Professor, Pediatrics, Perelman School of Medicine
Pediatric Infectious Disease
Dr. Jeffrey M. Bergelson, MD
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Jeffrey M. Bergelson, MD works in the field of Pediatric Infectious Disease. He went to medical school at Perelman School of Medicine at the University of Pennsylvania. Jeffrey Bergelson is a published doctor. He published 87 publications, including: 'Coxsackievirus and adenovirus receptor cytoplasmic and transmembrane domains are not essential for coxsackievirus and adenovirus infection.'
Publications
- Expression of human decay-accelerating factor on intestinal epithelium of transgenic mice does not facilitate infection by the enteral route.
- Specificity of coxsackievirus B3 interaction with human, but not murine, decay accelerating factor (DAF): replacement of a single residue within short consensus repeat...
- Echovirus 7 entry into polarized Caco-2 intestinal epithelial cells involves core components of the autophagy machinery.
- Echovirus 1 entry into polarized caco-2 cells depends on dynamin, cholesterol, and cellular factors associated with macropinocytosis.
- Enterovirus 71 Binding to PSGL-1 on Leukocytes: VP1-145 Acts as a Molecular Switch to Control Receptor Interaction.
- The Crystal Structure of a Coxsackievirus B3-RD Variant and a Refined 9-Angstrom Cryo-Electron Microscopy Reconstruction of the Virus Complexed with Decay-Accelerating...
- Echovirus 7 entry into polarized intestinal epithelial cells requires clathrin and rab7.
- Calcium signals and Calpain-dependent Necrosis are essential for Release of Coxsackievirus B from Polarized Intestinal Epithelial Cells.
- Single amino acid changes in the virus capsid permit coxsackievirus B3 to bind decay accelerating factor.
- Dynamin- and lipid raft-dependent entry of decay-accelerating factor (DAF)-binding and non-DAF-binding coxsackieviruses into nonpolarized cells.
- Tissue-specific deletion of the coxsackievirus and adenovirus receptor protects mice from virus-induced pancreatitis and myocarditis.
- Receptors identified for hand, foot and mouth virus.
- Intercellular junctional proteins as receptors and barriers to virus infection and spread.
- Effect of preexisting immunity on an adenovirus vaccine vector: in vitro neutralization assays fail to predict inhibition by antiviral antibody in vivo.
- Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5.
- Structure-based identification of a major neutralizing site in an adenovirus hexon.
- Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial va...
- Beta1 integrin mediates internalization of mammalian reovirus.
- Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions.
- Adenovirus receptors.
- Interaction with coxsackievirus and adenovirus receptor, but not with decay-accelerating factor (DAF), induces A-particle formation in a DAF-binding coxsackievirus B3 ...
- Glycocalyx restricts adenoviral vector access to apical receptors expressed on respiratory epithelium in vitro and in vivo: role for tethered mucins as barriers to lum...
- The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction.
- Efficient transduction of human monocyte-derived dendritic cells by chimpanzee-derived adenoviral vector.
- Structure and chromosomal localization of the murine coxsackievirus and adenovirus receptor gene.
- A zebrafish coxsackievirus and adenovirus receptor homologue interacts with coxsackie B virus and adenovirus.
- Interaction with decay-accelerating factor facilitates coxsackievirus B infection of polarized epithelial cells.
- Soluble coxsackievirus adenovirus receptor is a putative inhibitor of adenoviral gene transfer in the tumor milieu.
- Novel, chimpanzee serotype 68-based adenoviral vaccine carrier for induction of antibodies to a transgene product.
- VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment.
- Picornavirus entry.
- rab5 GTPase regulates adenovirus endocytosis.
- The mechanism of the growth-inhibitory effect of coxsackie and adenovirus receptor (CAR) on human bladder cancer: a functional analysis of car protein structure.
- Trans-complementation of vector replication versus Coxsackie-adenovirus-receptor overexpression to improve transgene expression in poorly permissive cancer cells.
- Loss of adenoviral receptor expression in human bladder cancer cells: a potential impact on the efficacy of gene therapy.
- Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardio...
- The dual impact of coxsackie and adenovirus receptor expression on human prostate cancer gene therapy.
- Fetal muscle gene transfer is not enhanced by an RGD capsid modification to high-capacity adenoviral vectors.
- Regulation of the T cell receptor genes: the beginnings of the evidence.
- Integrin-ligand binding. Do integrins use a ''MIDAS touch'' to grasp an Asp?
- Structure determination of echovirus 1.
- Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human ...
- Determination of molecules regulating gene delivery using adenoviral vectors in ovarian carcinomas.
