Ensign Professor of Medicine Yale School of Medicine
Endocrinology
Dr. Karl L. Insogna, MD
|
|
Give Review
Karl Insogna is an expert in the field of Endocrinology. He attended University of Connecticut School of Medicine. University of Connecticut School of Medicine has a rank of 60 in research and a 49 in primary care He has 2 awards "CMS Meaningful Use Stage 1 Certification" and "Elected Member". Karl Insogna has written publications. He has 101 publications published with PubMed. The lastest paper is: 'The role of parathyroid hormone in the pathogenesis, prevention and treatment of postmenopausal osteoporosis.' Karl Insogna accepts Medicare payments and is listed with Medicare.gov.
Publications
- Pharmacokinetics and pharmacodynamics of a human monoclonal anti-FGF23 antibody (KRN23) in the first multiple ascending dose trial treating adults with X-linked hypop...
- Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age-Dependent Change in Osteoclast Number and a Reduced Number of Osteoblasts In Vivo.
- Effect of 25(OH) Vitamin D reference method procedure (RMP) alignment on clinical measurements obtained with the IDS-iSYS chemiluminescent-based automated analyzer.
- Effect of Paricalcitol on Circulating ParaThyroid Hormone in X-linked Hypophosphatemia: A Randomized, Double-blind, Placebo-controlled Study.
- Serum levels of sclerostin, Dickkopf-1, and secreted frizzled-related protein-4 are not changed in individuals with high bone mass causing mutations in LRP5.
- Measurement of Plasma, Serum, and Platelet Serotonin in Individuals With High Bone Mass and Mutations in LRP5.
- An investigation of the association between omega 3 FA and bone mineral density among older adults: results from the National Health and Nutrition Examination Survey y...
- Dietary acid load is associated with lower bone mineral density in men with low intake of dietary Calcium.
- Dietary protein-induced increases in urinary Calcium are accompanied by similar increases in urinary nitrogen and urinary urea: a controlled clinical trial.
- Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats.
- Claudins, dietary milk proteins, and intestinal barrier regulation.
- LIM kinase 1 deficient mice have reduced bone mass.
- A clinician's guide to X-linked hypophosphatemia.
- Calcium intake in the United States from dietary and supplemental sources across adult age groups: new estimates from the National Health and Nutrition Examination Sur...
- Calcitonin administration in X-linked hypophosphatemia.
- Control of bone formation by the serpentine receptor Frizzled-9.
- Circulating levels of soluble klotho and FGF23 in X-linked hypophosphatemia: circadian variance, effects of treatment, and relationship to paraThyroid status.
- Inhibiting gastric acid production does not affect intestinal Calcium absorption in young, healthy individuals: a randomized, crossover, controlled clinical trial.
- Optimizing bone health in older adults: the importance of dietary protein.
- The effect of dietary protein on intestinal Calcium absorption in rats.
- Survey of the enthesopathy of X-linked hypophosphatemia and its characterization in Hyp mice.
- Increasing dietary protein requirements in elderly people for optimal muscle and bone health.
- The effect of proton pump-inhibiting drugs on mineral Metabolism.
- Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone.
- Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum.
- Orthopaedic management improves the rate of early Osteoporosis treatment after hip fracture. A randomized clinical trial.
- The role of the receptor activator of nuclear factor-kappaB ligand/osteoprotegerin cytokine system in primary Hyperparathyroidism.
- Proton pump-inhibiting drugs, Calcium homeostasis, and bone health.
- Colony-stimulating factor-1 increases osteoclast intracellular pH and promotes survival via the electroneutral Na/HCO3 cotransporter NBCn1.
- Meat and soy protein affect Calcium homeostasis in healthy women.
- Isotretinoin does have an adverse effect on bone mineral density.
- Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors.
- The impact of dietary protein on Calcium absorption and kinetic measures of bone turnover in women.
- The expanding role of PI3-kinase in bone.
- Dietary protein, Calcium metabolism, and skeletal homeostasis revisited.
- Low protein intake: the impact on Calcium and bone homeostasis in humans.
- Overexpression of parathyroid hormone-related protein causes Hypercalcemia but not bone metastases in a murine model of mammary tumorigenesis.
- Evidence that the IL-6/IL-6 soluble receptor cytokine system plays a role in the increased skeletal sensitivity to PTH in estrogen-deficient women.
- Adequate Dietary Protein is Associated with Better Physical Performance among Post-Menopausal Women 60-90 Years.
- High bone density due to a mutation in LDL-receptor-related protein 5.
- A role for cell-surface CSF-1 in osteoblast-mediated osteoclastogenesis.
- IL-6 negatively regulates IL-11 production in vitro and in vivo.
- Parameters of high bone-turnover predict bone loss in renal transplant patients: a longitudinal study.
- Dietary protein and intestinal Calcium absorption.
- ParaThyroid hormone induces hepatic production of bioactive interleukin-6 and its soluble receptor.
- Posttransplant bone Disease: evidence for a high bone resorption state.
- Nuclear factor-kappaB p50 is required for tumor necrosis factor-alpha-induced colony-stimulating factor-1 gene expression in osteoblasts.
- Estrogen modulates paraThyroid hormone-induced interleukin-6 production in vivo and in vitro.
- A threshold for low-protein-diet-induced elevations in paraThyroid hormone.
- Evidence for a functional association between phosphatidylinositol 3-kinase and c-src in the spreading response of osteoclasts to colony-stimulating factor-1.
- ParaThyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade.
- Low dietary protein and low bone density.
- A role for interleukin-6 in paraThyroid hormone-induced bone resorption in vivo.
