Professor of Medicine, Dana-Farber Cancer Institute
Oncology
Dr. Ruth M. Ruprecht, MD
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Dr. Ruth M. Ruprecht is an expert in the field of Oncology. She graduated from University of Miami Miller School of Medicine. University of Miami Miller School of Medicine has a rank of 45 in research and a 0 in primary care Ruth Ruprecht is also published. She has 100 publications published. The lastest publication: "Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques.'
Publications
- Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: Complete protection of rhesus monkeys from mucosal SHIV challenge.
- Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus.
- Multimodality vaccination against clade C SHIV: Partial protection against mucosal challenges with a heterologous tier 2 virus.
- The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells.
- Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission.
- Impact of antibody quality and anamnestic response on viremia control post-challenge in a combined Tat/Env vaccine regimen in rhesus macaques.
- Novel Biopanning Strategy: A Tool to Identify Epitopes Associated with Vaccine Protection.
- Isolation of monoclonal antibodies with predetermined conformational epitope specificity.
- No Acquisition: a New Ambition for HIV Vaccine Development?
- Neutralization Efficiency of Neutralizing Antibodies Targeting the CD4-Binding Site: Influence of Conformational Masking by the V2 Loop in R5-Tropic Clade C SHIV.
- Molecularly cloned SHIV-CN97001: a replication-competent, R5???simian/human immunodeficiency virus containing env of a primary Chinese HIV-1 clade C isolate.
- Schistosoma mansoni Enhances Host Susceptibility to Mucosal but Not Intravenous Challenge by R5 Clade C SHIV.
- Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: Efficacy against repeated mucosal R5 clade C SHIV challenges.
- Vaccination against Heterologous R5 Clade C SHIV: Prevention of Infection and Correlates of Protection.
- R5-SHIV Induces Multiple Defects in T Cell Function during Early Infection of Rhesus Macaques Including Accumulation of T Reg Cells in Lymph Nodes.
- An Anti-HIV-1 V3 Loop Antibody Fully Protects Cross-Clade and Elicits T-Cell Immunity in Macaques Mucosally Challenged with an R5 Clade C SHIV.
- Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transm...
- R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models.
- CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids.
- Generation of recombinant vaccinia viruses via green fluorescent protein selection.
- Neutralization-sensitive R5-tropic simian-human immunodeficiency virus SHIV-2873Nip, which carries env isolated from an infant with a recent HIV clade C infection.
- Passive immunization with human neutralizing monoclonal antibodies against HIV-1 in macaque models: experimental approaches.
- Cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody that recognizes a novel conformational epitope on gp41 and lacks reactivity a...
- Recent advances in the characterization of HIV-1 neutralization assays for standardized evaluation of the antibody response to infection and vaccination.
- Acute Schistosoma mansoni infection increases susceptibility to systemic SHIV clade C infection in rhesus macaques after mucosal virus exposure.
- Inducing cross-clade neutralizing antibodies against HIV-1 by immunofocusing.
- Coinfection with Schistosoma mansoni reactivates viremia in rhesus macaques with chronic simian-human immunodeficiency virus clade C infection.
- Time dependence of protective post-exposure prophylaxis with human monoclonal antibodies against pathogenic SHIV challenge in newborn macaques.
- Dendritic cell-based vaccine strategy against human immunodeficiency virus clade C: skewing the immune response toward a helper T cell type 2 profile.
- Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques.
- Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus m...
- Dichotomy in cross-clade reactivity and neutralization by HIV-1 sera: Implications for active and passive immunotherapy.
- Phosphorylation of HIV Nef by cAMP-dependent protein kinase.
- Long-term productive human immunodeficiency virus infection of CD1a-sorted myeloid dendritic cells.
- Older rhesus macaque infants are more susceptible to oral infection with simian-human immunodeficiency virus 89.6P than neonates.
- Infectious molecular clone of a recently transmitted pediatric human immunodeficiency virus clade C isolate from Africa: evidence of intraclade recombination.
- Synthesis and assembly of SIVmac Gag p27 capsid protein cholera toxin B subunit fusion protein in transgenic potato.
- Complete protection of neonatal rhesus macaques against oral exposure to pathogenic simian-human immunodeficiency virus by human anti-HIV monoclonal antibodies.
- Live attenuated HIV vaccines: pitfalls and prospects.
- Potent cross-group neutralization of primary human immunodeficiency virus isolates with monoclonal antibodies--implications for acquired immunodeficiency syndrome vacc...
- Convergent evolution of SIV env after independent inoculation of rhesus macaques with infectious proviral DNA.
- Primary African HIV clade A and D isolates: effective cross-clade neutralization with a quadruple combination of human monoclonal antibodies raised against clade B.
- RNA interference--a new weapon against HIV and beyond.
- Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time reverse transcriptase-polymerase chain reaction: variations in expression during chronic prim...
- Molecular evolution of human immunodeficiency virus env in humans and monkeys: similar patterns occur during natural disease progression or rapid virus passage.
- Rev-independent simian immunodeficiency virus strains are nonpathogenic in neonatal macaques.
- Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose.
- Live attenuated rev-independent Nef¯SIV enhances acquisition of heterologous SIVsmE660 in acutely vaccinated rhesus macaques.