- Receptors mediating adenovirus attachment and internalization.
- Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution.
- Crystal structure of the I domain from integrin alpha2beta1.
- Defining CAR as a cellular receptor for the avian adenovirus CELO using a genetic analysis of the two viral fibre proteins.
- Canine adenovirus type 2 attachment and internalization: coxsackievirus-adenovirus receptor, alternative receptors, and an RGD-independent pathway.
- Cellular expression of a GPI-linked T cell activation protein.
- High-efficiency gene transfer into ex vivo expanded human hematopoietic progenitors and precursor cells by adenovirus vectors.
- Determinants of ligand binding specificity of the alpha(1)beta(1) and alpha(2)beta(1) integrins.
- Echoviruses 1 and 8 are closely related genetically, and bind to similar determinants within the VLA-2 I domain.
- The coxsackie-adenovirus receptor (CAR) is used by reference strains and clinical isolates representing all six serotypes of coxsackievirus group B and by swine vesicu...
- CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts.
- Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expre...
- The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F.
- Identification of the integrin VLA-2 as a receptor for echovirus 1.
- Decay-accelerating factor (CD55), a glycosylphosphatidylinositol-anchored complement regulatory protein, is a receptor for several echoviruses.
- Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia.
- Molecular determinants of adenovirus serotype 5 fibre binding to its cellular receptor CAR.
- Coxsackievirus and adenovirus receptor cytoplasmic and transmembrane domains are not essential for coxsackievirus and adenovirus infection.
- Temporally regulated expression patterns following in utero adenovirus-mediated gene transfer.
- Clinical coxsackievirus B isolates differ from laboratory strains in their interaction with two cell surface receptors.
- The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms.
- The mouse VLA-2 homologue supports collagen and laminin adhesion but not virus binding.
- The I domain is essential for echovirus 1 interaction with VLA-2.
- Echovirus 1 interaction with the human very late antigen-2 (integrin alpha2beta1) I domain. Identification of two independent virus contact sites distinct from the met...
- The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction.
- Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5.
- Integrins as receptors for virus attachment and cell entry.
- Integrin alpha 2 cytoplasmic domain deletion effects: loss of adhesive activity parallels ligand-independent recruitment into focal adhesions.
- Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2.
- Echovirus 1 interaction with the isolated VLA-2 I domain.
- Retargeting the coxsackievirus and adenovirus receptor to the apical surface of polarized epithelial cells reveals the glycocalyx as a barrier to adenovirus-mediated g...
- The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses.
- Coxsackievirus B3 adapted to growth in RD cells binds to decay-accelerating factor (CD55).
- Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting.
- Tissue tropism of recombinant coxsackieviruses in an adult mouse model.
- Chimpanzee adenovirus CV-68 adapted as a gene delivery vector interacts with the coxsackievirus and adenovirus receptor.
- A novel gain-of-function mutation of the integrin alpha2 VWFA domain.
- High-efficiency gene transfer to primary T lymphocytes by recombinant adenovirus vectors.
- Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family.
- Virus interactions with mucosal surfaces: alternative receptors, alternative pathways.
- CAR: a virus receptor within the tight junction.
- Poliovirus entry into human brain microvascular cells requires receptor-induced activation of SHP-2.
- New (fluorescent) light on poliovirus entry.
Schools
Perelman School of Medicine University of Pennsylvania
Children39s Hospital Boston
Doctors Specialties
- Pediatric Infectious Disease Medicine
- Pediatric Infectious Disease
Accepted Insurances
- Aetna
- Amerigroup (Wellpoint)
- Local Value Network EPO
- Local Value Network HMO
- Local Value Network HMO+
- Local Value Network POS+
- Local Value Network PPO
- Personal Choice PPO
- Regional Pref Network EPO
- Regional Pref Network HMO
- Regional Pref Network HMO+
- Regional Pref Network POS+
- Regional Pref Network PPO
- Blue Card PPO
- Great West Healthcare-Cigna PPO
- Commercial Insurance Company
- Geisinger Health Plan
- HealthPartners
- Community Blue PPO
- Advance EPO
- Direct Access
- Horizon Blue Cross Blue Shield HMO
- Horizon Blue Cross Blue Shield POS
- Horizon Blue Cross Blue Shield PPO
- Choice Care PPO
- Keystone Health Plan East HMO
- Medicare MCR
- MultiPlan PPO
- Freedom Plan
- QualCare HMO
- QualCare PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- Oxford Liberty
- United Healthcare
Education
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Boston Children's Hospital -
UCSF -
Perelman School of Medicine at the University of Pennsylvania
Hospital
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Hospital of the University of Pennsylvania
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