Physician

Hematology

Lozier practices Hematology. Doctor Jay N. Lozier, MD is a published doctor and has 43 publications published. The lastest was: 'Gut epithelial cells as targets for gene therapy of hemophilia.'

Publications

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• York platelet syndrome is a CRAC channelopathy due to gain-of-function mutations in STIM1.
• The intron-22-inverted F8 locus permits intracellular factor VIII synthesis, explaining its low inhibitor risk and suggesting a role for pharmacogenomics.
• Inhibitory effect of nitrite on coagulation processes demonstrated by thrombelastography.
• Recombinant Human Factor VIIa for Alveolar Hemorrhage Following Allogeneic Stem Cell Transplantation.
• Acquired haemophilia A after stem cell transplant for sickle cell disease: treatment with recombinant porcine factor VIII (OBI-1) and tolerance induction with rituxima...
• Animal Models of Hemophilia and Related Bleeding Disorders.
• Elevations in D-dimer and C-reactive protein are associated with the development of osteonecrosis of the hip in HIV-infected adults.
• Treatment of high-risk venous thrombosis patients using low-dose intraclot injections of recombinant tissue plasminogen activator and regional anticoagulation.
• Familial secondary erythrocytosis due to increased oxygen affinity is caused by destabilization of the T state of hemoglobin Brigham (α(2) β(2) (Pro100Leu) ).
• Eltrombopag and improved hematopoiesis in refractory aplastic anemia.
• Gene therapy for haemophilia: prospects and challenges to prevent or reverse inhibitor formation.
• Spray: single-donor plasma product for room temperature storage.
• Low-Dose, Once-Daily, Intraclot Injections of Alteplase for Treatment of Acute Deep Venous Thrombosis.
• Thromboembolic adverse events after use of recombinant human coagulation factor VIIa.
• Rapid Kupffer cell death after intravenous injection of adenovirus vectors.
• Mapping of genes that control the antibody response to human factor IX in mice.
• Severe pulmonary pathology after intravenous administration of vectors in cirrhotic rats.
• The Chapel Hill hemophilia A dog colony exhibits a factor VIII gene inversion.
• Sustained high-level expression of human factor IX (hFIX) after liver-targeted delivery of recombinant adeno-associated virus encoding the hFIX gene in rhesus macaques.
• Toxicity of a first-generation adenoviral vector in rhesus macaques.
• Adenoviral vectors do not induce, inhibit, or potentiate human platelet aggregation.
• Complete amino acid sequence of human plasma beta 2-glycoprotein I.
• Safety profile of porcine factor VIII and its use as hospital and home-therapy for patients with haemophilia-A and inhibitors: the results of an international survey.
• New perspectives on the coagulation cascade.
• Porcine factor VIII therapy in patients with congenital hemophilia and inhibitors: efficacy, patient selection, and side effects.
• Molecular basis of hemophilia.
• Haemophilia B: database of point mutations and short additions and deletions.
• Use of porcine factor VIII for surgical procedures in hemophilia A patients with inhibitors.
• Clinical and molecular characterization of a re-established line of sheep exhibiting hemophilia A.
• Gene therapy of the hemophilias.
• Thrombocytopenia and hemostatic disorders in chronic graft versus host disease.
• Neutralizing antibodies to therapeutic enzymes: considerations for testing, prevention and treatment.
• A case-control study reveals immunoregulatory gene haplotypes that influence inhibitor risk in severe haemophilia A.
• Gene therapy and the hemophilias.
• Interleukin-2 cycling causes transient increases in high-sensitivity C-reactive protein and D-dimer that are not associated with plasma HIV-RNA levels.
• Factor IX New London: substitution of proline for glutamine at position 50 causes severe hemophilia B.
• Efficient transfection of primary cells in a canine hemophilia B model using adenovirus-polylysine-DNA complexes.
• Gut epithelial cells as targets for gene therapy of hemophilia.
• The rhesus macaque as an animal model for hemophilia B gene therapy.
• Intravenous administration of replication-incompetent adenovirus to rhesus monkeys induces thrombocytopenia by increasing in vivo platelet clearance.
• Adenovirus-mediated expression of human coagulation factor IX in the rhesus macaque is associated with dose-limiting toxicity.
• Paraneoplastic granulocytosis in metastatic melanoma.

Schools

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• Indiana University School of Medicine

Doctors Specialties

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• Hematology

Accepted Insurances

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Education

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• University of North Carolina Hospitals

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