Professor of Pathology (Pediatrics), Boston Children's Hospital

Pathology

Leslie Silberstein practices Pathology. He received 1 awards: "Elected Member". Leslie Silberstein is a published MD. He has 34 publications published. The most current publication "The science behind the hypoxic niche of hematopoietic stem and progenitors."

Publications

---

• Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis.
• The science behind the hypoxic niche of hematopoietic stem and progenitors.
• Cell therapy product administration and safety: data capture and analysis from the Production Assistance for Cellular Therapies (PACT) program.
• Fgd5 identifies hematopoietic stem cells in the murine bone marrow.
• An Update from the United States National Heart, Lung, and Blood Institute-funded Production Assistance for Cellular Therapies (PACT) Program: A Decade of Cell Therapy.
• Aberrant expression of SALL4 in acute B cell lymphoblastic leukemia: Mechanism, function, and implication for a potential novel therapeutic target.
• A new image of the hematopoietic stem cell vascular niche.
• Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.
• Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance.
• Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment.
• In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.
• Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells.
• Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments.
• Cardiomyocyte proliferation contributes to heart growth in young humans.
• Fak Depletion in Both Hematopoietic and Non-hematopoietic Niche cells Leads to Hematopoietic Stem Cell Expansion.
• Pre-treatment with PTEN inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model.
• Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.
• VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor.
• Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs.
• Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals.
• Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation.
• FAK silencing inhibits leukemogenesis in BCR/ABL-transformed hematopoietic cells.
• IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice.
• Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis.
• SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis.
• Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells.
• In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration.
• Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors.
• Complement C3a enhances CXCL12 (SDF-1)-mediated chemotaxis of bone marrow hematopoietic cells independently of C3a receptor.
• CXC chemokine ligand 12-induced focal adhesion kinase activation and segregation into membrane domains is modulated by regulator of G protein signaling 1 in pro-B cells.
• Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells.
• Sustained activation of cell adhesion is a differentially regulated process in B lymphopoiesis.
• CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokin...

Doctors Specialties

---

• Blood Banking
• Hematology
• Pathology

Accepted Insurances

---

Awards

---

• Elected Member

Education

---

• Tufts Medical Center
• Leiden University Faculty of Medicine

Hospital

---

• Boston Children's Hospital
• Brigham and Women's Hospital

Helpful Reviews

---

Give Anonymous Review

Similar Doctors

---

	Dr. Allan Kliman, MD This Doctor is OpenDoctor Recommended.
	Dr. Christopher P. Stowell, MD This Doctor is OpenDoctor Recommended.
	Dr. Katayoon Goodarzi, MD This Doctor is OpenDoctor Recommended.
	Dr. Walter H. Dzik, MD This Doctor is OpenDoctor Recommended. This doctor has more publications
	Dr. Benjamin L. Schlechter, MD This Doctor is OpenDoctor Recommended.
	Dr. Meghan J. Campo, MD This Doctor is OpenDoctor Recommended.
	Dr. Srinivas R. Viswanathan, MD This Doctor is OpenDoctor Recommended.
	Dr. Gerburg M. Wulf, MD This Doctor is OpenDoctor Recommended. This doctor has more publications
	Dr. Winthrop H. Churchill Jr., MD This Doctor is OpenDoctor Recommended.
	Dr. Amy H. Comander, MD This Doctor is OpenDoctor Recommended.
	Dr. Saulius Girnius, MD This Doctor is OpenDoctor Recommended.
	Dr. Stephen P. Naber, MD This Doctor is OpenDoctor Recommended. This doctor has more publications
	Dr. Elizabeth M. Genega, MD This Doctor is OpenDoctor Recommended. This doctor has more publications
	Dr. Kimberley M. Springer, MD This Doctor is OpenDoctor Recommended.
	Dr. Kimberly S. Esham, MD This Doctor is OpenDoctor Recommended.
	Dr. Manisha N. Mehta, MD This Doctor is OpenDoctor Recommended.

---

Doctor Directory | TOS | twitter | FB | Angel | blog