Professor, Medicine, University of California Los Angeles David Geffen SOM

Infectious Disease

David A. Haake practices Infectious Disease. He researched medicine at NYU School of Medicine. Doctor David A. Haake, MD is a published physician. He published 101 publications, including: 'Expression and distribution of leptospiral outer membrane components during renal infection of hamsters.'

Publications

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• Role of sph2 Gene Regulation in Hemolytic and Sphingomyelinase Activities Produced by Leptospira interrogans.
• Intracellular Bacterial Communities: A Potential Etiology for Chronic Lower Urinary Tract Symptoms.
• Kinetics of Leptospira interrogans Infection in Hamsters after Intradermal and Subcutaneous Challenge.
• Identification of Cell-Binding Adhesins of Leptospira interrogans.
• Emerging technologies for rapid identification of bloodstream pathogens.
• Oral Immunization with Escherichia coli Expressing a Lipidated Form of LigA Protects Hamsters against Challenge with Leptospira interrogans Serovar Copenhageni.
• Oral immunization with E. coli expressing a lipidated form of LigA protects hamsters against challenge with Leptospira interrogans serovar Copenhageni.
• A role for cis-acting RNA sequences in the temperature-dependent expression of the multiadhesive Lig proteins in Leptospira interrogans.
• Rapid Antimicrobial Susceptibility Testing by Sensitive Detection of Precursor rRNA Using a Novel Electrochemical Biosensing Platform.
• LipL32 Is a Subsurface Lipoprotein of Leptospira interrogans: Presentation of New Data and Reevaluation of Previous Studies.
• Antibodies to a novel leptospiral protein, LruC, in the eye fluids and sera of horses with Leptospira-associated uveitis.
• Three-Dimensional Structures of Pathogenic and Saprophytic Leptospira Revealed by Cryo-Electron Tomography.
• Methylation and in vivo expression of the surface-exposed Leptospira interrogans outer membrane protein OmpL32.
• A LigA Three-Domain Region Protects Hamsters from Lethal Infection by Leptospira interrogans.
• Target Specific Capture Enhances Sensitivity of Electrochemical Detection of Bacterial Pathogens.
• Heterologous expression of pathogen-specific genes ligA and ligB in the saprophyte Leptospira biflexa confers enhanced adhesion to cultured cells and fibronectin.
• Interactions of leptospira with environmental bacteria from surface water.
• The multifunctional LigB adhesin binds homeostatic proteins with potential roles in cutaneous infection by pathogenic Leptospira interrogans.
• Transcriptional response of Leptospira interrogans to iron limitation and characterization of a PerR homolog.
• Ternary Surface Monolayers for Ultrasensitive (Zeptomole) Amperometric Detection of Nucleic Acid Hybridization without Signal Amplification.
• Leptospira: a spirochaete with a hybrid outer membrane.
• The OmpL37 surface-exposed protein is expressed by pathogenic Leptospira during infection and binds skin and vascular elastin.
• Bacterial biofilm disruption using laser generated shockwaves.
• Potentiometric detection of DNA hybridization using enzyme-induced metallization and a silver ion selective electrode.
• Multiplex pathogen identification for polymicrobial urinary tract infections using biosensor technology: a prospective clinical study.
• Leptospira interrogans stably infects zebrafish embryos, altering phagocyte behavior and homing to specific tissues.
• A comprehensive approach to identification of surface-exposed, outer membrane-spanning proteins of Leptospira interrogans.
• Uropathogens and host characteristics.
• Optimal probe length and target location for electrochemical detection of selected uropathogens at ambient temperature.
• Rapid antimicrobial susceptibility determination of uropathogens in clinical urine specimens by use of ATP bioluminescence.
• An unsteady microfluidic T-form mixer perturbed by hydrodynamic pressure.
• Early diagnosis of leptospirosis by immunoglobulin M immunoblot testing.
• Response of Leptospira interrogans to physiologic osmolarity: relevance in signaling the environment-to-host transition.
• Physiological osmotic induction of Leptospira interrogans adhesion: LigA and LigB bind extracellular matrix proteins and fibrinogen.
• Leptospira immunoglobulin-like proteins as a serodiagnostic marker for acute leptospirosis.
• Development of an advanced electrochemical DNA biosensor for bacterial pathogen detection.
• Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement.
• Effects of temperature on gene expression patterns in Leptospira interrogans serovar Lai as assessed by whole-genome microarrays.
• Hamster model of leptospirosis.
• Molecular epidemiology of leptospirosis in the Amazon.
• Use of electrochemical DNA biosensors for rapid molecular identification of uropathogens in clinical urine specimens.
• LruA and LruB, novel lipoproteins of pathogenic Leptospira interrogans associated with equine recurrent uveitis.
• Leptospirosis after recreational exposure to water in the Yaeyama islands, Japan.
• Electrochemical molecular analysis without nucleic acid amplification.
• Surfaceome of Leptospira spp.
• Diagnostic and therapeutic pitfalls associated with primaquine-tolerant Plasmodium vivax.
• Osmolarity, a key environmental signal controlling expression of leptospiral proteins LigA and LigB and the extracellular release of LigA.
• Rapid, species-specific detection of uropathogen 16S rDNA and rRNA at ambient temperature by dot-blot hybridization and an electrochemical sensor array.
• Molecular evolution and mosaicism of leptospiral outer membrane proteins involves horizontal DNA transfer.
• LipL21 is a novel surface-exposed lipoprotein of pathogenic Leptospira species.
• Gastrointestinal microflora studies in late-onset autism.
