James L. Gamble Professor of Pediatrics, Boston Children's Hospital
Allergy & Immunology
Dr. Raif S. Geha, MD
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Doctor Raif S. Geha, MD works in the field of Allergy & Immunology. He over the years received 1 awards: "Elected Member". Raif Geha is a published MD. He has 100 papers published. The most current publication "O-008 Aberrant Anti-inflammatory Macrophage Function and Differentiation in Wiskott-Aldrich Syndrome Protein-Deficient Mice and Humans."
Publications
- O-008 Aberrant Anti-inflammatory Macrophage Function and Differentiation in Wiskott-Aldrich Syndrome Protein-Deficient Mice and Humans.
- Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in IκBα.
- The microbiota is important for IL-17A expression and neutrophil infiltration in lesional skin of Flg(ft/ft) mice.
- Binding of WIP to Actin is Essential for T Cell Actin Cytoskeleton Integrity and Tissue Homing.
- A novel mutation in FOXN1 resulting in SCID: A case report and literature review.
- CCL25/CCR9 Interactions Are Not Essential for Colitis Development but Are Required for Innate Immune Cell Protection from Chronic Experimental Murine Colitis.
- Binding of the WASP/N-WASP interacting protein WIP to actin regulates focal adhesion assembly and adhesion.
- TRIF Signaling Is Essential for TLR4-Driven IgE Class Switching.
- Flow cytometry biomarkers distinguish DOCK8 deficiency from severe atopic dermatitis.
- A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency.
- Wiskott-Aldrich syndrome: a comprehensive review.
- Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency.
- Use of whole exome and genome sequencing in the identification of genetic causes of primary immunodeficiencies.
- Leukotriene b4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation.
- EPEC and vaccinia virus do not require WIP family proteins for pathogen-induced actin assembly.
- A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP.
- Vaccinia Ig Ameliorates Eczema Vaccinatum in a Murine Model of Atopic Dermatitis.
- Immunization with modified vaccinia virus Ankara prevents eczema vaccinatum in a murine model of atopic dermatitis.
- Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation.
- Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin.
- A peptide derived from the Wiskott-Aldrich syndrome (WAS) protein-interacting protein (WIP) restores WAS protein level and actin cytoskeleton reorganization in lymphoc...
- Functional analysis of transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) mutations associated with common variable immunodeficiency.
- The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency.
- Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis...
- Mechanical injury polarizes skin dendritic cells to elicit a T(H)2 response by inducing cutaneous thymic stromal lymphopoietin expression.
- Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency.
- The prostaglandin Dâ‚‚ receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge.
- Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking.
- Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients.
- Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene.
- Thymic stromal lymphopoietin.
- Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP.
- Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.
- The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function.
- Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response.
- Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen.
- Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells.
- Reply to Narra.
- WIP is critical for T cell responsiveness to IL-2.
- Toll-like receptor 2 is important for the T(H)1 response to cutaneous sensitization.
- IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice.
- Cellular and molecular mechanisms in atopic dermatitis.
- Animal models of atopic dermatitis.
- Primary immune deficiencies with aberrant IgE production.
- Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficie...
- Transmembrane activator and calcium-modulator and cyclophilin ligand interactor mutations in common variable immunodeficiency.
- A girl with severe hand swelling and abdominal cramps.
- TSLP acts on infiltrating effector T cells to drive allergic skin inflammation.
- Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL.
- Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.
- B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE.
- Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation.
- Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge.
- Heterozygous N-terminal deletion of IkappaBalpha results in functional nuclear factor kappaB haploinsufficiency, ectodermal dysplasia, and immune deficiency.
- Transmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiation.
- Images in immunodeficiency.
- Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID).
- Transcellular diapedesis is initiated by invasive podosomes.
- WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).
- TACI, isotype switching, CVID and IgAD.
- CD1d restricted natural killer T cells are not required for allergic skin inflammation.
- Interleukin receptor-associated kinase-4 deficiency impairs Toll-like receptor-dependent innate antiviral immune responses.
- TACI mutation in common variable immunodeficiency and IgA deficiency.
- 3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation.
- The H1 histamine receptor regulates allergic lung responses.
- The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen.
- IPEX and the role of Foxp3 in the development and function of human Tregs.
- A second-site mutation in the initiation codon of WAS (WASP) results in expansion of subsets of lymphocytes in an Wiskott-Aldrich syndrome patient.
- Molecular basis of common variable immunodeficiency.
- 2. Update on primary immunodeficiency diseases.
- A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.
- Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Al...
- Charles A. Janeway and Fred S. Rosen: the discovery of gamma globulin therapy and primary immunodeficiency diseases at Boston Children's Hospital.
- TACI is mutant in common variable immunodeficiency and IgA deficiency.
- COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization.
- Are you immunodeficient?
- Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane.
- Jun N-terminal kinase is essential for CD40-mediated IgE class switching in B cells.
- Role of APRIL in the mucosal Iga antibody response.
- TACI and BAFF-R mediate isotype switching in B cells.
- Characteristics of mycobacterial infection in patients with immunodeficiency and nuclear factor-kappaB essential modulator mutation, with or without ectodermal dysplasia.
- Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia.
- RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation.
- The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen.
- Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP.
- The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation.
- Impaired IgA class switching in APRIL-deficient mice.
- WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells.
- The mature activating natural killer cell immunologic synapse is formed in distinct stages.
- Epicutaneous sensitization with superantigen induces allergic skin inflammation.
- Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation.
- Finding NEMO: genetic disorders of NF-[kappa]B activation.
- IL-10 is critical for Th2 responses in a murine model of allergic dermatitis.
- Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells.
- Acute chylothorax in children: selective retention of memory T cells and natural killer cells.
- C4b-binding protein (C4BP) activates B cells through the CD40 receptor.
- Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells.
- IgG Fc receptor polymorphisms in human disease: implications for intravenous immunoglobulin therapy.
- 12. Primary immunodeficiency diseases.
Schools
American University of Beirut Faculty of Medicine
American University Hospital
Childrens Hospital Med Center
Conditions Treated
- Hypogammaglobulinemia
Doctors Specialties
- Allergy
- Immunology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Blue Card PPO
- BlueConnect HMO
- Blue with Managed Care Behavioral Health HMO
- Preferred Blue PPO
- GHI PPO
- First Health (Coventry Health Care) PPO
- Choice Care PPO
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Tufts PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Awards
- Elected Member
Education
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Boston Children's Hospital -
American University of Beirut Faculty of Medicine
Hospital
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Boston Children's Hospital
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