Physician
Infectious Disease
Dr. Harry L. Malech, MD
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Dr. Harry L. Malech is an expert in the field of Infectious Disease. He went to Yale University School of Medicine. Yale University School of Medicine is a top medical university. Yale University School of Medicine is ranked 7 in research and 57 in primary care medicine He received 1 awards: "Elected Member". Harry Malech is a published doctor. He published 98 publications, including: 'Molecular analysis of neutrophil differentiation from human iPSCs delineates the kinetics of key regulators of hematopoiesis.'
Publications
- Gastrointestinal Features of Chronic Granulomatous Disease Found During Endoscopy.
- Gene therapy studies in a canine model of x-linked severe combined immunodeficiency.
- qsLAM PCR, an improved method for quantifying lentiviral vector insertion sites in transplanted hematopoietic cell systems.
- An AAVS1-targeted Minigene Platform for Correction of iPSCs from All Five Types of Chronic Granulomatous Disease.
- Assessment of Atherosclerosis in Chronic Granulomatous Disease.
- Mobilization characteristics and strategies to improve hematopoietic progenitor cell mobilization and collection in patients with chronic granulomatous disease and sev...
- Charting a Clear Path: The ASGCT Standardized Pathways Conference.
- Paravertebral Mushroom: Identification of a novel species of Phellinus as a Human Pathogen in Chronic Granulomatous Disease.
- Recurrent erythematous plaques on sun-exposed sites in an African American boy with chronic granulomatous disease.
- Enhancers Are Major Targets for MLV Vector Integration.
- False-Positive HIV PCR Test Following Ex Vivo Lentiviral Gene Transfer Treatment of X-linked Severe Combined Immunodeficiency Vector.
- A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor.
- B-cell activating factor (BAFF) is elevated in Chronic Granulomatous Disease.
- The role of surgery in the management of patients with refractory chronic granulomatous disease colitis.
- Pegylated siRNA-loaded calcium phosphate nanoparticle-driven amplification of cancer cell internalization in vivo.
- Transgene-free iPSCs generated from small volume peripheral blood non-mobilized CD34+ cells.
- Diabetes, Renal and Cardiovascular Disease in p47( phox-/-) Chronic Granulomatous Disease.
- Adenosine A2A receptor agonist-mediated increase in donor-derived regulatory T cells suppresses development of graft-versus-host disease.
- Humans with chronic granulomatous disease maintain humoral immunologic memory despite low frequencies of circulating memory B cells.
- Serologic Reactivity to the Emerging Pathogen Granulibacter bethesdensis.
- Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy.
- Innate immunity against Granulibacter bethesdensis, an emerging Gram-negative bacterial pathogen.
- Corticosteroid therapy for liver abscess in chronic granulomatous disease.
- The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome.
- Chronic granulomatous disease: Overview and hematopoietic stem cell transplantation.
- Oxidase deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease mediated safe harbor targeting.
- Geosmithia argillacea: an emerging cause of invasive mycosis in human chronic granulomatous disease.
- Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells.
- High levels of Crohn's disease-associated anti-microbial antibodies are present and independent of colitis in chronic granulomatous disease.
- Residual NADPH oxidase and survival in chronic granulomatous disease.
- Characterization of retroviral and lentiviral vectors pseudotyped with xenotropic murine leukemia virus-related virus envelope glycoprotein.
- AMD3100 is a Potent Antagonist at CXCR4(R334X) , a Hyperfunctional Mutant Chemokine Receptor and Cause of WHIM Syndrome.
- Hematologically important mutations: X-linked chronic granulomatous disease (third update).
- Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis.
- Tryptophan/kynurenine metabolism in human leukocytes is independent of superoxide and is fully maintained in chronic granulomatous disease.
- Recurrent Granulibacter bethesdensis infections and chronic granulomatous disease.
- Hypomorphic Rag mutations can cause destructive midline granulomatous disease.
- A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells.
- Hematologically important mutations: the autosomal recessive forms of chronic granulomatous disease (second update).
- Adenosine A2A receptor activation limits graft-versus-host disease after allogenic hematopoietic stem cell transplantation.
- Retrovirus gene therapy for X-linked chronic granulomatous disease can achieve stable long-term correction of oxidase activity in peripheral blood neutrophils.
- Skin ulcers and disseminated abscesses are characteristic of Serratia marcescens infection in older patients with chronic granulomatous disease.
- In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.
- Functional neutrophils from human ES cells.
- Mucormycosis in chronic granulomatous disease: association with iatrogenic immunosuppression.
- Efficient construction of producer cell lines for a SIN lentiviral vector for SCID-X1 gene therapy by concatemeric array transfection.
