Professor, Medicine, UCLA School of Medicine

Nephrology

Leon G. Fine, MB CHB

Leon Fine practices Nephrology. Leon G. Fine, MB CHB is also a published MD. He has 101 paper published. The most recent paper is: A study of the intrarenal recycling of urea in the rat with chronic experimental pyelonephritis.

Publications

Ernest Henry Starling (1866-1927) on the Glomerular and Tubular Functions of the Kidney.
Ernest Henry Starling (1866-1927) on the Formation and Reabsorption of Lymph.
A 2000-year history of nephrology: 10 enduring scientific landmarks.
Limitations of BOLD-MRI for assessment of hypoxia in chronically diseased human kidneys.
First heal thyself: rescue of dysfunctional endothelial progenitor cells restores function to the injured kidney.
Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics.
The response to loss of function of one kidney: it all depends upon what is happening next door.
Retinoids in nephrology: promises and pitfalls.
The clinical-skills examination.
Cellular defense against H2O2-induced apoptosis via MAP kinase-MKP-1 pathway.
Transcriptional induction of mitogen-activated protein kinase phosphatase 1 by retinoids. Selective roles of nuclear receptors and contribution to the antiapoptotic ef...
The breathing kidney.
Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia.
Progressive renal disease: the chronic hypoxia hypothesis.
Pexicrine effects of basement membrane components on paracrine signaling by renal tubular cells.
Hypoxia stimulates proximal tubular cell matrix production via a TGF-beta1-independent mechanism.
Transfer of a mutated gene encoding active transforming growth factor-beta 1 suppresses mitogenesis and IL-1 response in the glomerulus.
Mesangial cell-derived transforming growth factor-beta 1 reduces macrophage adhesiveness with consequent deactivation.
In vivo transfer of engineered macrophages into the glomerulus: endogenous TGF-beta-mediated defense against macrophage-induced glomerular cell activation.
Fibroblasts of rabbit kidney in culture. II. Paracrine stimulation of papillary fibroblasts by PDGF.
Hypoxia-induced changes in extracellular matrix metabolism in renal cells.
Progressive renal disease: fibroblasts, extracellular matrix, and integrins.
Cell-cell cross-talk in the pathogenesis of renal interstitial fibrosis.
Renal growth responses to acute and chronic injury: routes to therapeutic intervention.
Mechanisms of tubulo-interstitial injury in progressive renal diseases.
Patterns of mRNA expression during early cell growth differ in kidney epithelial cells destined to undergo compensatory hypertrophy versus regenerative hyperplasia.
Primary response gene expression in renal hypertrophy and hyperplasia: evidence for different growth initiation processes.
The concept of glomerular self-defense.
Gene transfer into the rat renal glomerulus via a mesangial cell vector: site-specific delivery, in situ amplification, and sustained expression of an exogenous gene i...
Transforming growth factor-beta 1 is the predominant paracrine inhibitor of macrophage cytokine synthesis produced by glomerular mesangial cells .
Gene delivery into the renal glomerulus by transfer of genetically engineered, autologous mesangial cells.
Gene transfer into the adult kidney for unravelling disease processes.
Loss of glomerular function and tubulointerstitial fibrosis: cause or effect?
An endothelin-1 mediated autocrine growth loop involved in human renal tubular regeneration.
Evidence for TGF-beta-mediated ''defense'' of the glomerulus: a blackguard molecule rehabilitated?
Evolving role of growth factors in the renal response to acute and chronic disease.
John Blackall (1771-1860): failure to see the obvious in dropsical patients with coagulable urine?
Stimulation of Na+/H+ exchange is not required for induction of hypertrophy of renal cells in vitro.
Hypertrophy of renal mitochondria.
Delayed branching of endothelial capillary-like cords in glycated collagen I is mediated by early induction of PAI-1.
Fibroblasts of rabbit kidney in culture. I. Characterization and identification of cell-specific markers.
Gene transfer into the kidney: promises and limitations.
Genetic manipulation of the kidney.
Tubular-derived growth factors and cytokines in the pathogenesis of tubulointerstitial fibrosis: implications for human renal disease progression.
British contributions to renal physiology: Of dynasties and diuresis.
Human tubular-derived endothelin in the paracrine regulation of renal interstitial fibroblast function.
