Professor, Dean's Office, University of California, San Francisco, School of Medicine

Pediatrics

Doctor Samuel Hawgood, MD practices Pediatrics. He attended The University of Queensland Medical School. He received awards:"Elected Member". Samuel Hawgood is a published doctor and has 101 publications published. The lastest was: 'Structure and properties of surfactant protein B.'

Publications

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• Innate immunity of surfactant proteins A and D in urinary tract infection with uropathogenic Escherichia coli.
• Mice Deficient in Surfactant Protein A (SP-A) and SP-D or in TLR2 Manifest Delayed Parturition and Decreased Expression of Inflammatory and Contractile Genes.
• Fetoscopic temporary tracheal occlusion by means of detachable balloon for congenital diaphragmatic hernia.
• Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity.
• Laser microdissection allows detection of abnormal gene expression in cystic adenomatoid malformation of the lung.
• Deletion of the transmembrane transporter ABCG1 results in progressive pulmonary lipidosis.
• Surfactant proteins A and D enhance pulmonary clearance of Pseudomonas aeruginosa.
• MR imaging of hepatic pulmonary fusion in neonates.
• Surfactant protein B: structure and function.
• GM-CSF mediates alveolar macrophage proliferation and type II cell hypertrophy in SP-D gene-targeted mice.
• Inhaled nitric oxide in neonates with persistent pulmonary hypertension.
• The pulmonary collectins and surfactant metabolism.
• Characterization of the mouse collectin gene locus.
• Ultrastructure of phospholipid mixtures reconstituted with surfactant proteins B and D.
• Localization of a candidate surfactant convertase to type II cells, macrophages, and surfactant subfractions.
• Structure and properties of surfactant protein B.
• Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D.
• Correction of congenital diaphragmatic hernia in utero IX: fetuses with poor prognosis (liver herniation and low lung-to-head ratio) can be saved by fetoscopic tempora...
• Identification of a novel alternatively spliced mRNA of murine pulmonary surfactant protein B.
• Identification of a putative surfactant convertase in rat lung as a secreted serine carboxylesterase.
• Surfactant protein genes and human disease: the plot thickens.
• Tracheal ligation increases cell proliferation but decreases surfactant protein in fetal murine lungs in vitro.
• Effects of mechanical factors on growth and maturation of the lung in fetal sheep.
• Lung function in premature rabbits treated with recombinant human surfactant protein-C.
• Localization and developmental expression of surfactant proteins D and A in the respiratory tract of the mouse.
• Kinetics of phospholipid membrane fusion induced by surfactant apoproteins A and B.
• Cell-specific posttranslational processing of the surfactant-associated protein SP-B.
• Lung surfactant proteins, SP-B and SP-C, alter the thermodynamic properties of phospholipid membranes: a differential calorimetry study.
• Amniotic fluid phospholipid analysis in the fetus with congenital diaphragmatic hernia.
• Association of surfactant protein C with isolated alveolar type II cells.
• Lung function, surfactant apoprotein content, and level of PEEP in prematurely delivered rabbits.
• Surfactant apoprotein A modifies the inhibitory effect of plasma proteins on surfactant activity in vivo.
• Functions of the surfactant proteins: a perspective.
• Hospital referrals of home births in the intrapartum and postpartum periods.
• Simple and rapid high-performance liquid chromatographic method for the quantification of 3-methylhistidine.
• Intraventricular hemorrhage. Incidence and outcome in a population of very-low-birth-weight infants.
• Computerised nutritional data management in neonatal intensive care.
• An electrophoretic and immunochemical characterization of human surfactant-associated proteins.
• Role of apoprotein and calcium ions in surfactant function.
• Effects of a surfactant-associated protein and calcium ions on the structure and surface activity of lung surfactant lipids.
• Structure of canine pulmonary surfactant apoprotein: cDNA and complete amino acid sequence.
• Structural and functional aspects of protein: phospholipid interactions in surfactant.
• Surfactant apoprotein Mr = 26,000-36,000 enhances uptake of liposomes by type II cells.
• Sialic acid of lung surfactant apoprotein, SP 28-36, is not required for the Ca2+-mediated interactions between surfactant lipids and SP 28-36.
• Low molecular weight human pulmonary surfactant protein (SP5): isolation, characterization, and cDNA and amino acid sequences.
• Pulmonary surfactant and its components inhibit secretion of phosphatidylcholine from cultured rat alveolar type II cells.
• Nucleotide and amino acid sequences of pulmonary surfactant protein SP 18 and evidence for cooperation between SP 18 and SP 28-36 in surfactant lipid adsorption.
• Regulation of pulmonary surfactant apoprotein SP 28-36 gene in fetal human lung.
• Divalent cation and hydrogen ion effects on the structure and surface activity of pulmonary surfactant.
