Physician

Hematology

Lyuba Varticovski, MD is an expert in the field of Hematology. Doctor Lyuba Varticovski, MD is a published doctor and has 81 publications published. The lastest was: 'The role of phosphoinositide 3-kinase in taurocholate-induced trafficking of ATP-dependent canalicular transporters in rat liver.'

Publications

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• P6981, an arylstibonic acid, is a novel low nanomolar inhibitor of cAMP response element-binding protein binding to DNA.
• Dietary Energy Balance Modulates Epithelial-to-Mesenchymal Transition and Tumor Progression in Murine Claudin-Low and Basal-like Mammary Tumor Models.
• Genome-Wide Chromatin Landscape Transitions Identify Novel Pathways in Early Commitment to Osteoblast Differentiation.
• Water-soluble HPMA copolymer-wortmannin conjugate retains phosphoinositide 3-kinase inhibitory activity in vitro and in vivo.
• Mitogenic signaling by cyclic adenosine monophosphate in chromaffin cells involves phosphatidylinositol 3-kinase activation.
• Dynamin inhibits phosphatidylinositol 3-kinase in hematopoietic cells.
• Probing fibroblast growth factor dimerization and role of heparin-like glycosaminoglycans in modulating dimerization and signaling.
• The src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activa...
• Inactivation of wild-type BCR/ABL tyrosine kinase in hematopoietic cells by mild hyperthermia.
• Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells.
• Expression of tie1 and tie2 proteins during reendothelialization in balloon-injured rat carotid artery.
• Phosphoinositide 3-kinase lipid products regulate ATP-dependent transport by sister of P-glycoprotein and multidrug resistance associated protein 2 in bile canalicular...
• The role of phosphoinositide 3-kinase in taurocholate-induced trafficking of ATP-dependent canalicular transporters in rat liver.
• Effect of a xanthine analog on human hepatocellular carcinoma cells (Alexander) in culture and in xenografts in SCID mice.
• Tyrosine phosphorylation of the CD3-epsilon subunit of the T cell antigen receptor mediates enhanced association with phosphatidylinositol 3-kinase in Jurkat T cells.
• Evidence for phosphatidylinositol 3-kinase-dependent T cell antigen receptor (TCR) signal transduction.
• Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase.
• Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate...
• BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats.
• PI 3-kinase activation in BCR/abl-transformed hematopoietic cells does not require interaction of p85 SH2 domains with p210 BCR/abl.
• Studies on fenestral contraction in rat liver endothelial cells in culture.
• Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression.
• Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells.
• In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle.
• Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation.
• Naturally occurring ether-linked phosphatidylcholine activates phosphatidylinositol 3-kinase and stimulates cell growth.
• Serine-rich region of the IL-2 receptor beta-chain is required for activation of phosphatidylinositol 3-kinase.
• Phosphatidylinositol 3-kinase activity in murine erythroleukemia cells during DMSO-induced differentiation.
• Phorbol ester treatment inhibits phosphatidylinositol 3-kinase activation by, and association with, CD28, a T-lymphocyte surface receptor.
• Association of phosphatidylinositol 3-kinase with SHC in chronic myelogeneous leukemia cells.
• Role of PI 3-kinase in mitogenesis.
• Biosynthesis of porphyrin precursors: kinetic studies on mammalian L-alanine: gamma,delta-dioxovaleric acid aminotransferase.
• Biosynthesis of porphyrin precursors. Purification and characterization of mammalian L-alanine:gamma,delta-dioxovaleric acid aminotransferase.
• Signal transduction through the EGF receptor transfected in IL-3-dependent hematopoietic cells.
• Anti-platelet and anti-DNA IgM in Waldenström macroglobulinemia and ITP.
• Paradoxical stimulation of both lipocortin and prostaglandin production in human amnion cells by dexamethasone.
• The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase.
• Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae.
• Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C.
• Signal transduction and phosphoinositide metabolism in liver.
• Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.
• Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase.
• Role of protein-tyrosine kinases in cellular transformation.
• Platelet-derived growth factor activates membrane-associated phosphatidylinositol 3-kinase and mediates its translocation from the cytosol. Detection of enzyme activit...
• Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes.
• Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer.
• Chaperone-mediated autophagy is required for tumor growth.
• Schedule-dependent synergy of histone deacetylase inhibitors with DNA damaging agents in small cell lung cancer.
• Prolonged drug selection of breast cancer cells and enrichment of cancer stem cell characteristics.
• The arylstibonic acid compound NSC13746 disrupts B-ZIP binding to DNA in living cells.
• Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia.
• Microenvironmental modulation of asymmetric cell division in human lung cancer cells.
• A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas.
• Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.
• microRNA expression in the biology, prognosis, and therapy of Waldenström macroglobulinemia.
• HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair.
• The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane.
• Obesity accelerates mouse mammary tumor growth in the absence of ovarian hormones.
• Rapamycin delays growth of Wnt-1 tumors in spite of suppression of host immunity.
• Lung cancer stem cells.
• Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1.
• Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics.
• Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance.
• A phase II clinical trial with cytotropic heterogeneous molecular lipids (CHML) for patients with hepatic malignancies.
• Accelerated preclinical testing using transplanted tumors from genetically engineered mouse breast cancer models.
• Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1.
• The obesity-cancer link: lessons learned from a fatless mouse.
• Harnessing genetically engineered mouse models for preclinical testing.
• Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-...
• Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and...
• Accelerated tumor formation in a fatless mouse with type 2 diabetes and inflammation.
• The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress.
• Computerized case history - an effective tool for management of patients and clinical trials.
• Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray.
• The knockout mouse project.
• A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase.
• Opposing effect of angiopoietin-1 on VEGF-mediated disruption of endothelial cell-cell interactions requires activation of PKC beta.
• Mechanisms by which cAMP increases bile acid secretion in rat liver and canalicular membrane vesicles.
• Mechanism by which cAMP activates PI3-kinase and increases bile acid secretion in WIF-B9 cells.
• NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hy...

Schools

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• University of The Valley Division of Health Science

• Albany Memorial Hospital

• New England Med Center Hospital

Doctors Specialties

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• Hematology

Accepted Insurances

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Education

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• Tufts Medical Center
• Albany Medical Center
• Universidad del Valle Health Sciences

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