Professor of Pediatrics and Neurology, Feinberg School of Medicine, Northwestern University
Neurology
Dr. Leon G. Epstein, MD
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Dr. Leon G. Epstein works in the field of Neurology. He researched medicine at Wayne State University School of Medicine. Wayne State University School of Medicine is ranked 63 in research and 85 in primary care medicine He over the years received 13 awards: "America's Top Doctors", "Chicago Magazine: Top Doctors", "Distinguished Alumnus", "Fellow", "Derry A. and Donald L. Shoemaker Professor of Pediatric Neurology", "Arthur Kornberg Research Award", "Fulbright Scholar", "Weinstein-Goldenson Research Award", "Teaching Award, Morning Report", "Elected Active Member", "Exceptional Merit Award for Excellence in Teaching", "Exceptional Merit Award for Excellence in Teaching and Research" and "Super Doctor". Leon Epstein has written publications. He has 100 publications published with PubMed. The lastest publication is: 'Luciferase: a sensitive and quantitative probe for blood-brain barrier disruption.'
Publications
- Detection of HTLV-III RNA in lungs of patients with AIDS and pulmonary involvement.
- Human herpesvirus-6 infection in children. A prospective study of complications and reactivation.
- HTLV-III infection in brains of children and adults with AIDS encephalopathy.
- Hippocampal Sclerosis After Febrile Status Epilepticus: The FEBSTAT Study.
- Human herpesvirus 6 and 7 in febrile status epilepticus: the FEBSTAT study.
- Infantile colic and Migraine.
- Phenomenology of prolonged febrile seizures: results of the FEBSTAT study.
- Persistence of human herpesvirus 6 according to site and variant: possible greater neurotropism of variant A.
- A comparative evaluation of quantitative neuroimaging measurements of brain status in HIV infection.
- Brain alterations within the first 100 days of HIV infection.
- Clinical impact of primary infection with roseoloviruses.
- No PEDs in Pediatrics.
- Obituary for M. Richard Koenigsberger, MD.
- Matrix metalloproteinase levels in early HIV infection and relation to in vivo brain status.
- Risk Factors for Febrile Status Epilepticus: A Case-Control Study.
- Obituary: m. Richard koenigsberger: lifetime contributions to child neurology.
- Pediatric neuroenhancement: ethical, legal, social, and neurodevelopmental implications.
- Structural brain alterations can be detected early in HIV infection.
- Cerebrospinal Fluid Findings in Children with Fever-Associated Status Epilepticus: Results of the Consequences of Prolonged Febrile Seizures (FEBSTAT) Study.
- Design and phenomenology of the FEBSTAT study.
- Tracking the impact of the National Institutes of Health Clinical and Translational Science Awards on child health research: developing and evaluating a measurement s...
- Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection.
- Biomarkers of neurological status in HIV infection: a 3-year study.
- Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection.
- Emerging subspecialties in neurology: neuroinfectious diseases.
- Rolandic mitochondrial encephalomyelopathy and MT-ND3 mutations.
- Whole brain and localized magnetization transfer measurements are associated with cognitive impairment in patients infected with human immunodeficiency virus.
- Biomarkers of HIV-1 CNS infection and injury.
- Updated research nosology for HIV-associated neurocognitive Disorders.
- Platelet decline: an avenue for investigation into the pathogenesis of human immunodeficiency virus -associated dementia.
- An evaluation of neurocognitive status and markers of immune activation as predictors of time to death in advanced HIV infection.
- Cyclophosphamide treatment of primary angiitis of the central nervous system in children: report of 2 cases.
- A transdisciplinary approach to improve health literacy and reduce disparities.
- Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection.
- Diffusion alterations in corpus callosum of patients with HIV.
- Diffusion tensor imaging of subcortical brain injury in patients infected with human immunodeficiency virus.
- Markers of immune activation and viral load in HIV-associated sensory neuropathy.
- Disease burden in HIV-associated cognitive impairment: a study of whole-brain imaging measures.
- Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia.
- Attenuated central nervous system infection in advanced HIV/AIDS with combination antiretroviral therapy.
- Whole brain diffusion tensor imaging in HIV-associated cognitive impairment.
- Inter-rater reliability of a clinical staging of HIV-associated cognitive impairment.
- Release of the neuronal glycoprotein ICAM-5 in serum after hypoxic-ischemic injury.
- Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system.
- Expression of caspase-3 in brains from paediatric patients with HIV-1 encephalitis.
- Association of human herpesvirus 6 with the demyelinative lesions of progressive multifocal leukoencephalopathy.
- Randomized trial of the platelet-activating factor antagonist lexipafant in HIV-associated cognitive impairment. Neurological AIDS Research Consortium.
- Coreceptor ligand inhibition of fetal brain cell infection by HIV type 1.
- Proteasome blockers inhibit TNF-alpha release by lipopolysaccharide stimulated macrophages and microglia: implications for HIV-1 dementia.
- HIV-1-induced neuronal injury in the developing brain.
- Luciferase: a sensitive and quantitative probe for blood-brain barrier disruption.
- HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism.
- Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis.
- Neurologic manifestations of infection with HIV.
- HIV neuropathogenesis and therapeutic strategies.
- X-linked female band heterotopia-male lissencephaly Syndrome.
