Professor of Pathology, Beth Israel Deaconess Medical Center

Pathology

Ann M. Dvorak works in the field of Pathology. She researched medicine at University of Vermont College of Medicine. Ann M. Dvorak, MD is also a published physician. She has 47 publication published. The most recent publication is: CD63 is tightly associated with intracellular, secretory events chaperoning piecemeal degranulation and compound exocytosis in human eosinophils.

Publications

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• Pre-embedding immunogold labeling to optimize protein localization at subcellular compartments and membrane microdomains of leukocytes.
• Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance.
• TM4SF1: a new vascular therapeutic target in cancer.
• The Tetraspanin CD63 Is Required for Efficient IgE-Mediated Mast Cell Degranulation and Anaphylaxis.
• Evolutionary origins of the blood vascular system and endothelium.
• Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds.
• Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion competent eosinophil granules.
• Mesenchymal Stem Cells Transmigrate Between and Directly Through Tumor Necrosis Factor-α-Activated Endothelial Cells Via Both Leukocyte-Like and Novel Mechanisms.
• TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration.
• Lipid bodies in inflammatory cells: structure, function, and current imaging techniques.
• Contributions of electron microscopy to understand secretion of immune mediators by human eosinophils.
• Heterogeneity of the tumor vasculature.
• Vascular permeability and pathological angiogenesis in caveolin-1-null mice.
• Vesicle-mediated secretion of human eosinophil granule-derived major basic protein.
• Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation.
• Eosinophil granules function extracellularly as receptor-mediated secretory organelles.
• Mechanisms of eosinophil secretion: large vesiculotubular carriers mediate transport and release of granule-derived cytokines and other proteins.
• Chapter 3. The adenoviral vector angiogenesis/lymphangiogenesis assay.
• SNAP-23 and syntaxin-2 localize to the extracellular surface of the platelet plasma membrane.
• Vascular bed-specific endothelium-dependent vasomomotor relaxation in the hagfish, Myxine glutinosa.
• Transcellular diapedesis is initiated by invasive podosomes.
• X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation.
• Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium.
• VEGF-A and the induction of pathological angiogenesis.
• Roles and origins of leukocyte lipid bodies: proteomic and ultrastructural studies.
• Permeability properties of tumor surrogate blood vessels induced by VEGF-A.
• Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.
• Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion.
• Ultrastructural studies of human basophils and mast cells.
• ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow.
• Loss of histochemical identity in mast cells lacking carboxypeptidase A.
• The actin cytoskeleton differentially regulates platelet alpha-granule and dense-granule secretion.
• Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin.
• Microvascular patterning is controlled by fine-tuning the Akt signal.
• Pathologic quiz case. A symptomatic renal tumor. Juxtaglomerular cell tumor.
• Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite.
• Ultrastructural localization of platelet endothelial cell adhesion molecule (PECAM-1, CD31) in vascular endothelium.
• Neuroendocrine cell secretory granules are not bacteria in inflammatory bowel disease.
• VEGF-A(164/165) and PlGF: roles in angiogenesis and arteriogenesis.
• Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis.
• Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins.
• Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumor-associated mic...
• Subcellular distribution of 3 functional platelet SNARE proteins: human cellubrevin, SNAP-23, and syntaxin 2.
• The internal architecture of leukocyte lipid body organelles captured by three-dimensional electron microscopy tomography.
• Lipid body-phagosome interaction in macrophages during infectious diseases: host defense or pathogen survival strategy?
• CD63 is tightly associated with intracellular, secretory events chaperoning piecemeal degranulation and compound exocytosis in human eosinophils.

Schools

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• University of Vermont College of Medicine

• Boston Floating Hospital Ma

• Children39s Hospital Of Dc

• Georgetown University School Of Med

• Peter Bent Brigham Hospital

• Harvard Med School

Doctors Specialties

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• Anatomic Pathology
• Pediatrics
• Pathology

Accepted Insurances

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Education

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• Brigham and Women's Hospital
• Georgetown University Hospital
• Children's National Medical Center - George Washington University
• University of Vermont College of Medicine

Hospital

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• Beth Israel Deaconess Medical Center

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