Professor, Pediatrics, Genetics, and Investigative Medicine, Yale University School of Medicine
Neonat/Perinatology
Dr. Jeffrey R. Gruen, MD
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Jeffrey Gruen works in the field of Neonat/Perinatology. He graduated from Tulane University School of Medicine. Doctor Jeffrey R. Gruen, MD is a published doctor and has 65 publications published. The lastest was: 'Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization.'
Publications
- The regulatory element READ1 epistatically influences reading and language, with both deleterious and protective alleles.
- Family income, parental education and brain structure in children and adolescents.
- Language Impairment and Dyslexia Genes Influence Language Skills in Children With Autism Spectrum Disorders.
- Characterization of the DYX2 locus on chromosome 6p22 with reading disability, language impairment, and IQ.
- The NIH Toolbox Cognition Battery: Results from a large normative developmental sample (PING).
- Genome-Wide Association Study of Shared Components of Reading Disability and Language Impairment.
- Alleles of a Polymorphic ETV6 Binding Site in DCDC2 Confer Risk of Reading and Language Impairment.
- Imaging-genetics in dyslexia: Connecting risk genetic variants to brain neuroimaging and ultimately to reading impairments.
- Prenatal Exposure to Nicotine and Impaired Reading Performance.
- Genetic influences of resting state fMRI activity in language-related brain regions in healthy controls and schizophrenia patients: a pilot study.
- Variants in the DYX2 locus are associated with altered brain activation in reading-related brain regions in subjects with reading disability.
- DCDC2 genetic variants and susceptibility to developmental dyslexia.
- A highly sensitive, high-throughput assay for the detection of Turner syndrome.
- The impact of environmental and genetic factors on neonatal late-onset sepsis.
- A dyslexia-associated variant in DCDC2 changes gene expression.
- Pleiotropic effects of DCDC2 and DYX1C1 genes on language and mathematics traits in nuclear families of developmental dyslexia.
- Progress towards a cellular neurobiology of reading disability.
- The genetic susceptibility to respiratory distress syndrome.
- Cognitive flexibility is associated with KIBRA variant and modulated by recent tobacco use.
- Genetic contribution to patent ductus arteriosus in the premature newborn.
- The human lexinome: genes of language and reading.
- Polymorphism of DCDC2 Reveals Differences in Cortical Morphology of Healthy Individuals-A Preliminary Voxel Based Morphometry Study.
- Management of dyslexia, its rationale, and underlying neurobiology.
- Genetic approaches to complications of prematurity.
- Genetic susceptibility to retinopathy of prematurity.
- The genetics of bronchopulmonary dysplasia.
- DCDC2 is associated with reading disability and modulates neuronal development in the brain.
- Detection of Turner syndrome using high-throughput quantitative genotyping.
- Prss16 is not required for T-cell development.
- Seven new cases of familial isolated bladder exstrophy and epispadias complex (BEEC) and review of the literature.
- Schizophrenia-risk variant rs6994992 in the neuregulin-1 gene on brain developmental trajectories in typically developing children.
- Associations of Prenatal Nicotine Exposure and the Dopamine Related Genes ANKK1 and DRD2 to Verbal Language.
- Differential expression of novel Gs alpha signal transduction protein cDNA species.
- Recombinations defining centromeric and telomeric borders for the hereditary haemochromatosis locus.
- Evolving views of the major histocompatibility complex.
- Haplotype analysis of hemochromatosis: evaluation of different linkage-disequilibrium approaches and evolution of disease chromosomes.
- Physical and genetic mapping of the telomeric major histocompatibility complex region in man and relevance to the primary hemochromatosis gene (HFE).
- Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection.
- Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22.
- The genomic organization of the histone clusters on human 6p21.3.
- Genetic influences of cortical gray matter in language-related regions in healthy controls and schizophrenia.
- FISH-Mapped CEPH YACs spanning 0 to 46 cM on human chromosome 6.
- An integrated approach for identifying and mapping human genes.
- Cloning of a new "finger" protein gene (ZNF173) within the class I region of the human MHC.
- Human GABA(B) receptor 1 gene: eight novel sequence variants.
- Genetics of childhood disorders: VII. Cloning genes of interest.
- Polymorphisms in the gene encoding thymus-specific serine protease in the extended HLA complex: a potential candidate gene for autoimmune and HLA-associated diseases.
- Peaks of linkage are localized by a BAC/PAC contig of the 6p reading disability locus.
- Human MHC class III and IV genes and disease associations.
- A transcription map of the major histocompatibility complex (MHC) class I region.
- Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization.
- Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus.
- Evidence for linkage and association with reading disability on 6p21.3-22.
- A detailed physical map of the 6p reading disability locus, including new markers and confirmation of recombination suppression.
- Expression, genomic structure and mapping of the thymus specific protease prss16: a candidate gene for insulin dependent diabetes mellitus susceptibility.
- TDT-association analysis of EKN1 and dyslexia in a Colorado twin cohort.
- CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, an...
- A transcription map of the 6p22.3 reading disability locus identifying candidate genes.
- Familial and genetic susceptibility to major neonatal morbidities in preterm twins.
- Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples.
- Guideline for data analysis of genomewide association studies.
- Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region.
- Investigation of the DCDC2 intron 2 deletion/compound short tandem repeat polymorphism in a large German dyslexia sample.
- Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence.
Schools
Northwestern Center Feinberg School of Medicine
Tulane University of Louisiana
Yale New Haven Hospital
Doctors Specialties
- Neonatal Medicine
- Neonat/Perinatology
Accepted Insurances
Education
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Yale-New Haven Hospital -
Tulane University School of Medicine
Hospital
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Yale-New Haven Hospital
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