Steelers Chair in Transplantation, Professor of Surgery, Medicine, and Immunology
Nephrology
Dr. David M. Rothstein, MD
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Dr. David M. Rothstein works in the field of Nephrology. He went to Perelman School of Medicine at the University of Pennsylvania. David Rothstein is a published doctor. He has 101 publications published. The most current publication "A correlation between turnover rates and lipophilic affinities of soluble rat liver proteins."
Publications
- TIM4 regulates the anti-islet Th2 alloimmune response.
- Allograft outcomes in outbred mice.
- Innate immunity alone is not sufficient for Chronic rejection but predisposes healed allografts to T cell-mediated pathology.
- Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice.
- Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice.
- Rapamycin Combined With Anti-CD45RB mAb and IL-10 or With G-CSF Induces Tolerance in a Stringent Mouse Model of Islet Transplantation.
- Intramuscular transplantation of human postnatal myoblasts generates functional donor-derived satellite cells.
- NK cells delay allograft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of CD8+ T cells.
- An innate response to allogeneic nonself mediated by monocytes.
- A case for immunosuppression for myoblast transplantation in duchenne muscular dystrophy.
- CTLA4 expression is an indicator and regulator of steady-state CD4+ FoxP3+ T cell homeostasis.
- Central tolerance to myogenic cell transplants does not include muscle neoantigens.
- Efficacy of benzoxazinorifamycins in a mouse model of Chlamydia pneumoniae lung infection.
- The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model.
- PDL1 is required for peripheral transplantation tolerance and protection from Chronic allograft rejection.
- CD45RB ligation inhibits allergic pulmonary inflammation by inducing CTLA4 transcription.
- Efficacy of a novel rifamycin derivative, ABI-0043, against Staphylococcus aureus in an experimental model of foreign-body infection.
- Efficacy of novel rifamycin derivatives against rifamycin-sensitive and -resistant Staphylococcus aureus isolates in murine models of infection.
- Immunosuppression and regulation: cast in new light?
- Activity of novel benzoxazinorifamycins against rifamycin-resistant Streptococcus pyogenes.
- In vitro activity of novel rifamycins against rifamycin-resistant Staphylococcus aureus.
- Antigen exposure during enhanced CTLA-4 expression promotes allograft tolerance in vivo.
- Rifalazil pretreatment of mammalian cell cultures prevents subsequent Chlamydia infection.
- Requirements for induction and maintenance of peripheral tolerance in stringent allograft models.
- Activities of rifamycin derivatives against wild-type and rpoB mutants of Chlamydia trachomatis.
- Testicular immune privilege promotes transplantation tolerance by altering the balance between memory and regulatory T cells.
- Rifampin-resistant RNA polymerase mutants of Chlamydia trachomatis remain susceptible to the ansamycin rifalazil.
- Impaired recall of CD8 memory T cells in immunologically privileged tissue.
- Activation of HTLV-I gene transcription by protein tyrosine phosphatase inhibitors.
- Cutting edge: transplantation tolerance through enhanced CTLA-4 expression.
- CD45RB-targeting strategies for promoting long-term allograft survival and preventingChronic allograft vasculopathy.
- Prolonged islet allograft survival in diabetic NOD mice by targeting CD45RB and CD154.
- Islet filtration: a simple and rapid new purification procedure that avoids ficoll and improves islet mass and function.
- Nuclear factor of activated T cells is a driving force for preferential productive HIV-1 infection of CD45RO-expressing CD4+ T cells.
- Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance.
- Efficacy of superoxide dismutase mimetic M40403 in attenuating radiation-induced oral mucositis in hamsters.
- Graft-versus-host Disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells.
- Role of glnA-linked genes in regulation of glutamine synthetase and histidase formation in Klebsiella aerogenes.
- Induction of tolerance across fully mismatched barriers by a nonmyeloablative treatment Excluding antibodies or irradiation use.
- Antimicrobial activity of silver nitrate against periodontal pathogens.
- Prolonged survival of allogeneic islet grafts in NOD mice treated With a combination of anti-CD45RB and anti-CD154 antibodies.
- The same epitope on CD22 of B lymphocytes mediates the adhesion of erythrocytes, T and B lymphocytes, neutrophils, and monocytes.
- Identification and analysis of bacterial protein secretion inhibitors utilizing a SecA-LacZ reporter fusion system.
- Human antigen-specific memory T cells express the homing receptor (LAM-1) necessary for lymphocyte recirculation.
- Rifalazil treats and prevents relapse of clostridium difficile-associated diarrhea in hamsters.
- Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4⺠effector memory T cells.
- Type I interferons are not critical for skin allograft rejection or the generation of donor-specific CD8+ memory T cells.
- P-113D, an antimicrobial peptide active against Pseudomonas aeruginosa, retains activity in the presence of sputum from cystic fibrosis patients.
- Multiphoton intravital microscopy of the transplanted mouse Kidney.
- Complex glnA-glnL-glnG operon of Escherichia coli.
- Regulation of expression from the glnA promoter of Escherichia coli in the absence of glutamine synthetase.
- Isolation of Klebsiella aerogenes mutants cis-dominant for glutamine synthetase expression.
- Clostridium thermosaccharolyticum strain deficient in acetate production.
