Professor, Pediatrics, Perelman School of Medicine
Pediatric Infectious Disease
Dr. Paul A. Offit, MD
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Dr. Paul A. Offit is an expert in the field of Pediatric Infectious Disease. He researched medicine at University of Maryland School of Medicine. University of Maryland School of Medicine has a rank of 37 in research and a 52 in primary care He received awards:"Elected Member", "Super Doctor", "Whos Who in Medicine and Healthcare" and "Top MD". Paul A. Offit is a published physician as well. He has 100 publications published. The latest was: Rotavirus-specific proteins are detected in murine macrophages in both intestinal and extraintestinal lymphoid tissues.
Publications
- Communicating vaccine science to the public.
- Vaccines and autism revisited--the Hannah Poling case.
- Delaying vaccination is not a safer choice.
- Thimerosal and vaccines--a cautionary tale.
- Thimerosal and autism.
- Preventing harm from thimerosal in vaccines.
- Should childhood vaccination be mandatory? Yes.
- Influence of potential protective mechanisms on the development of live rotavirus vaccines.
- Vaccines and autism: a tale of shifting hypotheses.
- The problem with Dr Bob's alternative vaccine schedule.
- New book about vaccine safety.
- The new pentavalent rotavirus vaccine composed of bovine (strain WC3) -human rotavirus reassortants.
- Rotavirus vaccines: round two.
- RotaTeq: a pentavalent bovine--human reassortant rotavirus vaccine.
- Why are pharmaceutical companies gradually abandoning vaccines?
- The Cutter incident, 50 years later.
- Vaccines for rotavirus gastroenteritis universally needed for infants.
- Rotavirus immunoglobulin a responses stimulated by each of 3 doses of a quadrivalent human/bovine reassortant rotavirus vaccine.
- Infant immune response to human rotavirus serotype G1 vaccine candidate reassortant WI79-9: different dose response patterns to virus surface proteins VP7 and VP4.
- The meningococcal vaccine--public policy and individual choices.
- Addressing parents' concerns: do vaccines contain harmful preservatives, adjuvants, additives, or residuals?
- Addressing parents' concerns: do vaccines cause allergic or autoimmune diseases?
- Yellow fever vaccine. Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2002.
- The future of rotavirus vaccines.
- Addressing parents' concerns: do multiple vaccines overwhelm or weaken the infant's immune system?
- Employee designation and health care worker support of an influenza vaccine mandate at a large pediatric tertiary care hospital.
- Effects of the potency and composition of the multivalent human-bovine (WC3) reassortant rotavirus vaccine on efficacy, safety and immunogenicity in healthy infants.
- Back to the future.
- Meningococcal conjugate vaccine in the UK: an update.
- Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine.
- Development of a pentavalent rotavirus vaccine against prevalent serotypes of rotavirus gastroenteritis.
- Communicating science to the public: MMR vaccine and autism.
- Safety, immunogenicity and efficacy in healthy infants of G1 and G2 human reassortant rotavirus vaccine in a new stabilizer/buffer liquid formulation.
- The power of ''box a''.
- Determination of efficiency of attachment of biotinylated antibodies to avidin-linked, aqueous-based microcapsules by flow cytometry.
- Safety, efficacy, and immunogenicity of a live, quadrivalent human-bovine reassortant rotavirus vaccine in healthy infants.
- Distribution of rotavirus-specific memory B cells in gut-associated lymphoid tissue after primary immunization.
- How vaccine safety is monitored before and after licensure.
- Correlates of protection against rotavirus infection and disease.
- B2 but not B1 cells can contribute to CD4+ T-cell-mediated clearance of rotavirus in SCID mice.
- Hypertrophy, hyperplasia, and infectious virus in gut-associated lymphoid tissue of mice after oral inoculation with simian-human or bovine-human reassortant rotaviruses.
- Maintaining the public's trust in immunizations.
- Circulating rotavirus-specific antibody-secreting cells (ASCs) predict the presence of rotavirus-specific ASCs in the human small intestinal lamina propria.
- Primary murine small intestinal epithelial cells, maintained in long-term culture, are susceptible to rotavirus infection.
- A quantitative luminescence assay for measuring cell uptake of aqueous-based microcapsules in vitro.
- Migration of antigen-presenting B cells from peripheral to mucosal lymphoid tissues may induce intestinal antigen-specific IgA following parenteral immunization.
- The rotavirus vaccine.
- Rotavirus-specific proteins are detected in murine macrophages in both intestinal and extraintestinal lymphoid tissues.
- Effect of water-based microencapsulation on protection against EDIM rotavirus challenge in mice.
- New vaccines against mucosal pathogens: rotavirus and respiratory syncytial virus.
- Induction of mucosal B-cell memory by intramuscular inoculation of mice with rotavirus.
- Relative importance of rotavirus-specific effector and memory B cells in protection against challenge.
- Effect of microencapsulation on immunogenicity of a bovine herpes virus glycoprotein and inactivated influenza virus in mice.