- WHIM syndrome: congenital immune deficiency disease.
- Advances in treatment for chronic granulomatous disease.
- Partially corrected X-linked severe combined immunodeficiency: long-term problems and treatment options.
- Rippled skin, fasciitis, and joint contractures.
- Chronic granulomatous disease as a risk factor for autoimmune disease.
- Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population.
- Hepatic involvement and portal hypertension predict mortality in chronic granulomatous disease.
- STAT3 mutations in the hyper-IgE syndrome.
- Primary immunodeficiency: meeting the challenges.
- The late dividing population of gamma-retroviral vector transduced human mobilized peripheral blood progenitor cells contributes most to gene-marked cell engraftment i...
- Gene therapy improves immune function in preadolescents with X-linked severe combined immunodeficiency.
- Diprotin A infusion into nonobese diabetic/severe combined immunodeficiency mice markedly enhances engraftment of human mobilized CD34+ peripheral blood cells.
- Hepatic abnormalities in patients with chronic granulomatous disease.
- The role of neutrophils in the immune system: an overview.
- The K-562 cell model for analysis of neutrophil NADPH oxidase function.
- WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4.
- Genetics, biology and clinical management of myeloid cell primary immune deficiencies: chronic granulomatous disease and leukocyte adhesion deficiency.
- Analysis of human phagocyte flavocytochrome b(558) by mass spectrometry.
- Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative transplantation with transduced autologous peripheral blood progenitor cells.
- Patients with chronic granulomatous disease have a reduced peripheral blood memory B cell compartment.
- Correction of canine X-linked severe combined immunodeficiency by in vivo retroviral gene therapy.
- Gene therapy for immune disorders: good news tempered by bad news.
- Sarcoidosis in chronic granulomatous disease.
- Unique abnormalities of CD4(+) and CD8(+) central memory cells associated with chronic graft-versus-host disease improve after extracorporeal photopheresis.
- HIF-1alpha: a master regulator of innate host defenses?
- Improved transduction of human sheep repopulating cells by retrovirus vectors pseudotyped with feline leukemia virus type C or RD114 envelopes.
- Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection.
- Cloning and functional analysis of the rhesus macaque ABCG2 gene. Forced expression confers an SP phenotype among hematopoietic stem cell progeny in vivo.
- Long-term interferon-gamma therapy for patients with chronic granulomatous disease.
- Gastrointestinal involvement in chronic granulomatous disease.
- Severe chronic graft-versus-host disease is characterized by a preponderance of CD4(+) effector memory cells relative to central memory cells.
- Cognitive function in patients with chronic granulomatous disease: a preliminary report.
- Pediatric large-volume leukapheresis: a single institution experience with heparin versus citrate-based anticoagulant regimens.
- Gene expression profiling provides insight into the pathophysiology of chronic granulomatous disease.
- CXCR4-transgene expression significantly improves marrow engraftment of cultured hematopoietic stem cells.
- Severe phenotype of chronic granulomatous disease presenting in a female with a de novo mutation in gp91-phox and a non familial, extremely skewed X chromosome inactiv...
- Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta ...
- Persistent Mycobacterium avium infection following nonmyeloablative allogeneic peripheral blood stem cell transplantation for interferon-gamma receptor-1 deficiency.
- NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes.
- Itraconazole to prevent fungal infections in chronic granulomatous disease.
- Reinfection, rather than persistent infection, in patients with chronic granulomatous disease.
- An apoptosis-differentiation program in human polymorphonuclear leukocytes facilitates resolution of inflammation.
- Diagnostic paradigm for evaluation of male patients with chronic granulomatous disease, based on the dihydrorhodamine 123 assay.
- Third-generation, self-inactivating gp91(phox) lentivector corrects the oxidase defect in NOD/SCID mouse-repopulating peripheral blood-mobilized CD34+ cells from patie...
- Nocardia infection in chronic granulomatous disease.
- Retroviral transduction of IL2RG into CD34(+) cells from X-linked severe combined immunodeficiency patients permits human T- and B-cell development in sheep chimeras.
- CYBB mutation analysis in X-linked chronic granulomatous disease.
- Hepatic abscess in patients with chronic granulomatous disease.
- Generation of functionally mature neutrophils from induced pluripotent stem cells.
- Molecular analysis of neutrophil differentiation from human iPSCs delineates the kinetics of key regulators of hematopoiesis.
- Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease.
Schools
Yale University
Hospital Penn
Yale New Haven Hospital
Doctors Specialties
- Internal Medicine
- Infectious Disease
Accepted Insurances
Awards
- Elected Member
Education
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University of Pennsylvania Health System -
Yale University School of Medicine
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