Physician
Endocrinology
Dr. Gerald I. Shulman, MD
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Gerald Shulman works in the field of Endocrinology. He graduated from Wayne State University School of Medicine. Wayne State University School of Medicine is ranked 63 in research and 85 in primary care medicine He over the years received 3 awards: "Elected Member", "Investigator" and "Whos Who in Medicine and Healthcare". Doctor Gerald I. Shulman, MD has written publications. He has 100 publications published with PubMed. The lastest paper is: 'Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice.'
Publications
- A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents.
- Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice.
- AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia.
- Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats.
- ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content.
- Response to burgess.
- Reply to Constantin-Teodosiu et al.: Mice with genetic PDH activation are not protected from high-fat diet-induced muscle insulin resistance.
- Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation.
- Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.
- Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.
- Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II.
- Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance.
- The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells.
- An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ
- Hepatic MAP kinase phosphatase-1 Selectively Regulates Glucose Metabolism and Energy Homeostasis.
- Mitochondrial GTP insensitivity contributes to hypoglycemia in Hyperinsulinemia Hyperammonemia (HI/HA) by inhibiting glucagon release.
- The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes.
- Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis.
- Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.
- PKCλ haplo-insufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.
- Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.
- Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile non-human primates.
- Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice.
- Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity.
- Ceramide-Activated Phosphatase Mediates Fatty Acid-Induced Endothelial VEGF Resistance and Impaired Angiogenesis.
- Regulation of Hepatic Energy Metabolism and Gluconeogenesis by BAD.
- Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposit...
- Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic (13)C magnetic resonance spectroscopy.
- Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.
- Reversal of hypertriglyceridemia, Fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler.
- A β-Peptide Agonist of the GLP-1 Receptor, a Class B GPCR.
- PP2A inhibition results in hepatic insulin resistance despite Akt2 activation.
- Increased brain lactate concentrations without increased lactate oxidation during hypoglycemia in type 1 diabetic individuals.
- Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice.
- Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance.
- Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo.
- Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways.
- Fish Oil Selectively Improves Heart Function in a Mouse Model of Lipid-induced Cardiomyopathy.
- Role of caspase-1 in regulation of triglyceride metabolism.
- CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance.
- Cellular Mechanism by Which Estradiol Protects Female Ovariectomized Mice from High-Fat Diet-Induced Hepatic and Muscle Insulin Resistance.
- The role of the carbohydrate response element-binding protein in male fructose-fed rats.
- The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
- Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats.
- Skeletal Muscle Insulin Resistance Promotes Increased Hepatic De Novo Lipogenesis, Hyperlipidemia, and Hepatic Steatosis in the Elderly.
- Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial en...
- Thyroid Hormone Receptor-? Gene Knockout Mice Are Protected from Diet-Induced Hepatic Insulin Resistance.
- SirT1 Regulates Adipose Tissue Inflammation.
- Dissociation of inositol requiring enzyme (IRE1?)-mediated JNK activation from hepatic insulin resistance in conditional X-box binding protein-1 (XBP1) knockout mice.
- Dissociation of the Glucose and Lipid Regulatory Functions of FoxO1 by Targeted Knockin of Acetylation-Defective Alleles in Mice.
- Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease.
- Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.
- Hyperglucagonemia Precedes a Decline in Insulin Secretion and Causes Hyperglycemia in Chronically Glucose-Infused Rats.
- Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals.
- Influence of the hepatic eIF2{alpha} ER stress response pathway on insulin mediated ER stress, Hepatic and Peripheral Glucose Metabolism.
- Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice.
- Indy knockdown in mice mimics elements of dietary restriction.
- Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance.
- GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function.
- Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype.
- Magnetic resonance spectroscopy studies of human metabolism.
- Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2.
- Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance.
- Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance.
- FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.
- Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues.
- SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function.
- Characterization of the hyperphagic response to dietary fat in the MC4R knockout mouse.
- Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy.
- Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.
- A guide to analysis of mouse energy metabolism.
- Lysophosphatidic Acid Activates Peroxisome Proliferator Activated Receptor-γ in CHO Cells That Over-Express Glycerol 3-Phosphate Acyltransferase-1.
- Impact of CD1d deficiency on metabolism.
- Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptake.
- Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.
- A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain.
- CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance.
- Sirtuin-1 regulation of mammalian metabolism.
- The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy.
- Downregulation of ADIPOQ and PPARγ2 gene expression in subcutaneous adipose tissue of obese adolescents with hepatic steatosis.
- PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation.
- A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents.
- Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese adolescents: association with insulin resistance and hepatic steatosis.
- The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome.
- Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity.
- Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity.
- Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency.
- Uncoupling protein-2 decreases the lipogenic actions of ghrelin.
- Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake.
- Effects of pioglitazone on intramyocellular fat metabolism in patients with type 2 diabetes mellitus.
- Diacylglycerol-mediated insulin resistance.
- Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia.
- Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease.
- Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy.
- PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis.
- MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice.
- Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein.
- Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1.
- Akt2 is required for hepatic lipid accumulation in models of insulin resistance.
Schools
Wayne State University
Duke University
Mass Genl HospHarvard
Doctors Specialties
- Endocrinology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Pathway X Ind PPO Direct Access CT
- Blue Card PPO
- Cigna HMO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Connecticare HMO
- Connecticare POS
- Medicaid
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Freedom Plan
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- Oxford Liberty
Awards
- Elected Member
- Investigator
- Whos Who in Medicine and Healthcare
Education
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Massachusetts General Hospital -
Duke University Hospital -
Wayne State University School of Medicine
Hospital
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Yale-New Haven Hospital
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