Professor, Pediatrics, Yale University School of Medicine
Neonat/Perinatology
Dr. Patrick G. Gallagher, MD
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Patrick Gallagher is an expert in the field of Neonat/Perinatology. He graduated from Northeast Ohio Medical University. He received 2 awards: "Elected Member" and "Fellow (FAAP)". Patrick G. Gallagher, MD is a published doctor. He has 71 publications published. The most current publication "Human and murine erythropoiesis."
Publications
- Human and murine erythropoiesis.
- Piezo Proteins: Regulators of Mechanosensation and Other Cellular Processes.
- Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes.
- One size does not fit all: why universal decolonization strategies to prevent methicillin-resistant Staphylococcus aureus colonization and infection in adult intensive...
- Global transcriptome analyses of human and murine terminal erythroid differentiation.
- Probing large conformational rearrangements in wild-type and mutant spectrin using structural mass spectrometry.
- Nonstochastic reprogramming from a privileged somatic cell state.
- Abnormalities of the erythrocyte membrane.
- Whole exome sequencing identifies a novel somatic mutation in MMP8 associated with a t(1;22)-acute megakaryoblastic leukemia.
- Late-onset Leclercia adecarboxylata sepsis in a premature neonate.
- Disorders of red cell volume regulation.
- Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis.
- A de novo band 3 mutation in hereditary spherocytosis.
- Genetic diagnosis of neuroacanthocytosis disorders using exome sequencing.
- HbA2: at the borderline of the KLF.
- Granulicatella adiacens and Early-Onset Sepsis in Neonate.
- Patterns of histone H3 lysine 27 monomethylation and erythroid cell-type specific gene expression.
- Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation.
- Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S.
- Erythrocyte peripheral type benzodiazepine receptor/voltage-dependent anion channels are upregulated by Plasmodium falciparum.
- Perinatal onset mevalonate kinase deficiency.
- Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.
- Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo.
- Bi-allelic deletions within 13q14 and transient trisomy 21 with absence of GATA1s in pediatric acute megakaryoblastic leukemia.
- Partial Exchange Transfusion for Polycythemia Hyperviscosity Syndrome.
- Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosis.
- A comprehensive model of the spectrin divalent tetramer binding region deduced using homology modeling and chemical cross-linking of a mini-spectrin.
- Functional analysis of a novel cis-acting regulatory region within the human ankyrin gene (ANK-1) promoter.
- Determinants of erythrocyte hydration.
- A fused alpha-beta "mini-spectrin" mimics the intact erythrocyte spectrin head-to-head tetramer.
- The GPA-dependent, spherostomatocytosis mutant AE1 E758K induces GPA-independent, endogenous cation transport in amphibian oocytes.
- Chromatin architecture and transcription factor binding regulate expression of erythrocyte membrane protein genes.
- Sites of regulated phosphorylation that control K-Cl cotransporter activity.
- Imaging of the diffusion of single band 3 molecules on normal and mutant erythrocytes.
- Canine elliptocytosis due to a mutant beta-spectrin.
- An insulator with barrier-element activity promotes alpha-spectrin gene expression in erythroid cells.
- Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2.
- Red cell membrane: past, present, and future.
- Ankyrin-linked hereditary spherocytosis in an African-American kindred.
- Matched case-control analysis of polymicrobial bloodstream infection in a neonatal intensive care unit.
- Structural and functional effects of hereditary hemolytic anemia-associated point mutations in the alpha spectrin tetramer site.
- Changing patterns in neonatal Escherichia coli sepsis and ampicillin resistance in the era of intrapartum antibiotic prophylaxis.
- Population analysis of the alpha hemoglobin stabilizing protein (AHSP) gene identifies sequence variants that alter expression and function.
- Novel role for EKLF in megakaryocyte lineage commitment.
- Picture of the month. Blueberry muffin baby (extramedullary hematopoiesis) due to congenital cytomegalovirus infection.
- An 11-amino acid beta-hairpin loop in the cytoplasmic domain of band 3 is responsible for ankyrin binding in mouse erythrocytes.
- Erythrocyte disorders in the perinatal period.
- A decline in the frequency of neonatal exchange transfusions and its effect on exchange-related morbidity and mortality.
- A complex splicing defect associated with homozygous ankyrin-deficient hereditary spherocytosis.
- Pathogenic proline mutation in the linker between spectrin repeats: disease caused by spectrin unfolding.
- Antibiotic-resistant organisms in the neonatal intensive care unit.
- Aplastic crisis revealing the diagnosis of Hb Evans [alpha62(E11)Val-->Met, GTG-->ATG (alpha2)] in a Hispanic kindred: case report and review.
- Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice.
- A novel splicing mutation of the alpha-spectrin gene in the original hereditary pyropoikilocytosis kindred.
- GATA-1 and Oct-1 are required for expression of the human alpha-hemoglobin-stabilizing protein gene.
- Hematologically important mutations: ankyrin variants in hereditary spherocytosis.
- Vancomycin-resistant enterococcal bacteremia and necrotizing enterocolitis in a preterm neonate.
- Seventy-five years of neonatal sepsis at Yale: 1928-2003.
- Red cell membrane disorders.
- Sequences downstream of the erythroid promoter are required for high level expression of the human alpha-spectrin gene.
- Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element.
- Hereditary elliptocytosis: spectrin and protein 4.1R.
- Update on the clinical spectrum and genetics of red blood cell membrane disorders.
- Conjunctival colonization of infants hospitalized in a neonatal intensive care unit: a longitudinal analysis.
- Mutation of a highly conserved isoleucine disrupts hydrophobic interactions in the alpha beta spectrin self-association binding site.
- Variegated expression from the murine band 3 (AE1) promoter in transgenic mice is associated with mRNA transcript initiation at upstream start sites and can be suppres...
- Altered erythrocyte endothelial adherence and membrane phospholipid asymmetry in hereditary hydrocytosis.
- Regulation of erythrocyte membrane protein gene expression.
- Erythroid expression of the human alpha-spectrin gene promoter is mediated by GATA-1- and NF-E2-binding proteins.
- Cytogenomic mapping and bioinformatic mining reveal interacting brain expressed genes for intellectual disability.
Schools
Northeastern Ohio University College of Medicine
Children39s Hospital Med Center
Chldns Hospital Med CtrU Cincinnati
Yale University School Of Med
Doctors Specialties
- Neonatal Medicine
- Neonat/Perinatology
Accepted Insurances
Awards
- Elected Member
- Fellow (FAAP)
Education
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Yale-New Haven Hospital -
Cincinnati Children's Hospital Medical Center -
Northeast Ohio Medical University
Hospital
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Yale-New Haven Hospital
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