- Variations in the Biological Functions of HIV-1 Clade C Envelope in a SHIV-Infected Rhesus Macaque during Disease Progression.
- Protection of neonatal macaques against experimental SHIV infection by human neutralizing monoclonal antibodies.
- Extensively deleted simian immunodeficiency virus (SIV) DNA in macaques inoculated with supercoiled plasmid DNA encoding full-length SIVmac239.
- Passive immunization against oral AIDS virus transmission: an approach to prevent mother-to-infant HIV-1 transmission?
- Antibodies and HIV: new evidence. Interview with Ruth Ruprecht, M.D., Ph.D. Interview by David Scondras and John S. James.
- Postnatal passive immunization of neonatal macaques with a triple combination of human monoclonal antibodies against oral simian-human immunodeficiency virus challenge.
- Potent neutralization of primary human immunodeficiency virus clade C isolates with a synergistic combination of human monoclonal antibodies raised against clade B.
- Synergy, activity and tolerability of zidovudine and interferon-alpha in patients with symptomatic HIV-1 infection: AIDS Clincal Trial Group 068.
- Sensitive and robust one-tube real-time reverse transcriptase-polymerase chain reaction to quantify SIV RNA load: comparison of one- versus two-enzyme systems.
- 1999: a time to re-evaluate AIDS vaccine strategies.
- Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection.
- Live attenuated AIDS viruses as vaccines: promise or peril?
- Persistent infection of rhesus macaques by the rev-independent Nef(-) simian immunodeficiency virus SIVmac239: replication kinetics and genomic stability.
- Vaccine protection by subinfectious doses of a live murine leukemia virus.
- Viremia and AIDS in rhesus macaques after intramuscular inoculation of plasmid DNA encoding full-length SIVmac239.
- Oral transmission of primate lentiviruses.
- Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques.
- Isolation of high-molecular-weight genomic DNA from intact biohazardous mammalian tissues.
- Inhibition of HIV-1 replication by an aqueous extract of Spirulina platensis (Arthrospira platensis).
- Oral SIV, SHIV, and HIV type 1 infection.
- Synergistic neutralization of simian-human immunodeficiency virus SHIV-vpu+ by triple and quadruple combinations of human monoclonal antibodies and high-titer anti-hum...
- Phylogenetic relationship of the complete Rauscher murine leukemia virus genome with other murine leukemia virus genomes.
- Detection of simian T cell leukemia virus type I infection in seronegative macaques.
- SIV/DeltaB670 transmission across oral, colonic, and vaginal mucosae in the macaque.
- Human immunodeficiency virus-1 entry into purified blood dendritic cells through CC and CXC chemokine coreceptors.
- Synergistic neutralization of a chimeric SIV/HIV type 1 virus with combinations of human anti-HIV type 1 envelope monoclonal antibodies or hyperimmune globulins.
- Simultaneous detection of simian retrovirus type D serotypes 1, 2, and 3 by polymerase chain reaction.
- Neutralizing and infection-enhancing antibody responses do not correlate with the differential pathogenicity of SIVmac239delta3 in adult and infant rhesus monkeys.
- Murine and simian retrovirus models: the threshold hypothesis.
- "Attenuated" simian immunodeficiency virus in macaque neonates.
- Correlates of immune protection after vaccination with attenuated live murine leukemia virus.
- Infection and AIDS in adult macaques after nontraumatic oral exposure to cell-free SIV.
- Attenuated HIV vaccine: caveats.
- Simian immunodeficiency virus infection via amniotic fluid: a model to study fetal immunopathogenesis and prophylaxis.
- Chemoprevention of retroviral infection: success is determined by virus inoculum strength and cellular immunity.
- Animal models for perinatal transmission of pathogenic viruses.
- Negative regulation of the 5' long terminal repeat (LTR) by the 3' LTR in the murine proviral genome.
- Mucosal infection of neonatal rhesus monkeys with cell-free SIV.
- Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques.
- Attenuated vaccines for AIDS?
- Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes.
- Acutely infected Langerhans cells are more efficient than T cells in disseminating HIV type 1 to activated T cells following a short cell-cell contact.
- The Cronkhite-Canada Syndrome. An analysis of clinical and pathologic features and therapy in 55 patients.
- Gene transfer in intact animals.
- The presence of unique DNA sequences after viral induction of leukemia in mice. (RNA tumor virus-nucleic acid hybridization-insertion of viral DNA).
- Determination of natural host taxonomy of RNA tumor viruses by molecular hybridization: application to RD-114, a candidate human virus.
- Viral-related DNA sequences before and after transformation by RNA tumor viruses.
- Conditions for the selective synthesis of DNA complementary to template RNA.
- Alkylating agent resistance: in vitro studies with human cell lines.
- Analysis of suramin plasma levels by ion-pair high-performance liquid chromatography under isocratic conditions.
- Suppression of mouse viraemia and retroviral disease by 3''-azido-3''-deoxythymidine.
Schools
University of Miami School of Medicine
University Of California Los Angeles
Meml Sloan Kettering Center
Doctors Specialties
- Medical Oncology
- Oncology
Accepted Insurances
Education
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Memorial Sloan-Kettering Cancer Center -
UCLA Medical Center -
University of Miami Miller School of Medicine
Hospital
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Dana-Farber Cancer Institute
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