Assistant Clinical Professor of Medicine, Massachusetts General Hospital
Allergy & Immunology
Dr. James A. MacLean, MD
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James MacLean works in the field of Allergy & Immunology. He received 7 awards: "America's Top Doctors", "CMS Meaningful Use Stage 1 Certification", "Boston Magazine", "Boston Herald", "Fellow (FAAAAI)", "Super Doctor" and "Top MD". James MacLean is also published. He has 52 publications published. The lastest publication: "Indirect T cell allorecognition and alloantibody-mediated rejection of MHC class I-disparate heart grafts.' He accepts Medicare.
Publications
- Loss of Cdh1 and Trp53 in the uterus induces Chronic inflammation with modification of tumor microenvironment.
- The RHOX Homeodomain Proteins Regulate the Expression of Insulin and Other Metabolic Regulators in the Testis.
- The role of Rhox homeobox factors in tumorigenesis.
- WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/?-catenin pathway.
- The rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone h1 and DNA methylation.
- WNTs in the neonatal mouse uterus: potential regulation of endometrial gland development.
- Wnt genes in the mouse uterus: potential regulation of implantation.
- The RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5c.
- Regulation and function of the Rhox5 homeobox gene.
- Rhox homeobox gene cluster: recent duplication of three family members.
- Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis.
- Regulation of the Rhox5 homeobox gene in primary granulosa cells: preovulatory expression and dependence on SP1/SP3 and GABP.
- Rhox: a new homeobox gene cluster.
- Gene regulation in spermatogenesis.
- Atypical Kunitz-type serine proteinase inhibitors produced by the ruminant placenta.
- Life-threatening Anaphylaxis to venom immunotherapy in a patient taking an angiotensin-converting enzyme inhibitor.
- Angioedema and AT1 receptor blockers: proceed with caution.
- Family of Kunitz proteins from trophoblast: expression of the trophoblast Kunitz domain proteins (TKDP) in cattle and sheep.
- IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of Asthma.
- Loss of CDH1 and pten accelerates cellular invasiveness and angiogenesis in the mouse uterus.
- Regulated Expression of Rhox8 in the Mouse Ovary: Evidence for the Role of Progesterone and RHOX5 in Granulosa Cells.
- Indirect T cell allorecognition and alloantibody-mediated rejection of MHC class I-disparate heart grafts.
- Pulmonary response to inhaled antigen: neuroImmune interactions promote the recruitment of dendritic cells to the lung and the cellular Immune response to inhaled anti...
- Characterization of a monoclonal antibody (6G12) recognizing the cynomolgus monkey CD3 antigen.
- Perirectal hematoma presenting as purpura.
- Adverse reactions to heparin.
- Critiques of research on nursing care of the elderly.
- Nursing care of the elderly.
- The genetics of atopy and Atopic eczema.
- Sequestration of inhaled particulate antigens by lung phagocytes. A mechanism for the effective inhibition of Pulmonary cell-mediated immunity.
- The transcription factor early growth-response factor 1 modulates tumor necrosis factor-alpha, immunoglobulin E, and airway responsiveness in mice.
- The Effect of an anti-CD3 monoclonal antibody on bleomycin-induced lymphokine production and lung injury.
- Vancomycin hypersensitivity: synergism with narcotics and "desensitization" by a rapid continuous intravenous protocol.
- Anti-CD3:anti-IL-2 receptor bispecific monoclonal antibody. Targeting of activated T cells in vitro.
- Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced Pulmonary inflammation.
- Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue Eosinophilia.
- IP-10 is critical for Effector T cell trafficking and host survival in Toxoplasma gondii infection.
- Rapid oral challenge-desensitization for patients with aspirin-related urticaria-Angioedema.
- Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of Asthma.
- Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1.
- T cell-dependent regulation of eotaxin in antigen-induced Pulmonary eosinophila.
- Delayed wound healing and disorganized neovascularization in transgenic mice expressing the IP-10 chemokine.
- Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in Allergic pulmonary inflammation.
- Anti-CD3:anti-IL-2 receptor-bispecific mAb-mediated immunomodulation. Low systemic Toxicity, differential effect on lymphoid tissue, and inhibition of cell-mediated hy...
- Antigen-induced airway hyperresponsiveness, Pulmonary eosinophilia, and chemokine expression in B cell-deficient mice.
- CC chemokine receptor-2 is not essential for the development of antigen-induced Pulmonary eosinophilia and airway hyperresponsiveness.
- Isolation of Sertoli, Leydig, and spermatogenic cells from the mouse testis.
- The Rhox genes.
- An alternative branch of the nonsense-mediated decay pathway.
- Rapid evolution of the trophoblast kunitz domain proteins (TKDPs)-a multigene family in ruminant ungulates.
- Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis.
Schools
McGill University Faculty Of Medicine
Mass Gen Hospital
Royal Victoria Hospital
Procedures Preformed
- Allergy Shots
- Allergy Shots for Insect Stings
- Allergy Skin Testing
Conditions Treated
- Allergic Rhinitis
- Anaphylaxis
- Angioedema
- Asthma
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Doctors Specialties
- Internal Medicine
- Allergy
- Immunology
Accepted Insurances
Awards
- America's Top Doctors
- CMS Meaningful Use Stage 1 Certification
- Boston Magazine
- Boston Herald
- Fellow (FAAAAI)
- Super Doctor
- Top MD
Education
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Massachusetts General Hospital -
McGill University Faculty of Medicine
Hospital
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Massachusetts General Hospital -
Beverly Hospital
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