Associate Professor, Pediatrics, U of WA Sch of Med
Pediatric Hematology & Oncology
Dr. Leslie S. Kean, MD
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Leslie Kean works in the field of Pediatric Hematology & Oncology. She graduated from Emory University School of Medicine. Emory University School of Medicine has a rank of 23 in research and a 42 in primary care Leslie S. Kean is a published doctor and has 25 publications published. The lastest was: 'Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3.'
Publications
- Immune parameter analysis of children with sickle cell Disease on hydroxycarbamide or chronic transfusion therapy.
- Persistence of Virus Reservoirs in ART-Treated SHIV-Infected Rhesus Macaques after Autologous Hematopoietic Stem Cell Transplant.
- In vivo T cell costimulation blockade with abatacept for Acute graft-versus-host disease prevention: a first-in-disease trial.
- Immunogenetic Management Software: a new tool for visualization and analysis of complex immunogenetic datasets.
- Significant mobilization of both conventional and regulatory T Cells with AMD3100.
- Alloimmunization to transfused HOD red blood cells is not increased in mice with sickle cell Disease.
- GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T Cells as a reservoir of breakthrough T-Cell proliferation ...
- Expansion of effector memory TCR Vbeta4+ CD8+ T Cells is associated with latent infection-mediated resistance to transplantation tolerance.
- Infusion of stably immature monocyte-derived dendritic Cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques.
- Chimerism and cure: hematologic and pathologic correction of murine sickle cell Disease.
- A cure for murine sickle cell Disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-m...
- Heterologous Immunity Triggered by a Single, Latent Virus in Mus musculus: Combined Costimulation- and Adhesion- Blockade Decrease Rejection.
- Campomelic syndrome and deletion of SOX9.
- Expanded nonhuman primate tregs exhibit a unique gene expression signature and potently downregulate alloimmune responses.
- Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3.
- CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model.
- Transplant tolerance in non-human primates: progress, current challenges and unmet needs.
- An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching.
- Murine and math models for the level of stable mixed chimerism to cure beta-thalassemia by nonmyeloablative bone marrow transplantation.
- NK Cells rapidly reject allogeneic bone marrow in the spleen through a perforin- and Ly49D-dependent, but NKG2D-independent mechanism.
- NK Cells mediate costimulation blockade-resistant rejection of allogeneic stem Cells during nonmyeloablative transplantation.
- Induction of chimerism in rhesus macaques through stem Cell transplant and costimulation blockade-based immunosuppression.
- Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with mini...
- Comparison of mechanisms of Anemia in mice with sickle cell disease and beta-thalassemia: peripheral destruction, ineffective erythropoiesis, and phospholipid scrambla...
Schools
Emory University
Emory University School Of Med
Conditions Treated
- Acute Leukemia
- Anemia
- Graft vs Host Disease
- Myeloproliferative Disorders
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Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Education
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Emory University -
Emory University School of Medicine
Hospital
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Grady Memorial Hospital
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