Professor of Pathology, Brigham and Women's Hospital
Pathology
Dr. Jon C. Aster, MD
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Aster is an expert in the field of Pathology. He graduated from University of Michigan Medical School. Aster has written publications. He has 101 publications published with PubMed. The lastest paper is: 'Metabolic Mechanisms of Drug Resistance in Leukemia.' Aster accepts Medicare.
Publications
- Metabolic Mechanisms of Drug Resistance in Leukemia.
- Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure.
- Cyclin C is a haploinsufficient tumour suppressor.
- The Role of Notch Receptors in Transcriptional Regulation.
- Discovery of Biomarkers Predictive of GSI Response in Triple-Negative Breast Cancer and Adenoid Cystic Carcinoma.
- Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.
- Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.
- The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.
- An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
- SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia.
- NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.
- In Brief: Notch Signaling in Health and Disease.
- Intrinsic Selectivity of Notch 1 for Delta-like 4 Over Delta-like 1.
- MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma.
- Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer.
- Resistance revealed in acute lymphoblastic leukemia.
- Modulation of gene expression via overlapping binding sites exerted by ZNF143, Notch1 and THAP11.
- Divergent effects of supraphysiological Notch signals on leukemia stem cells and hematopoietic stem cells.
- Differential roles of Kras and Pten in murine leukemogenesis.
- T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.
- Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.
- High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.
- Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth.
- Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells.
- Temporal Dissection of Tumorigenesis in Primary Cancers.
- Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.
- Crosstalk between Notch and AKT signaling during murine megakaryocyte lineage specification.
- Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.
- Evidence for Increased Exposure of the Notch1 Metalloprotease Cleavage Site upon Conversion to an Activated Conformation.
- Differentiation of NUT midline carcinoma by epigenomic reprogramming.
- Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.
- Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.
- Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.
- An asymptomatic 61-year-old man with BCR-ABL-positive bone marrow following autologous transplantation for multiple myeloma.
- A prospective study of Epstein-Barr virus antibodies and risk of non-Hodgkin lymphoma.
- Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.
- Notch dimerization is required for leukemogenesis and T-cell development.
- Plasma organochlorine levels and risk of non-Hodgkin lymphoma in the Nurses' Health Study.
- Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.
- Plasma organochlorine levels and risk of non-Hodgkin lymphoma in a cohort of men.
- When to go FISHing.
- A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.
- Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.
- Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.
- Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody.
- Notch targeting 2.0.
- Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.
- Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models.
- Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases.
- Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.
- Novel SSBP2-JAK2 fusion gene resulting from a t(5;9)(q14.1;p24.1) in pre-B acute lymphocytic leukemia.
- Notch signaling specifies megakaryocyte development from hematopoietic stem cells.
- Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.
- NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract.
- Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells.
- Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3.
- Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1.
- Notch signaling in leukemia.
- Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia.
- Delta-like 4 induces notch signaling in macrophages: implications for inflammation.
- Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma.
- Structural basis for autoinhibition of Notch.
- Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription.
- Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice.
- A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.
- NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.
- Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.
- EBNA-3B- and EBNA-3C-regulated cellular genes in Epstein-Barr virus-immortalized lymphoblastoid cell lines.
- c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
- Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.
- Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes.
- FAS death domain deletions and cellular FADD-like interleukin 1beta converting enzyme inhibitory protein (long) overexpression: alternative mechanisms for deregulating...
- Infection and persistence of rhesus monkey rhadinovirus in immortalized B-cell lines.
- Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
- Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma.
- Activating Notch1 mutations in mouse models of T-ALL.
- Lack of IKBA coding region mutations in primary mediastinal large B-cell lymphoma and the host response subtype of diffuse large B-cell lymphoma.
- Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies.
- Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities.
- Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population.
- A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.
- NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes.
- Notch signaling controls the generation and differentiation of early T lineage progenitors.
- Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response.
- TRAF1 expression and c-Rel activation are useful adjuncts in distinguishing classical Hodgkin lymphoma from a subset of morphologically or immunophenotypically similar...
- T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling.
- Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats.
- Midline carcinoma of children and young adults with NUT rearrangement.
- Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
- JAGGED1 expression is associated with prostate cancer metastasis and recurrence.
- Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.
- Experimental rhesus lymphocryptovirus infection in immunosuppressed macaques: an animal model for Epstein-Barr virus pathogenesis in the immunosuppressed host.
- Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.
- Functional diversity of notch family genes in fetal lung development.
- Molecular evidence for rhesus lymphocryptovirus infection of epithelial cells in immunosuppressed rhesus macaques.
- Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib.
- No T without D3: a critical role for cyclin D3 in normal and malignant precursor T cells.
- The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymph...
- F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation.
- Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1.
Schools
University of Mi Med Sch
Brigham and Women39s Hospital
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Education
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Brigham and Women's Hospital -
University of Michigan Medical School
Hospital
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Brigham and Women's Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1023075702 |
| Last Name Of The Provider | ASTER |
| First Name Of The Provider | JON |
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