Professor of Medicine, Beth Israel Deaconess Medical Center
Endocrinology
Dr. Bradford B. Lowell, MD
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Bradford B. Lowell works in the field of Endocrinology. Bradford Lowell is a published doctor as well. He has 100 publications published. The latest was: Adipose tissue lipoprotein lipase activity in rats with obesity-inducing hypothalamic knife cuts.
Publications
- Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress.
- NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.
- The hypothalamus.
- Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation.
- Identification of spinal circuits transmitting and gating mechanical pain.
- MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus.
- Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia.
- Leptin-Responsive GABAergic Neurons Regulate Fertility through Pathways That Result in Reduced Kisspeptinergic Tone.
- An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.
- Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP.
- Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin.
- ROCK1 in AgRP neurons regulates energy expenditure and locomotor activity in male mice.
- Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons.
- Runx1 Controls Terminal Morphology and Mechanosensitivity of VGLUT3-expressing C-Mechanoreceptors.
- GABAergic RIP-Cre Neurons in the Arcuate Nucleus Selectively Regulate Energy Expenditure.
- Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling.
- Recurrent network activity drives striatal synaptogenesis.
- Neuron-type-specific signals for reward and punishment in the ventral tegmental area.
- Presynaptic Inhibition of Gamma-Aminobutyric Acid Release in the Bed Nucleus of the Stria Terminalis by Kappa Opioid Receptor Signaling.
- Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons.
- High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons.
- Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice.
- Rapid, reversible activation of AgRP neurons drives feeding behavior in mice.
- Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis.
- Cholinergic Interneurons Mediate Fast VGluT3-Dependent Glutamatergic Transmission in the Striatum.
- Brainstem and Spinal Cord Circuitry Regulating REM Sleep and Muscle Atonia.
- 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.
- VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch.
- A serotonin and melanocortin circuit mediates D-fenfluramine anorexia.
- Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis.
- PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis.
- Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake.
- Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.
- Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protei...
- Monitoring FoxO1 localization in chemically identified neurons.
- 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis.
- Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight.
- Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance.
- Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.
- Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion.
- Dual role of proapoptotic BAD in insulin secretion and beta cell survival.
- EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses.
- Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network.
- Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.
- Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.
- Serotonin reciprocally regulates melanocortin neurons to modulate food intake.
- Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets.
- Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis.
- Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis.
- Mice lacking ghrelin receptors resist the development of diet-induced obesity.
- Divergence of melanocortin pathways in the control of food intake and energy expenditure.
- Mitochondrial dysfunction and type 2 diabetes.
- The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity.
- Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.
- Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.
- Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis.
- Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.
- Beta-Adrenergic receptors, diet-induced thermogenesis, and obesity.
- Suppression of beta cell energy metabolism and insulin release by PGC-1alpha.
- Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging.
- Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet.
- Adipose tissue mass can be regulated through the vasculature.
- betaAR signaling required for diet-induced thermogenesis and obesity resistance.
- Atypical beta-adrenergic effects on insulin signaling and action in beta(3)-adrenoceptor-deficient brown adipocytes.
- Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2.
- A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2.
- The mitochondrial uncoupling-protein homologues.
- Characterization of a novel ghrelin cell reporter mouse.
- PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling.
- Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.
- Thyroid hormones directly activate the expression of the human and mouse uncoupling protein-3 genes through a thyroid response element in the proximal promoter region.
- BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.
- Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres.
- Human alpha 2A-adrenergic receptor gene expressed in transgenic mouse adipose tissue under the control of its regulatory elements.
- Chimeric proteins between UCP1 and UCP3: the middle third of UCP1 is necessary and sufficient for activation by fatty acids.
- Frataxin activates mitochondrial energy conversion and oxidative phosphorylation.
- Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.
- Mouse melanocortin-4 receptor gene 5''-flanking region imparts cell specific expression in vitro.
- Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.
- Assessment of uncoupling activity of the human uncoupling protein 3 short form and three mutants of the uncoupling protein gene using a yeast heterologous expression s...
- Role of the beta(3)-adrenergic receptor and/or a putative beta(4)-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated re...
- Uncoupling protein-3 (UCP3): a mitochondrial carrier in search of a function.
- The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis.
- PPARgamma: an essential regulator of adipogenesis and modulator of fat cell function.
- beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes.
- Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart.
- Energy metabolism in uncoupling protein 3 gene knockout mice.
- Towards a molecular understanding of adaptive thermogenesis.
- Beta3 receptors mediate relaxation in stomach fundus whereas a fourth beta receptor mediates tachycardia in atria from transgenic beta3 receptor knockout mice.
- Uncoupling proteins 1 and 3 are regulated differently.
- Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.
- Adipose tissue lipoprotein lipase activity in rats with obesity-inducing hypothalamic knife cuts.
- Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.
- Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity.
- In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism.
- Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism.
- Cloning and functional characterization of an uncoupling protein homolog in hummingbirds.
- Non-effect of Massachusetts cement kiln dust upon the food intake, body weight, or activity of female rats.
- Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue.
Schools
Boston University School Of Medicine
Doctors Specialties
- Internal Medicine
- Endocrinology
Accepted Insurances
Hospital
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Beth Israel Deaconess Medical Center
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