Professor, Pathology-Brigham and Women's Hospital, Harvard Medical School
Pathology
Dr. Mel B. Feany, MD
Feany works in the field of Pathology. She attended Albert Einstein College of Medicine of Yeshiva University. Feany is a published MD as well. She has 36 publications published. The latest was: An In Vivo Pharmacological Screen Identifies Cholinergic Signaling as a Therapeutic Target in Glial-Based Nervous System Disease. She accepts Medicare.
Publications
- Connecting the dots between tau dysfunction and neurodegeneration.
- Glia are critical for the neuropathology of complex I deficiency in Drosophila.
- Tau promotes neurodegeneration through global chromatin relaxation.
- Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms.
- Why size matters - balancing mitochondrial dynamics in Alzheimer's disease.
- Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo.
- A neuroprotective role for the DNA damage checkpoint in tauopathy.
- Parkinson's disease: genetics and pathogenesis.
- Protein misfolding and oxidative stress promote glial-mediated neurodegeneration in an Alexander disease model.
- Functional screening of Alzheimer pathology genome-wide association signals in Drosophila.
- Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy.
- Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
- ASIP Outstanding Investigator Award Lecture. New approaches to the pathology and genetics of neurodegeneration.
- The unfolded protein response protects from tau neurotoxicity in vivo.
- Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.
- Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.
- Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.
- In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons.
- Tau phosphorylation sites work in concert to promote neurotoxicity in vivo.
- Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.
- S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila.
- Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation.
- Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.
- Oxidative stress mediates tau-induced neurodegeneration in Drosophila.
- Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome.
- Senseless makes sense for spinocerebellar ataxia-1.
- Cathepsin D-deficient Drosophila recapitulate the key features of neuronal ceroid lipofuscinoses.
- Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease.
- Proliferative potential of human astrocytes.
- New genetic insights into Parkinson's disease.
- Genetic modifiers of tauopathy in Drosophila.
- Polyglutamines stop traffic: axonal transport as a common target in neurodegenerative diseases.
- Parkin: a multipurpose neuroprotective agent?
- Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants.
- An In Vivo Pharmacological Screen Identifies Cholinergic Signaling as a Therapeutic Target in Glial-Based Nervous System Disease.
Schools
Albert Einstein College of Medicine of Yeshiva University
Brigham and Women39s Hospital
Doctors Specialties
- Neuropathology
- Pathology
Accepted Insurances
Education
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Brigham and Women's Hospital -
Albert Einstein College of Medicine of Yeshiva University
Hospital
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Brigham and Women's Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1073540258 |
| Last Name Of The Provider | FEANY |
| First Name Of The Provider | MEL |
| View All |
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