• Interactions of the low molecular weight group of surfactant-associated proteins (SP 5-18) with pulmonary surfactant lipids.
• Synthesis of surfactant components by cultured type II cells from human lung.
• Surfactant protein of molecular weight 28,000-36,000 in cultured human fetal lung: cellular localization and effect of dexamethasone.
• Monoclonal antibodies to surfactant proteins SP28-36 label canine type II and nonciliated bronchiolar cells by immunofluorescence.
• The role of calcium in the secretion of surfactant by rat alveolar type II cells.
• Chemical characterization of lung surfactant apoproteins: amino acid composition, N-terminal sequence and enzymic digestion.
• Isolation and characterization of the human pulmonary surfactant apoprotein gene.
• The major lung surfactant protein, SP 28-36, is a calcium-dependent, carbohydrate-binding protein.
• Proteolytic inactivation of dog lung surfactant-associated proteins by neutrophil elastase.
• Pulmonary surfactant apoproteins: a review of protein and genomic structure.
• Pulmonary surfactant metabolism.
• Studies of the structure of lung surfactant protein SP-A.
• Regulation of messenger RNAs for the hydrophobic surfactant proteins in human lung.
• Lung surfactant apoprotein SP-A (26-36 kDa) binds with high affinity to isolated alveolar type II cells.
• Binding of calcium to SP-A, a surfactant-associated protein.
• Pulmonary surfactant and its apoproteins.
• Structures and properties of the surfactant-associated proteins.
• Changes in lipid structure produced by surfactant proteins SP-A, SP-B, and SP-C.
• Effects of surfactant apolipoproteins on liposome structure: implications for tubular myelin formation.
• Surfactant protein A (SP-A) is decreased in acute parenchymal lung injury associated with polytrauma.
• Specific binding of surfactant apoprotein SP-A to rat alveolar macrophages.
• Vegan mothers with vitamin B12 deficiency.
• Bee-sting anaphylaxis in childhood.
• Surfactant proteins in pulmonary alveolar proteinosis in adults.
• The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia.
• Surfactant protein D deficiency influences allergic immune responses.
• Early variable-flow nasal continuous positive airway pressure in infants < or =1000 grams at birth.
• Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice.
• Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis.
• Clearance of Pseudomonas aeruginosa from a healthy ocular surface involves surfactant protein D and is compromised by bacterial elastase in a murine null-infection model.
• A recombinant fragment of human surfactant protein D lacking the short collagen-like stalk fails to correct morphological alterations in lungs of SP-D deficient mice.
• Simultaneous absence of surfactant proteins A and D increases lung inflammation and injury after allogeneic HSCT in mice.
• Expression of surfactant protein D in human corneal epithelial cells is upregulated by Pseudomonas aeruginosa.
• Genetic analysis of congenital cystic adenomatoid malformation reveals a novel pulmonary gene: fatty acid binding protein-7 (brain type).
• Truncated recombinant human SP-D attenuates emphysema and type II cell changes in SP-D deficient mice.
• Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1.
• N-linked glycosylation attenuates H3N2 influenza viruses.
• Helicobacter infection in the surfactant protein D-deficient mouse.
• Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice.
• Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy.
• IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response.
• Surfactant protein D is proatherogenic in mice.
• Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrog...
• Mast cells protect mice from Mycoplasma pneumonia.
• Design-based stereological analysis of the lung parenchymal architecture and alveolar type II cells in surfactant protein A and D double deficient mice.
• Alveolar surfactant protein D content modulates bleomycin-induced lung injury.
• Innate immune collectin surfactant protein D enhances the clearance of DNA by macrophages and minimizes anti-DNA antibody generation.
• Surfactant protein D is present in human tear fluid and the cornea and inhibits epithelial cell invasion by Pseudomonas aeruginosa.
• Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung.
• Surfactant protein B in type II pneumocytes and intra-alveolar surfactant forms of human lungs.
• Surfactant protein-D, a mediator of innate lung immunity, alters the products of nitric oxide metabolism.

Doctors Specialties

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• Pediatrics

Accepted Insurances

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Awards

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• Elected Member

Education

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• The University of Queensland Medical School

Hospital

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• San Francisco General Hospital and Trauma Center
• UCSF Medical Center

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