Physician
Oncology
Dr. Richard J. Hodes, MD
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Doctor Richard J. Hodes, MD practices Oncology. He graduated from Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. He over the years received 1 awards: "Elected Member". Richard J. Hodes, MD has written publications. He has 102 publications published with PubMed. The lastest publication is: 'Regulation of telomere length and telomerase in T and B cells: a mechanism for maintaining replicative potential.'
Publications
- Age-associated telomere attrition of lymphocytes in vivo is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions.
- T Cell-B Cell Thymic Cross-Talk: Maintenance and Function of Thymic B Cells Requires Cognate CD40-CD40 Ligand Interaction.
- Regulation of T cell development by c-Cbl: essential role of Lck.
- Downmodulation of Tumor Suppressor p53 by T Cell Receptor Signaling Is Critical for Antigen-Specific CD4(+) T Cell Responses.
- A Novel T Cell Subset with Trans-Rearranged Vγ-Cβ TCRs Shows Vβ Expression Is Dispensable for Lineage Choice and MHC Restriction.
- Thymic Medullary Epithelium and Thymocyte Self-Tolerance Require Cooperation between CD28-CD80/86 and CD40-CD40L Costimulatory Pathways.
- TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.
- The NIH toolbox: setting a standard for biomedical research.
- Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes.
- Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes.
- Exon 1 Disruption Alters Tissue-Specific Expression of Mouse p53 and Results in Selective Development of B Cell Lymphomas.
- National institute on aging at middle age-its past, present, and future.
- Epidemiology, comparative effectiveness research, and the National Institutes of Health: forces for health.
- The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.
- Cbl enforces vav1 dependence and a restricted pathway of T cell development.
- Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl.
- Telomere length is inherited with resetting of the telomere set-point.
- Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice.
- Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation.
- Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms.
- Aging in the context of immunological architecture, function and disease outcomes.
- Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation.
- Prospects for life span extension.
- Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence.
- Regulation of thymic NKT cell development by the B7-CD28 costimulatory pathway.
- Eyes on the prize: federal Alzheimer's research effort aims to facilitate interventions.
- Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.
- ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor alpha locus coding end breaks.
- Ablation of Cbl-b provides protection against transplanted and spontaneous tumors.
- Redundancy in B cell developmental pathways: c-Cbl inactivation rescues early B cell development through a B cell linker protein-independent pathway.
- Persistence of tumor infiltrating lymphocytes in adoptive immunotherapy correlates with telomere length.
- Abnormal differentiation of memory T cells in systemic lupus erythematosus.
- Public funding for Alzheimer disease research in the United States.
- Response to: "Rescuing the NIH before it is too late".
- Getting it right: being smarter about clinical trials.
- Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice.
- National Institute on Aging. Interview by Vicki Glaser.
- Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element.
- Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27.
- Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy.
- Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint.
- In vivo regulation of telomerase activity and telomere length.
- Telomere biology and immune system.
- Fetal expression of Fas ligand is necessary and sufficient for induction of CD8 T cell tolerance to the fetal antigen H-Y during pregnancy.
- The future of aging therapies.
- A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection.
- Immunoglobulin class switch recombination is impaired in Atm-deficient mice.
- Don't forget to prescribe exercise for your older patients.
- Analysis of telomere length and telomerase activity.
- Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway.
- Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor.
- Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo.
- Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice.
- Transcriptome analysis of mouse stem cells and early embryos.
- Differential requirements for expression of CD80/86 and CD40 on B cells for T-dependent antibody responses in vivo.
- CD28 costimulation is required for in vivo induction of peripheral tolerance in CD8 T cells.
- Induction of telomerase activity and maintenance of telomere length in virus-specific effector and memory CD8+ T cells.
- Telomeres in T and B cells.
- RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice.
- The effects of aging on lymphocyte development and function: introduction.
- Haploinsufficiency of mTR results in defects in telomere elongation.
- CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes.
- Visiting Solomon: AIDS in Ethiopia.
- Molecular targeting of cancer: telomeres as targets.
- Mouse endogenous superantigens: Ms and Mls-like determinants encoded by mouse retroviruses.
- Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT p...
- Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age.
- The role of telomerase expression and telomere length maintenance in human and mouse.
- Encouraging older patients to exercise.
- Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice.
- The role of B7 costimulation in CD4/CD8 T cell homeostasis.
- Telomere length, aging, and somatic cell turnover.
- Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes.
- Consensus report of the Working Group on: molecular and biochemical markers of Alzheimer's disease.
- Regulation of telomere length and telomerase in T and B cells: a mechanism for maintaining replicative potential.
- Telomere length regulation in mice is linked to a novel chromosome locus.
- Cutting edge: antigen-dependent regulation of telomerase activity in murine T cells.
- The role of B7-CD28 co-stimulation in tumor rejection.
- Productive infection of neonatal CD8+ T lymphocytes by HIV-1.
- Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging.
- Aging and the immune system.
- Meeting the challenges of an aging population.
- Telomere lengthening and telomerase activation during human B cell differentiation.
- What does cell death have to do with aging?
- Telomere length, telomerase activity, and replicative potential in HIV infection: analysis of CD4+ and CD8+ T cells from HIV-discordant monozygotic twins.
- Regulation of telomerase RNA template expression in human T lymphocyte development and activation.
- Tissue-specific and growth-regulated expression of CD44 variable exon determinants in the mouse.
- Cross-cultural medicine and diverse health beliefs. Ethiopians abroad.
- Longevity assurance genes: how do they influence aging and life span?
- Regulated expression of telomerase activity in human T lymphocyte development and activation.
- The role of CD28 costimulation in immune-mediated responses against mouse mammary tumor viruses.
- The National Institute on Aging at its twentieth anniversary: achievements and promise of research on aging.
- Role of the CD28-B7 costimulatory pathways in T cell-dependent B cell responses.
- Inhibition of transplant rejection following treatment with anti-B7-2 and anti-B7-1 antibodies.
- Human naive and memory T lymphocytes differ in telomeric length and replicative potential.
- Analysis of thymic subpopulations expressing the activation antigen GL7. Expression, genetics, and function.
- Sensitivity of Plasmodium falciparum in vivo to chloroquine and pyrimethamine-sulfadoxine in Rwandan patients in a refugee camp in Zaire.
- Communicating with older patients: a challenge for researchers and clinicians.
- Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.
- Molecular alterations in the aging immune system.
- Accelerating Medicines Partnership: Alzheimer's Disease (AMP-AD) Knowledge Portal Aids Alzheimer's Drug Discovery through Open Data Sharing.
Schools
Harvard Medical School
Massachusetts General Hospital
Doctors Specialties
- Internal Medicine
- Oncology
Accepted Insurances
Awards
- Elected Member
Education
-
Massachusetts General Hospital -
Harvard Medical School
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