Professor (Surgery, Immunology, and Medicine), University of Pittsburgh School of Medicine
Nephrology
Dr. Fadi G. Lakkis, MD
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Fadi Lakkis works in the field of Nephrology. He went to Wayne State University School of Medicine. Wayne State University School of Medicine is ranked 63/85 in Research/PrimaryCare. He has 1 awards "Elected Member". Fadi G. Lakkis is a published doctor as well. He has 100 publications published. The latest was: Breakdown of self-tolerance and the pathogenesis of autoimmunity. Fadi Lakkis is registered with Medicare.
Publications
- Dendritic cells and innate immunity in Kidney transplantation.
- Immunology: TREG cells in transplantation-a double-edged sword?
- Innate allorecognition.
- T-cell migration to vascularized organ allografts.
- Post-transplant repopulation of naïve and memory T cells in blood and lymphoid tissue after alemtuzumab-mediated depletion in Heart-transplanted cynomolgus monkeys.
- Molecular analysis of transplant rejection: marching onward.
- Cognate antigen directs CD8+ T cell migration to vascularized transplants.
- Allograft outcomes in outbred mice.
- Clinical islet xenotransplantation: how close are we?
- Evolutionary genetics of the hydroid allodeterminant alr2.
- Allorecognition triggers autophagy and subsequent necrosis in the cnidarian Hydractinia symbiolongicarpus.
- Early islet damage after direct exposure of pig islets to blood: has humoral immunity been underestimated?
- Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host Disease induction.
- Long-term effects of alemtuzumab on regulatory and memory T-cell subsets in Kidney transplantation.
- Genetic Background and Allorecognition Phenotype in Hydractinia symbiolongicarpus.
- Innate immunity alone is not sufficient for Chronic rejection but predisposes healed allografts to T cell-mediated pathology.
- T-lymphocyte homeostasis and function in infant baboons: implications for transplantation.
- Carbon monoxide inhibits apoptosis during cold storage and protects Kidney grafts donated after cardiac death.
- The innate immune system in transplantation.
- Memory T Cells Migrate to and Reject Vascularized Cardiac Allografts Independent of the Chemokine Receptor CXCR3.
- Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice.
- Genetic diversity of the allodeterminant alr2 in Hydractinia symbiolongicarpus.
- NK cells delay allograft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of CD8+ T cells.
- An innate response to allogeneic nonself mediated by monocytes.
- Allorecognition and chimerism in an invertebrate model organism.
- Langerhans cells are not required for efficient skin graft rejection.
- Ignorance is bliss.
- Differential effect of allorecognition loci on phenotype in Hydractinia symbiolongicarpus (Cnidaria: Hydrozoa).
- Induction of indoleamine 2,3-dioxygenase in vascular smooth muscle cells by interferon-gamma contributes to medial immunoprivilege.
- Declassifying glomerulonephritis.
- Embryonic chimerism does not induce tolerance in an invertebrate model organism.
- Effector T cell differentiation and memory T cell maintenance outside secondary lymphoid organs.
- The unfinished legacy of liver transplantation: emphasis on immunology.
- Testicular immune privilege promotes transplantation tolerance by altering the balance between memory and regulatory T cells.
- Impaired recall of CD8 memory T cells in immunologically privileged tissue.
- CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo.
- Transplantation tolerance: babies take the first step.
- Direct antigen presentation by a xenograft induces immunity independently of secondary lymphoid organs.
- The allograft defines the type of rejection (acute versus Chronic) in the face of an established effector immune response.
- CD4+CD25+ regulatory T cells suppress allograft rejection mediated by memory CD8+ T cells via a CD30-dependent mechanism.
- Technique for retransplanting heterotopic Heart grafts in mice.
- Memory T cells: a hurdle to immunologic tolerance.
- Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection.
- Cutting edge: perforin down-regulates CD4 and CD8 T cell-mediated immune responses to a transplanted organ.
- Transplant rejection: mind your T-cell language.
- Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs.
- Prospective Clinical Testing of Regulatory Dendritic Cells in Organ Transplantation.
- Memory T Cell Migration.
- Origin and biology of the allogeneic response.
- Cutting edge: Secondary lymphoid organs are essential for maintaining the CD4, but not CD8, naive T cell pool.
- Gene expression analysis in human Renal allograft biopsy samples using high-density oligoarray technology.
- Failure to induce neonatal tolerance in mice that lack both IL-4 and IL-13 but not in those that lack IL-4 alone.
- A scenic overlook on the road to clinical tolerance.
- FasL is important in costimulation blockade-resistant skin graft rejection.
- The dual role of IL-2 in the generation and maintenance of CD8+ memory T cells.
- Alloantigen-driven T cell death mediated by Fas ligand and tumor necrosis factor-alpha is not essential for the induction of allograft acceptance.
- Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue.
- The alloimmune response and effector mechanisms of allograft rejection.
- Interleukin-4 and interleukin-13 act on glomerular visceral epithelial cells.
- The role of cytokines, CTLA-4 and costimulation in transplant tolerance and rejection.
- The role of the common cytokine receptor gamma-chain in regulating IL-2-dependent, activation-induced CD8+ T cell death.
- Increased susceptibility to immunologically mediated glomerulonephritis in IFN-gamma-deficient mice.
- Regulation of alloantigen-mediated T-cell proliferation by endogenous interferon-gamma: implications for long-term allograft acceptance.
- Interferon-gamma is necessary for initiating the acute rejection of major histocompatibility complex class II-disparate skin allografts.
- Breakdown of self-tolerance and the pathogenesis of autoimmunity.
- Role of cytokines in transplantation tolerance: lessons learned from gene-knockout mice.
- Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient mice.
- T lymphocyte-derived cytokines in experimental glomerulonephritis: testing the Th1/Th2 hypothesis.
- IL-4 is an endogenous inhibitor of neutrophil influx and subsequent pathology in acute antibody-mediated inflammation.
- Differential regulation of expression of the MHC class II molecules RT1.B and RT1.D on rat B lymphocytes: effects of interleukin-4, interleukin-13 and interferon-gamma.
- IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways.
- Expression of recombinant rat interleukin-13 (IL-13) and generation of a neutralizing rat IL-13 antiserum.
- Immunologic determinants of susceptibility to experimental glomerulonephritis: role of cellular immunity.
- Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.
- Acute rejection of vascularized Heart allografts in the absence of IFNgamma.
- Anti-inflammatory lymphokine mRNA expression in antibody-induced glomerulonephritis.
- Encapsulated islet iso-, allo-, and xenografts in diabetic NOD mice.
- Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNAs in rat nephrotoxic nephritis.
- Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.
- Cloning of rat interleukin-13 (IL-13) cDNA and analysis of IL-13 gene expression in experimental glomerulonephritis.
- Lipoxygenase products in normal and Diseased glomeruli.
- Evidence for reciprocal regulation of pro- and anti-inflammatory lymphokines in rat nephrotoxic serum (NTS) nephritis.
- The role of cytokines in inflammatory glomerular injury.
- Requirements for primary T cell activation.
- Antibody valence and induced signal transduction: the role of antibody valence in anti-CD3-induced signal transduction in isolated normal T cells.
- Interleukin 4 receptor targeted cytotoxicity: genetic construction and in vivo immunosuppressive activity of a diphtheria toxin-related murine interleukin 4 fusion pro...
- Diphtheria toxin-related alpha-melanocyte-stimulating hormone fusion toxin. Internal in-frame deletion from Thr387 to His485 results in the formation of a highly poten...
- Protein engineering of diphtheria toxin. Development of receptor-specific cytotoxic agents for the treatment of human Disease.
- Phe496 and Leu497 are essential for receptor binding and cytotoxic action of the murine interleukin-4 receptor targeted fusion toxin DAB389-mIL-4.
- Sirolimus-based immunosuppression With reduce dose cyclosporine or tacrolimus after renal transplantation.
- Where is the alloimmune response initiated?
- In remembrance of things past: memory T cells and transplant rejection.
- Transplantation tolerance: a journey from ignorance to memory.
- Lymphoid neogenesis in murine cardiac allografts undergoing Chronic rejection.
- Tertiary lymphoid tissues generate effector and memory T cells that lead to allograft rejection.
- Acute cellular rejection with CD20-positive lymphoid clusters in Kidney transplant patients following lymphocyte depletion.
- Tolerance for organ recipients: a clash of paradigms.
- A hypervariable invertebrate allodeterminant.
- Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation.
Schools
American University Of Beirut Faculty Of Medicine
Wayne State University
Wayne St University Affil Hosps
Beth Israel Hospital Harvard Me
Conditions Treated
- Chronic Kidney Diseases
- Diabetes With Renal Manifestations
- End-Stage Renal Disease
- Hypertension
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Doctors Specialties
- Nephrology
Accepted Insurances
Awards
- Elected Member
Education
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Harvard Medical School -
Wayne State University School of Medicine -
American University of Beirut Faculty of Medicine
Hospital
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UPMC Presbyterian Shadyside
Drug Facts
| NPI NUMBER | 1417175910 | |
| NPPES Provider LastName | LAKKIS | |
| NPPES Provider FirstName | FADI | |
| NPPES Provider ZIPCode | 152610001 | |
| NPPES Provider State | PA | |
| Specialty Description | Nephrology | |
| Total Claim Count | 83.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1417175910 |
| Last Name Of The Provider | LAKKIS |
| First Name Of The Provider | FADI |
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