• Characterization of the leptospiral outer membrane and description of three novel leptospiral membrane proteins.
• Leptospirosis, water sports, and chemoprophylaxis.
• Global analysis of outer membrane proteins from Leptospira interrogans serovar Lai.
• Novel 45-kilodalton leptospiral protein that is processed to a 31-kilodalton growth-phase-regulated peripheral membrane protein.
• An improved immunohistochemical diagnostic technique for canine leptospirosis using antileptospiral antibodies on renal tissue.
• Leptospirosis in humans.
• The leptospiral outer membrane.
• [Economic value of tiotropium in the treatment of chronic obstructive pulmonary disease].
• Technological advances in the molecular biology of Leptospira.
• Reduced concentration of secretory IgA indicates changes of local immunity in children with adenoid hyperplasia and secretory otitis media.
• Pyelonephritis, rash, and progressive respiratory failure in a pregnant woman.
• Secretion of salivary immunoglobulin A in relation to age, saliva flow, mood states, secretion of albumin, cortisol, and catecholamines in saliva.
• A 3-year cohort study on short-term effects of air pollution in Germany. 1. Influences of medication and season.
• [Neuro-otologic diagnosis after long-term exposure to wood preservatives containing pentachlorophenol].
• [A simple method for the demonstration of the bacterial spectrum in the nose and the nasopharynx in the infection-free interval in children with adenoid hypertrophy].
• [Lung function and carboxyhemoglobin during the smog episode of January 1987].
• What accounts for the interindividual variability of sIgA concentration in saliva?
• A 9.0-kilobase-pair circular plasmid of Borrelia burgdorferi encodes an exported protein: evidence for expression only during infection.
• Interjunctional invasion of endothelial cell monolayers.
• The rare outer membrane protein, OmpL1, of pathogenic Leptospira species is a heat-modifiable porin.
• The modification of human immunoglobulin binding to staphylococcal protein A using diethylpyrocarbonate.
• Treponema pallidum invades intercellular junctions of endothelial cell monolayers.
• Suppurative thrombophlebitis due to Aeromonas.
• Hypercoagulable states and venous thrombosis.
• Botulism associated with Clostridium botulinum sinusitis after intranasal cocaine abuse.
• Salmonella arizona infections associated with ingestion of rattlesnake capsules.
• Venous thromboembolic disease after hip surgery. Risk factors, prophylaxis, and diagnosis.
• Complement activation limits the rate of in vitro treponemicidal activity and correlates with antibody-mediated aggregation of Treponema pallidum rare outer membrane p...
• Early treatment with acyclovir for varicella pneumonia in otherwise healthy adults: retrospective controlled study and review.
• Changes in the surface of Leptospira interrogans serovar grippotyphosa during in vitro cultivation.
• Identification of Treponema pallidum subspecies pallidum genes encoding signal peptides and membrane-spanning sequences using a novel alkaline phosphatase expression v...
• Spirochaetal lipoproteins and pathogenesis.
• The leptospiral major outer membrane protein LipL32 is a lipoprotein expressed during mammalian infection.
• Leptospiral outer membrane proteins OmpL1 and LipL41 exhibit synergistic immunoprotection.
• Expression and distribution of leptospiral outer membrane components during renal infection of hamsters.
• Characterization of leptospiral outer membrane lipoprotein LipL36: downregulation associated with late-log-phase growth and mammalian infection.
• Heat shock response and groEL sequence of Bartonella henselae and Bartonella quintana.
• Molecular cloning and sequence analysis of the gene encoding LipL41, a surface-exposed lipoprotein of pathogenic Leptospira species.
• Molecular cloning and sequence analysis of the gene encoding OmpL1, a transmembrane outer membrane protein of pathogenic Leptospira spp.
• Use of the "blue halo" assay in the identification of genes encoding exported proteins with cleavable signal peptides: cloning of a Borrelia burgdorferi plasmid gene w...
• [Alignment of DNA sequences of ompL1 genes of insert fragment of recombinant plasmid, pDC38 of L. interrogans serovar lai and L. kirschneri].
• Genome features of Leptospira interrogans serovar Copenhageni.
• Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis.
• Immunohistochemical identification and pathologic findings in natural cases of equine abortion caused by leptospiral infection.
• Evaluation of recombinant Leptospira antigen-based enzyme-linked immunosorbent assays for the serodiagnosis of leptospirosis.
• Leptospiral proteins recognized during the humoral immune response to leptospirosis in humans.
• Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.
• Immuno-fluorescence assay of leptospiral surface-exposed proteins.
• [Expression in Escherichia coli of the gspd(l) gene of the type II secretion system in Leptospira borgpetersenii serovariety hardjo].

Schools

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• New York University

• UCLA Hospital

• University Of California Los Angeles

Doctors Specialties

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• Infectious Disease Medicine
• Infectious Disease

Accepted Insurances

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• CHAMPVA
• Commercial Insurance Company
• GEHA
• Medicare MCR
• United Healthcare

Education

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• UCLA Medical Center
• NYU School of Medicine

Hospital

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• Cedars-Sinai Medical Center
• LAC-Olive View-UCLA Medical Center
• Ronald Reagan UCLA Medical Center

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