- Does human herpesvirus 8 have a pathogenetic role in primary CNS lymphoma?
- Risk of recurrent seizures after a primary human herpesvirus 6-induced febrile seizure.
- Neurological manifestations of perinatally acquired HIV-1 infection.
- Expression of pro- and anti-apoptosis gene products in brains from paediatric patients with HIV-1 encephalitis.
- Human fetal astrocytes as an ex vivo gene therapy vehicle for delivering biologically active nerve growth factor.
- The development of animal model systems for HIV-1 encephalitis and its associated dementia.
- Cellular localization of human herpesvirus-6 in the brains of children with AIDS encephalopathy.
- Simultaneous in situ detection of apoptosis and necrosis in monolayer cultures by TUNEL and trypan blue staining.
- In situ trypan blue staining of monolayer cell cultures for permanent fixation and mounting.
- Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures.
- Familial autosomal-dominant carpal tunnel Syndrome presenting in a 5-year-old-case report and review of the literature.
- Bovine spongiform encephalopathy and a new variant of Creutzfeldt-Jakob disease.
- HIV-1 encephalopathy in children.
- Activation of nuclear factor kappa B in brains from children with HIV-1 encephalitis.
- Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia.
- In situ amplification and detection of HIV-1 DNA in fixed pediatric AIDS brain tissue.
- Degenerative central nervous system disease.
- Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy.
- Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA.
- Prenatal diagnosis of moderate unilateral Hydrocephalus subsequently not requiring neonatal decompression.
- Detection of HIV-1 DNA in pediatric AIDS brain tissue by two-step ISPCR.
- Human neural xenografts: progress in developing an in-vivo model to study human immunodeficiency virus (HIV) and human cytomegalovirus (HCMV) infection.
- Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications fo...
- Neuroinvasion and persistence of human herpesvirus 6 in children.
- Interaction of HIV-1 and human salivary mucins.
- HIV-1 infection of the developing nervous system: central role of astrocytes in pathogenesis.
- Cytomegalovirus infection of human retinal tissue: an in vivo model.
- Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues.
- Aggregation of human immunodeficiency virus type 1 by human salivary secretions.
- Human immunodeficiency virus type 1 infection of the nervous system: pathogenetic mechanisms.
- Excitotoxicity and dopaminergic dysfunction in the acquired immunodeficiency Syndrome dementia complex. Therapeutic implications.
- Successful xenografts of second trimester human fetal brain and retinal tissue in the anterior chamber of the eye of adult immunosuppressed rats.
- Idiopathic childhood stroke is associated with human leukocyte antigen (HLA)-B51.
- Human immunodeficiency virus type 1 nef quasispecies in pathological tissue.
- Neurologic manifestations of pediatric acquired immunodeficiency Syndrome: clinical features and therapeutic approaches.
- Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo.
- HIV-1 V3 domain variation in brain and spleen of children with AIDS: tissue-specific evolution within host-determined quasispecies.
- Spinal cord disease in children with HIV-1 infection: a combined molecular biological and neuropathological study.
- Human immunodeficiency virus type 1 (HIV-1) infection of the nervous system: a review.
- Lentiviral encephalitides in the immature host: a comparison of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) brain infection.
- Antibody response to human immunodeficiency virus type 1 protease according to risk group and disease stage.
- Elevated serum levels of tumor necrosis factor are associated with progressive encephalopathy in children with acquired immunodeficiency Syndrome.
- Delayed traumatic intracerebral hemorrhage in children.
Schools
Wayne State University
Ny and Presby Hp Columbia Campus
St Joseph Mercy Health Sys
University Med Center
Conditions Treated
- Ataxia
- Bell's Palsy
- Concussion
- Convulsions
- View All
Doctors Specialties
- Pediatric Neurology
- Neurology
Accepted Insurances
- Aetna
- Blue Card PPO
- Blue Cross Blue Shield of Illinois PPO
- Group Employees PPO
- Blue Cross Accord
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Open Access Plus
- CoreSource
- Coventry Health Care
- Coventry Health Care of Illinois PPO
- Health and Life PPO
- Platinum PPO
- Coventry Health Care of Missouri PPO
- First Health (Coventry Health Care) PPO
- Golden Rule
- HealthLink PPO
- Choice Care PPO
- Preferred PPO
- Medicare MCR
- Meritain Health
- MultiPlan PPO
- PHCS Network PPO
- Sagamore Plus
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Awards
- America's Top Doctors
- Chicago Magazine: Top Doctors
- Distinguished Alumnus
- Fellow
- Derry A. and Donald L. Shoemaker Professor of Pediatric Neurology
- Arthur Kornberg Research Award
- Fulbright Scholar
- Weinstein-Goldenson Research Award
- Teaching Award, Morning Report
- Elected Active Member
- Exceptional Merit Award for Excellence in Teaching
- Exceptional Merit Award for Excellence in Teaching and Research
- Super Doctor
Education
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New York Presbyterian Hospital - Columbia Campus -
University of Arizona -
St Joseph Mercy Livingston Hospital -
Wayne State University School of Medicine -
University of Michigan
Hospital
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Ann & Robert H. Lurie Children? -
Lurie Children's Hospital of Chicago -
Northwestern Memorial Hospital
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