- Immunologic correlates of protection against rotavirus challenge after intramuscular immunization of mice.
- WC3 reassortant vaccines in children.
- Aqueous-based microencapsulation enhances virus-specific humoral immune responses in mice after parenteral inoculation.
- The development of multivalent bovine rotavirus (strain WC3) reassortant vaccine for infants.
- Host factors associated with protection against rotavirus disease: the skies are clearing.
- Rotavirus-specific intestinal immune response in mice assessed by enzyme-linked immunospot assay and intestinal fragment culture.
- Rotavirus-specific humoral and cellular immune response after primary, symptomatic infection.
- Induction of rotavirus-specific cytotoxic T lymphocytes by vaccinia virus recombinants expressing individual rotavirus genes.
- Evaluation of a bovine-human rotavirus reassortant vaccine in infants.
- VP4 genotyping of human rotavirus in the United States.
- Rotavirus pathology and pathophysiology.
- Immunologic determinants of protection against rotavirus disease.
- Enhancement of rotavirus immunogenicity by microencapsulation.
- Rotaviruses: immunological determinants of protection against infection and disease.
- Enhancement by microencapsulation of rotavirus-specific intestinal immune responses in mice assessed by enzyme-linked immunospot assay and intestinal fragment culture.
- Induction of virus-specific antibody production by lamina propria lymphocytes following intramuscular inoculation with rotavirus.
- Oral inoculation of mice with low doses of microencapsulated, noninfectious rotavirus induces virus-specific antibodies in gut-associated lymphoid tissue.
- Evaluation of the protective efficacy of a serotype 1 bovine-human rotavirus reassortant vaccine in infants.
- Acyclovir therapy in neonatal herpes simplex virus infection.
- Ampicillin-resistant, beta-lactamase-negative haemophilus influenzae type b.
- A murine model for oral infection with a primate rotavirus (simian SA11).
- The cultivation of human rotavirus, strain ''Wa'', to high titer in cell culture and characterization of the viral structural polypeptides.
- Response of mice to rotaviruses of bovine or primate origin assessed by radioimmunoassay, radioimmunoprecipitation, and plaque reduction neutralization.
- Viral diseases: infections of the gastrointestinal tract.
- Severe Epstein-Barr virus pulmonary involvement.
- Rotavirus-specific antibodies in fetal bovine serum and commercial preparations of serum albumin.
- Gastroenteritis caused by human rotaviruses (serotype three) in a suckling mouse model.
- Reassortant rotaviruses containing structural proteins vp3 and vp7 from different parents induce antibodies protective against each parental serotype.
- Response of adult human volunteers to oral administration of bovine and bovine/human reassortant rotaviruses.
- Immune response of infants and children to low-passage bovine rotavirus (strain WC3).
- Molecular basis of rotavirus virulence: role of gene segment 4.
- Identification of the two rotavirus genes determining neutralization specificities.
- Maternal antibody-mediated protection against gastroenteritis due to rotavirus in newborn mice is dependent on both serotype and titer of antibody.
- Protection against rotavirus-induced gastroenteritis in a murine model by passively acquired gastrointestinal but not circulating antibodies.
- Identification of the simian rotavirus SA11 genome segment 3 product.
- Rotavirus serotype-specific neutralizing activity in human milk.
- Rotavirus-specific cytotoxic T lymphocytes cross-react with target cells infected with different rotavirus serotypes.
- Rotavirus-specific cytotoxic T lymphocyte response of mice after oral inoculation with candidate rotavirus vaccine strains RRV or WC3.
- Rotavirus-specific cytotoxic T lymphocytes appear at the intestinal mucosal surface after rotavirus infection.
- Rotavirus-specific protein synthesis is not necessary for recognition of infected cells by virus-specific cytotoxic T lymphocytes.
- Noninfectious rotavirus (strain RRV) induces an immune response in mice which protects against rotavirus challenge.
- Passive protection against rotavirus-induced diarrhea by monoclonal antibodies to the heterotypic neutralization domain of VP7 and the VP8 fragment of VP4.
- Rotavirus isolate WI61 representing a presumptive new human serotype.
- Antigenic mapping of the surface proteins of rhesus rotavirus.
- Passive protection against rotavirus-induced diarrhea by monoclonal antibodies to surface proteins vp3 and vp7.
- Presence of three P types (VP4 serotypes) and two G types (VP7 serotypes) among bovine rotavirus strains.
Schools
University of Maryland At Baltimore Professional Schools
Chldns Hospital
Doctors Specialties
- Pediatrics
- Pediatric Infectious Disease
Accepted Insurances
Awards
- Elected Member
- Super Doctor
- Whos Who in Medicine and Healthcare
- Top MD
Education
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Children's Hospital of Philadelphia -
University of Pittsburgh Medical Center -
University of Maryland School of Medicine
Hospital
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Hospital of the University of Pennsylvania
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