- Bone densities in patients receiving isotretinoin for cystic acne.
- Changes in bone turnover in young women consuming different levels of dietary protein.
- The role of parathyroid hormone in the pathogenesis, prevention and treatment of postmenopausal Osteoporosis.
- Dietary protein affects intestinal Calcium absorption.
- The cell-surface form of colony-stimulating factor-1 is regulated by osteotropic agents and supports formation of multinucleated osteoclast-like cells.
- Colony-stimulating factor-1 induces cytoskeletal reorganization and c-src-dependent tyrosine phosphorylation of selected cellular proteins in rodent osteoclasts.
- Increased circulating concentrations of paraThyroid hormone in healthy, young women consuming a protein-restricted diet.
- ParaThyroid hormone increases circulating levels of fibronectin in vivo: modulating effect of ovariectomy.
- The effects of dairy products on body composition, bone mineralization, and weight in adolescent girls (Nutr Rev 1996;54:64-65)
- Role of c-Src in cellular events associated with colony-stimulating factor-1-induced spreading in osteoclasts.
- 24,25 Dihydroxyvitamin D supplementation corrects Hyperparathyroidism and improves skeletal abnormalities in X-linked hypophosphatemic rickets--a clinical research cen...
- Boning up on estrogen: new options, new concerns.
- Colony stimulating factor-1 plays a role in osteoclast formation and function in bone resorption induced by paraThyroid hormone and paraThyroid hormone-related protein.
- Circulating levels of interleukin-6 and tumor necrosis factor-alpha are elevated in primary Hyperparathyroidism and correlate with markers of bone resorption--a clinic...
- Effects of continuous glucocorticoid infusion on bone Metabolism in the rat.
- Tumor necrosis factor-alpha induces transcription of the colony-stimulating factor-1 gene in murine osteoblasts.
- Human granulosa-luteal cells secrete paraThyroid hormone-related protein in vivo and in vitro.
- Secondary Hyperparathyroidism in patients with ichthyosis is not caused by vitamin D deficiency or ingestion of retinoids.
- Calcium and kidney stones.
- Macrophage colony-stimulating factor release and receptor expression in bone cells.
- Nocturnal Hyperparathyroidism: a frequent feature of X-linked hypophosphatemia.
- Dietary hypercalciuria in patients with Calcium oxalate kidney stones.
- ParaThyroid hormone-related protein: evidence for isoform- and tissue-specific posttranslational processing.
- Estrogen modulates paraThyroid hormone-induced fibronectin production in human and rat osteoblast-like cells.
- Osteoporosis and aging: the continuing crisis.
- Osteomalacia and weakness from excessive antacid ingestion.
- Evidence for bidirectional net movement of creatinine in the rat kidney.
- Factors associated with humoral Hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
- Biochemical and histomorphometric characterization of a rat model for humoral Hypercalcemia of malignancy.
- A consideration of the hormonal basis and phosphate leak hypothesis of absorptive hypercalciuria.
- Vitamin D Metabolism and bone histomorphometry in a patient with antacid-induced osteomalacia.
- Hypercalciuria as a metabolic Disease.
- Evidence for disordered control of 1,25-dihydroxyVitamin D production in absorptive hypercalciuria.
- Impaired Phosphorus conservation and 1,25 dihydroxyvitamin D generation during Phosphorus deprivation in familial hypophosphatemic rickets.
- Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients wi...
- Influence of pregnancy on immunoreactive paraThyroid hormone levels.
- Effect of age on serum immunoreactive paraThyroid hormone and its biological effects.
- Elevations in circulating 1,25-dihydroxyvitamin D in three patients with lymphoma-associated Hypercalcemia.
- Primary Hyperparathyroidism in a dog: biochemical, bone histomorphometric, and pathologic findings.
- Concerning the pathogenesis of idiopathic hypercalciuria.
- Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral Hypercalcemia of malignancy.
- Hypercalcemia of malignancy.
- Co-purification of transforming growth factor beta-like activity with PTH-like and bone-resorbing activities from a tumor associated with humoral Hypercalcemia of mali...
- The relative potency of a human tumor-derived PTH-like adenylate cyclase-stimulating preparation in three bioassays.
- Influence of furosemide on parathyroid hormone levels in Hyperparathyroidism.
- In vitro adenylate cyclase-stimulating activity predicts the occurrence of humoral Hypercalcemia of malignancy in nude mice.
- Synthetic human parathyroid hormone-like protein stimulates bone resorption and causes Hypercalcemia in rats.
Schools
Univ Of Ct Sch Of Med
Strong Mem Hsp University Rochester
Yale New Haven Hospital
Conditions Treated
- Adrenal Insufficiency
- Calcium Metabolism Disorders
- Diabetes Type 2
- Goiter
- View All
Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Elected Member
Education
-
Yale-New Haven Hospital -
University of Rochester -
University of Connecticut School of Medicine
Hospital
-
Yale-New Haven Hospital
Drug Facts
| NPI NUMBER | 1346223559 | |
| NPPES Provider LastName | INSOGNA | |
| NPPES Provider FirstName | KARL | |
| NPPES Provider ZIPCode | 065191304 | |
| NPPES Provider State | CT | |
| Specialty Description | Endocrinology | |
| Total Claim Count | 156.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1346223559 |
| Last Name Of The Provider | INSOGNA |
| First Name Of The Provider | KARL |
| View All |
Similar Doctors
|
|
Dr. Olga V. Sakharova, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Anne W. Camp, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Surani R. Fernando, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Norman J. Marieb, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Gerald I. Shulman, MD
This Doctor is OpenDoctor Recommended.
|