Professor Pediatrics, Emory University School of Medicine
Pediatric Hematology & Oncology
Dr. Tobey J. MacDonald, MD
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Tobey J. MacDonald practices Pediatric Hematology & Oncology. He researched medicine at Weill Cornell Medical College of Cornell University. Weill Cornell Medical College of Cornell University is ranked 18/49 in Research/PrimaryCare. He received awards:"Regional Top Doctor" and "Top Doctors- Pediatric Hematology Oncology". Tobey J. MacDonald is also a published physician. He has 65 publication published. The most recent publication is: Detection of brain tumor invasion and micrometastasis in vivo by expression of enhanced green fluorescent protein.
Publications
- Successful Retreatment of a Child with a Refractory Brainstem Ganglioglioma with Vemurafenib.
- A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in Medulloblastoma.
- Dasatinib suppression of Medulloblastoma survival and migration is markedly enhanced by combining treatment with the aurora kinase inhibitor AT9283.
- EphrinB1 expression is dysregulated and promotes oncogenic signaling in Medulloblastoma.
- Guiding intracortical Brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres.
- The rationale for targeted therapies in Medulloblastoma.
- Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes.
- Phase II study of cilengitide in the treatment of refractory or relapsed high-grade Gliomas in children: A report from the Children's Oncology Group.
- Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes Medulloblastoma migration.
- Response to bevacizumab, irinotecan, and temozolomide in children with relapsed Medulloblastoma: a multi-institutional experience.
- Prolonged survival after treatment of diffuse intrinsic pontine glioma with radiation, temozolamide, and bevacizumab: report of 2 cases.
- VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in Medulloblastoma cells.
- Phase I study of tandem high-dose chemotherapy with autologous peripheral blood stem cell rescue for children with recurrent Brain tumors: a Pediatric Blood and Marrow...
- Identification of transcriptional regulatory networks specific to pilocytic Astrocytoma.
- Secretome Signature of Invasive Glioblastoma Multiforme.
- Arsenic trioxide inhibits human Cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway.
- Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of Medulloblastoma cells.
- Characterization of signaling function and expression of HLA class I molecules in Medulloblastoma.
- Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of Brainstem glioma.
- Heterozygosity for Pten promotes tumorigenesis in a mouse model of Medulloblastoma.
- Detection of human herpesvirus-6 in adult central Nervous system tumors: predominance of early and late viral antigens in glial tumors.
- Imatinib blocks migration and invasion of Medulloblastoma cells by concurrently inhibiting activation of platelet-derived growth factor receptor and transactivation of...
- Aggressive infantile embryonal tumors.
- IGFBP2 is overexpressed by pediatric malignant Astrocytomas and induces the repair enzyme DNA-PK.
- Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood Gliomas.
- Feasibility of metronomic maintenance chemotherapy following high-dose chemotherapy for malignant central Nervous system tumors.
- Phase I clinical trial of cilengitide in children with refractory Brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012.
- Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with Brain tumors: a pediatric Brain tumor consortium report.
- Outcome for children <4 years of age with malignant central Nervous system tumors treated with high-dose chemotherapy and autologous stem cell rescue.
- Progression-associated genes in Astrocytoma identified by novel microarray gene expression data reanalysis.
- An analysis of SEER data of increasing risk of secondary malignant neoplasms among long-term survivors of childhood Brain tumors.
- Phase II study of high-dose chemotherapy before radiation in children with newly diagnosed high-grade astrocytoma: final analysis of Children's Cancer Group Study 9933.
- An expression signature classifies chemotherapy-resistant pediatric osteoSarcoma.
- Current treatment of Medulloblastoma: recent advances and future challenges.
- Overexpression of the EGFR/FKBP12/HIF-2alpha pathway identified in childhood Astrocytomas by angiogenesis gene profiling.
- Advances in the diagnosis, molecular genetics, and treatment of pediatric embryonal CNS tumors.
- Detection of Brain tumor invasion and micrometastasis in vivo by expression of enhanced green fluorescent protein.
- The Ewing tumor family of peripheral primitive neuroectodermal tumors expresses human gastrin-releasing peptide.
- Medulloblastoma and primitive neuroectodermal tumors.
- Treatment of high-grade glioma in children and adolescents.
- Radial glia Cells are candidate stem Cells of ependymoma.
- Preferential susceptibility of Brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist.
- Urokinase induces receptor mediated Brain tumor cell migration and invasion.
- Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central Nervous system tumors.
- Phase I trial of pirfenidone in children with neurofibromatosis 1 and plexiform neurofibromas.
- Phase I trial of lenalidomide in pediatric patients with recurrent, refractory, or progressive primary CNS tumors: Pediatric Brain Tumor Consortium study PBTC-018.
- Antisense to integrin alpha v inhibits growth and induces apoptosis in Medulloblastoma cells.
- Phase II study of thalidomide and radiation in children with newly diagnosed Brain stem gliomas and glioblastoma multiforme.
- Wnt10b induces chemotaxis of osteoSarcoma and correlates with reduced survival.
- CNS germ Cell tumor (CNSGCT) of childhood: presentation and delayed diagnosis.
- Expression profiling of Medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease.
- Objective response of multiply recurrent low-grade Gliomas to bevacizumab and irinotecan.
- The use of gene expression analysis to gain insights into signaling mechanisms of metastatic Medulloblastoma.
- Medulloblastoma: present concepts of stratification into risk groups.
- Pediatric high-grade glioma: molecular genetic clues for innovative therapeutic approaches.
- Medulloblastoma in childhood: new biological advances.
- A novel role of HLA class I in the pathology of Medulloblastoma.
- Detection of human herpesvirus-6 variants in pediatric Brain tumors: association of viral antigen in low grade gliomas.
- ERK activation of p21 activated kinase-1 (Pak1) is critical for Medulloblastoma cell migration.
- Protein profiling of formalin fixed paraffin embedded tissue: Identification of potential biomarkers for pediatric Brainstem glioma.
- Neurofibromatosis-2 and spinal cord ependymomas: Report of two cases and review of the literature.
- Proteomic profiling of cerebrospinal fluid identifies prostaglandin D2 synthase as a putative biomarker for pediatric medulloblastoma: A pediatric Brain tumor consorti...
- A MCP1 fusokine with CCR2-specific tumoricidal activity.
- Clonal selection drives genetic divergence of metastatic Medulloblastoma.
Schools
Weill Cornell Medical College
Children39s Hospital Los Angeles
Conditions Treated
- Anemia
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
- Brain Cancer
- Neutropenia
- View All
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Amerigroup (Wellpoint)
- Blue Card PPO
- Blue Choice HMO
- Blue Choice Option POS
- Blue Open Access POS
- Direct Access w/HSA
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Open Access Plus
- Commercial Insurance Company
- Coventry Health Care
- Coventry Health Care of Delaware PPO
- First Health (Coventry Health Care) PPO
- Golden Rule
- Preferred PPO
- Kaiser Permanente
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Awards
- Regional Top Doctor
- Top Doctors- Pediatric Hematology Oncology
Education
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Children's Hospital of Los Angeles -
Weill Cornell Medical College of Cornell University
Hospital
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Children's Healthcare of Atlanta -
Emory University Hospital
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