Associate Professor of Pathology, Massachusetts General Hospital
Pathology
Dr. Jae K. Joung, MD
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Joung is an expert in the field of Pathology. He went to Harvard Medical School. Harvard Medical School is a one of the best medicals schools. Harvard Medical School is ranked 1 in research and 12 in primary care medicine He has 12 awards "Elected Member", "Burroughs Wellcome Lecturer", "The Jim & Ann Orr MGH Research Scholar", "Resource Sharing Award", "NIH Directors Pioneer Award Recipient", "NIH Transformative R01 recipient", "Honoree, The One Hundred", "Post-doctoral Research Fellowship for Physicians", "Bernard N. Fields Prize in Microbiology & Molecular Genetics", "Certificate of Distinction in Teaching", "Medical Scientist Training Program, (MSTP; M.D.-Ph.D. program) appointment" and "M.D.-Ph.D. Scholarship Award". Doctor Jae K. Joung, MD is a published MD as well. He has 35 publications published. The latest was: Accelerating research through reagent repositories: the genome editing example.
Publications
- Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition.
- CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants.
- Chromatin regulation at the frontier of synthetic biology.
- Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.
- A Zebrafish Model of Myelodysplastic Syndrome Produced Through tet2 Genomic Editing.
- GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases.
- Genome Editing: A Tool For Research and Therapy: Towards a functional understanding of variants for molecular diagnostics using genome editing.
- Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo.
- Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.
- IκB Kinase β (IKBKB) Mutations in Lymphomas That Constitutively Activate Canonical Nuclear Factor κB (NFκB) Signaling.
- What's Changed with Genome Editing?
- Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1.
- Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing.
- Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function.
- CRISPR-Cas systems for editing, regulating and targeting genomes.
- Toddler: an embryonic signal that promotes cell movement via Apelin receptors.
- Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity.
- Improving CRISPR-Cas nuclease specificity using truncated guide RNAs.
- Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.
- Correction of Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair.
- Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.
- High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells.
- Locus-specific editing of histone modifications at endogenous enhancers.
- In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites.
- CRISPR RNA-guided activation of endogenous human genes.
- Engineering Customized TALE Nucleases (TALENs) and TALE Transcription Factors by Fast Ligation-Based Automatable Solid-Phase High-Throughput (FLASH) Assembly.
- Robust, synergistic regulation of human gene expression using TALE activators.
- Efficient genome editing in zebrafish using a CRISPR-Cas system.
- TALENs: a widely applicable technology for targeted genome editing.
- Engineering Designer Transcription Activator--Like Effector Nucleases (TALENs) by REAL or REAL-Fast Assembly.
- Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs.
- Improved Somatic Mutagenesis in Zebrafish Using Transcription Activator-Like Effector Nucleases (TALENs).
- Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System.
- Accelerating research through reagent repositories: the genome editing example.
Schools
Harvard Medical School
Ma Gen Hospital
Doctors Specialties
- Clinical Pathology
- Pathology
Accepted Insurances
Awards
- Elected Member
- Burroughs Wellcome Lecturer
- The Jim & Ann Orr MGH Research Scholar
- Resource Sharing Award
- NIH Director’s Pioneer Award Recipient
- NIH Transformative R01 recipient
- Honoree, The One Hundred
- Post-doctoral Research Fellowship for Physicians
- Bernard N. Fields Prize in Microbiology & Molecular Genetics
- Certificate of Distinction in Teaching
- Medical Scientist Training Program, (MSTP; M.D.-Ph.D. program) appointment
- M.D.-Ph.D. Scholarship Award
Education
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Massachusetts General Hospital -
Harvard University -
Harvard Medical School -
Harvard College
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