Assistant Professor of Medicine, Dana-Farber Cancer Institute
Oncology
Dr. Matthew L. Freedman, MD
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Doctor Matthew L. Freedman, MD practices Oncology. He went to University of Michigan Medical School. He over the years received 1 awards: "Elected Member". Matthew Freedman is a published MD as well. He has 66 publications published. The latest was: Exome sequencing reveals recurrent germline variants in patients with familial Waldenstrom's macroglobulinemia.
Publications
- CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants.
- Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer.
- The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis.
- Validation and genomic interrogation of the MET variant rs11762213 as a predictor of adverse outcomes in clear cell renal cell carcinoma.
- Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases.
- Cell Type Specific Enrichment Of Risk Associated Regulatory Elements At Ovarian Cancer Susceptibility Loci.
- Association of prostate cancer risk variants with gene expression in normal and tumor tissue.
- A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
- Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types.
- Aspirin Use, 8q24 Single Nucleotide Polymorphism rs6983267, and Colorectal Cancer According to CTNNB1 Alterations.
- Lessons from postgenome-wide association studies: functional analysis of cancer predisposition loci.
- Macrocytic Anemia and Mitochondriopathy Resulting from a Defect in Sideroflexin 4.
- Clinical uncertainty of prostate cancer genetic risk panels.
- Snx3 Regulates Recycling of the Transferrin Receptor and Iron Assimilation.
- Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci.
- Single nucleotide polymorphisms and risk of recurrence of renal-cell carcinoma: a cohort study.
- Calling amplified haplotypes in next generation tumor sequence data.
- The genetics of cancer risk.
- The Impact of Common Genetic Variations in Genes of the Sex Hormone Metabolic Pathways on Steroid Hormone Levels and Prostate Cancer Aggressiveness.
- Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth.
- mRNA expression signature of Gleason grade predicts lethal prostate cancer.
- Principles for the post-GWAS functional characterization of cancer risk loci.
- National Cancer Institute Prostate Cancer Genetics Workshop.
- Association of prostate cancer risk Loci with disease aggressiveness and prostate cancer-specific mortality.
- Inherited variants in the chemokine CCL2 gene and prostate cancer aggressiveness in a Caucasian cohort.
- Single-nucleotide polymorphisms in p53 pathway and aggressiveness of prostate cancer in a Caucasian population.
- Genome-wide association study of prostate cancer mortality.
- Analysis of the 10q11 cancer risk locus implicates MSMB and NCOA4 in human prostate tumorigenesis.
- Genetics of prostate cancer risk.
- A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer risk. Results from the National Cancer Institute Brea...
- Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival.
- Allelic selection of amplicons in glioblastoma revealed by combining somatic and germline analysis.
- Inherited variations in AR, ESR1, and ESR2 genes are not associated with prostate cancer aggressiveness or with efficacy of androgen deprivation therapy.
- Chromosome 8q24-Associated Cancers and MYC.
- 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC.
- A systematic approach to understand the functional consequences of non-protein coding risk regions.
- An admixture scan in 1,484 African American women with breast cancer.
- Replication of prostate cancer risk loci in a Japanese case-control association study.
- Prevalence and functional analysis of sequence variants in the ATR checkpoint mediator Claspin.
- Prostate cancer cognitive-behavioral factors in a West African population.
- The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.
- Evaluation of the 8q24 prostate cancer risk locus and MYC expression.
- Evaluation of 8q24 and 17q risk loci and prostate cancer mortality.
- Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X.
- Circulating colony stimulating factor-1 and breast cancer risk.
- Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts.
- Genetic determinants of circulating insulin-like growth factor (IGF)-I, IGF binding protein (BP)-1, and IGFBP-3 levels in a multiethnic population.
- Multiple regions within 8q24 independently affect risk for prostate cancer.
- A common 8q24 variant in prostate and breast cancer from a large nested case-control study.
- Transferability of tag SNPs in genetic association studies in multiple populations.
- Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohort.
- Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men.
- Common genetic variation at PTEN and risk of sporadic breast and prostate cancer.
- Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studies.
- Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort.
- Igf-I genetic variation and breast cancer: the multiethnic cohort.
- Genetic variation in the HSD17B1 gene and risk of prostate cancer.
- A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk.
- Demonstrating stratification in a European American population.
- Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort.
- Systematic evaluation of genetic variation at the androgen receptor locus and risk of prostate cancer in a multiethnic cohort study.
- Assessing the impact of population stratification on genetic association studies.
- Deconvoluting complex tissues for expression quantitative trait locus-based analyses.
- Exome sequencing reveals recurrent germline variants in patients with familial Waldenstrom's macroglobulinemia.
- A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men.
Schools
University of Mi Med Sch
Brigham and Women39s Hospital
Doctors Specialties
- Medical Oncology
- Oncology
Accepted Insurances
Awards
- Elected Member
Education
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Brigham and Women's Hospital -
University of Pennsylvania Health System -
University of Michigan Medical School
Hospital
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Dana-Farber Cancer Institute
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