- Thermoinducible transcription system for Bacillus subtilis that utilizes control elements from temperate phage phi 105.
- Mutations that create new promoters suppress the sigma 54 dependence of glnA transcription in Escherichia coli.
- Expression of alpha-amylase in Bacillus licheniformis.
- Transcription from the P1 promoters of Micromonospora echinospora in the absence of native upstream DNA sequences.
- Requirements for the induction of allospecific CD8+ suppressor T cells in the rat primary mixed lymphocyte response. CD4+, CD45R+ T cells, or supernatant factor.
- Functional characterization of the CD45R (2H4) molecule on CD8 (T8) cells in the autologous mixed lymphocyte reaction system.
- Transcription efficiency along the tissue-plasminogen-activator cDNA gene in Escherichia coli.
- Temporally regulated tandem promoters in Micromonospora echinospora.
- Sulfadiazine crystalluria revisited. The treatment of Toxoplasma encephalitis in patients With acquired immunodeficiency syndrome.
- Effect of activation of protein kinase C on CD45 isoform expression and CD45 protein tyrosine phosphatase activity in T cells.
- Sensitive biological detection method for tetracyclines using a tetA-lacZ fusion system.
- CD4 heterogeneity: implications for immunoregulation.
- Isolation of mutants blocked in calicheamicin biosynthesis.
- Molecular basis of tetracycline action: identification of analogs whose primary target is not the bacterial ribosome.
- Phenotypic abnormalities in CD8+ T lymphocyte subsets in patients With rheumatoid arthritis.
- CD45 isoforms associated With distinct functions of CD4 cells derived from unusual healthy donors lacking CD45RA- T lymphocytes.
- CD4+CD45RA+ and CD4+CD45RA- T cell subsets in man maintain distinct function and CD45RA expression persists on a subpopulation of CD45RA+ cells after activation With C...
- The functional heterogeneity of CD8+ cells defined by anti-CD45RA (2H4) and anti-CD29 (4B4) antibodies.
- Cyclic regulation of CD45 isoform expression in a long term human CD4+CD45RA+ T cell line.
- Conditions for protoplasting, regenerating, and transforming the calicheamicin producer, Micromonospora echinospora.
- Mutations in the P1 promoter region of Micromonospora echinospora.
- CD45 isoform expression on human neonatal T cells: expression and turnover of CD45 isoforms on neonatal versus adult T cells after activation.
- The alternative splicing of the CD45 tyrosine phosphatase is controlled by negative regulatory trans-acting splicing factors.
- Genetic analysis of the tetA(C) gene on plasmid pBR322.
- Evidence of presymptomatic cognitive decline in Huntington''s Disease.
- Micromonospora RNA polymerase activity changes during stationary phase.
- Activation of T cells through a T cell-specific epitope of CD45.
- Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein.
- CD27, a member of the nerve growth factor receptor family, is preferentially expressed on CD45RA+ CD4 T cell clones and involved in distinct immunoregulatory functions.
- CD31, a novel cell surface marker for CD4 cells of suppressor lineage, unaltered by state of activation.
- A correlation between turnover rates and lipophilic affinities of soluble rat liver proteins.
- Lipiarmycin-resistant ribonucleic acid polymerase mutants of Bacillus subtilis.
- CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling.
- CTLA-4 up-regulation plays a role in tolerance mediated by CD45.
- Targeting signal 1 through CD45RB synergizes With CD40 ligand blockade and promotes long term engraftment and tolerance in stringent transplant models.
- Photoactive porphyrin derivative With broad-spectrum activity against oral pathogens In vitro.
- Sustained release of silver from periodontal wafers for treatment of periodontitis.
- Genetic analysis suggests functional interactions between the N- and C-terminal domains of the TetA(C) efflux pump encoded by pBR322.
- Distinct isoforms of the CD45 protein-tyrosine phosphatase differentially regulate interleukin 2 secretion and activation signal pathways involving Vav in T cells.
- Promoters regulated by the glnG (ntrC) and nifA gene products share a heptameric consensus sequence in the -15 region.
- The second domain of the CD45 protein tyrosine phosphatase is critical for interleukin-2 secretion and substrate recruitment of TCR-zeta in vivo.
- Screening systems for detecting inhibitors of cell wall transglycosylation in Enterococcus. Cell wall transglycosylation inhibitors in Enterococcus.
- Antibody-mediated targeting of CD45 isoforms: a novel immunotherapeutic strategy.
- Indefinite islet allograft survival in mice after a short course of treatment With anti-CD45 monoclonal antibodies.
- Anti-CD45RB treatment prolongs islet allograft survival in mice.
- Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase.
- Expression of the tetK gene from Staphylococcus aureus in Escherichia coli: comparison of substrate specificities of TetA(B), TetA(C), and TetK efflux proteins.
Schools
University Of Pennsylvania School Of Medicine
Hospital Of The University Of Pennsylvania
Brigham Womens Hospital
Procedures Preformed
- Hemodialysis
Conditions Treated
- Acidosis
- Acute Kidney Failure
- Chronic Kidney Diseases
- Diabetes With Renal Manifestations
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Doctors Specialties
- Nephrology
Accepted Insurances
Education
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Brigham and Women's Hospital -
University of Pennsylvania Health System -
Perelman School of Medicine at the University of Pennsylvania
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