulation of a polymorphism in the COOH terminus of the alpha-subunit of the human epithelial sodium channel by protein kinase Cdelta.
- Biophysical approach to determine the subunit stoichiometry of the epithelial sodium channel using the Xenopus laevis oocyte expression system.
- Dietary K+ regulates apical membrane expression of maxi-K channels in rabbit cortical collecting duct.
- On the interaction between amiloride and its putative alpha-subunit epithelial Na+ channel binding site.
- Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized Renal epithelial cells.
- Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels.
- Mutations in the pore region modify epithelial sodium channel gating by shear stress.
- Distinct pools of epithelial sodium channels are expressed at the plasma membrane.
- Mild nephrogenic Diabetes insipidus caused by Foxa1 deficiency.
- Ikappab kinase-beta (ikkbeta) modulation of epithelial sodium channel activity.
- Differential current decay profiles of epithelial sodium channel subunit combinations in polarized Renal epithelial cells.
- Extracellular Zn2+ activates epithelial Na+ channels by eliminating Na+ self-inhibition.
- Functional polymorphism in the carboxyl terminus of the alpha-subunit of the human epithelial sodium channel.
- Mutations in the extracellular loop of alpha-rENaC alter sensitivity to amiloride and reactive species.
- Cystic fibrosis transmembrane conductance regulator differentially regulates human and mouse epithelial sodium channels in Xenopus oocytes.
- Epithelial sodium channels are activated by furin-dependent proteolysis.
- Extracellular histidine residues crucial for Na+ self-inhibition of epithelial Na+ channels.
- Epithelial Na+ channels are activated by laminar shear stress.
- Characterization of an amiloride binding region in the alpha-subunit of ENaC.
- Hydrostatic pressure-regulated ion transport in bladder uroepithelium.
- Ontogeny of flow-stimulated potassium secretion in rabbit cortical collecting duct: functional and molecular aspects.
- Multiple epithelial Na+ channel domains participate in subunit assembly.
- Maturation of the epithelial Na+ channel involves proteolytic processing of the alpha- and gamma-subunits.
- Arachidonic acid regulates surface expression of epithelial sodium channels.
- Asymmetric organization of the pore region of the epithelial sodium channel.
- Genistein improves regulatory interactions between G551D-cystic fibrosis transmembrane conductance regulator and the epithelial sodium channel in Xenopus oocytes.
- External nickel inhibits epithelial sodium channel by binding to histidine residues Within the extracellular domains of alpha and gamma subunits and reducing channel o...
- Genistein restores functional interactions between Delta F508-CFTR and ENaC in Xenopus oocytes.
Schools
Washington Center School of Medicine
Procedures Preformed
- Hemodialysis
- Peritoneal Dialysis
Conditions Treated
- Acidosis
- Calcium Metabolism Disorders
- Chronic Kidney Diseases
- Diabetes With Renal Manifestations
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Doctors Specialties
- Nephrology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Blue Card PPO
- Great West Healthcare-Cigna PPO
- CoreSource
- HealthSmart
- Highmark Blue Cross Blue Shield
- Choice Care PPO
- Medicare MCR
- Medico
- MultiPlan PPO
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
- Universal American
- UPMC PPO
Awards
- Elected Member
Education
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New York Presbyterian Hospital - Columbia Campus -
Washington University School of Medicine in St. Louis
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1720055981 |
| Last Name Of The Provider | KLEYMAN |
| First Name Of The Provider | THOMAS |
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