Enhanced end-organ responsiveness of the uremic kidney to the natriuretic factor.
William Bowman''s description of the microscopic anatomy of the kidney.
The biology of renal hypertrophy.
Genetically engineered kidneys.
Pathological specimens of the kidney examined by Richard Bright.
Creation of a functioning chimeric mammalian kidney.
Gene transfer into the mammalian kidney: first steps towards renal gene therapy.
Gene transfer into the mammalian kidney: direct retrovirus-transduction of regenerating tubular epithelial cells.
Unravelling dropsy: from Marcello Malpighi''s discovery of the capillaries (1661) to Stephen Hales'' production of oedema in an experimental model (1733).
Gene transfer into the mammalian kidney: microtransplantation of retrovirus-transduced metanephric tissue.
Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros.
How little kidney tissue is enough?
A study of the intrarenal recycling of urea in the rat with chronic experimental pyelonephritis.
Epidermal growth factor accelerates functional recovery from ischaemic acute tubular necrosis in the rat: role of the epidermal growth factor receptor.
Cellular events in renal hypertrophy.
High levels of mRNA coding for substance P, somatostatin and alpha-tubulin are expressed by rat and rabbit dorsal root ganglia neurons.
EGF-induced mitogenesis in proximal tubular cells: potentiation by angiotensin II.
Gene therapy for human renal disease? Don't catch your zinc finger in your leucine zipper.
Inference of the existence of high blood pressure as a cause of renal disease in the mid-19th century: observations on vascular structures in the kidney.
Caveolar cohabitation.
Gene transfer into the kidney: promise for unravelling disease mechanisms, limitations for human gene therapy.
In vivo "culture" of a transporting renal epithelial monolayer.
Adaptation of renal tubule in uremia.
Functional profile of the isolated uremic nephron: intrinsic adaptation of phosphate transport in the rabbit proximal tubule.
Absence of direct effects of prostaglandins on sodium chloride transport in the mammalian nephron.
Effects of vasopressin on the isolated perfused human collecting tubule.
Preventing the progression of human renal disease: have rational therapeutic principles emerged?
Henry Bence Jones (1813-1873): on the influence of diet on urine composition. Including a previously unpublished treatise on the subject and a bibliography of his writ...
Natriuretic factor, a lasting enigma.
Uremia: formulations and expectations. The trade-off hypothesis: current status.
Integration of new embryonic nephrons into the kidney.
pH gradient-dependent increased Na+-H+ antiport capacity of the rabbit remnant kidney.
"Magnification phenomenon" in chronic renal disease.
Acute renal failure due to nephrotoxins.
William Bowman''s description of the glomerulus.
Influence of prostaglandins on sodium transport of isolated medullary nephron segments.
Glutathione-S-transferase activity in the rabbit nephron: segmental localization in isolated tubules and formation of thiol adducts of ethacrynic acid.
The uremic syndrome: adaptive mechanisms and therapy.
The role of nutrition in hypertrophy of renal tissue.
Molecular events in the organization of renal tubular epithelium: from nephrogenesis to regeneration.
Growth factors in the pathogenesis of renovascular complications of diabetes mellitus.
On the influence of the natriuretic factor from patients with chronic uremia on the bioelectric properties and sodium transport of the isolated mammalian collecting tu...
Letter: Split-renal-function analysis without ureteral catheterization in renovascular hypertension.
Hypertrophy of basolateral Na-K pump activity in the proximal tubule of the remnant kidney.
[3H]Ethylpropylamiloride, a ligand to analyze the properties of the Na+/H+ exchange system in the membranes of normal and hypertrophied kidneys.
Do glomerular hemodynamic adaptations influence the progression of human renal disease?
Acquired prostaglandin E2 (medullin) deficiency as the cause of oliguria in acute tubular necrosis. A hypothesis.
Clinical experience of UK medical students.
Restoring the Function of a Diseased Kidney via Its Microvasculature.
Samuel Johnson''s illnesses.
Intrarenal oxygenation in chronic renal failure.
Primary aldosteronism: renal effects compared with primary hypertension.
Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus.
How to evaluate and improve the quality and credibility of an outcomes database: validation and feedback study on the UK Cardiac Surgery Experience.

Doctors Specialties

Nephrology

Accepted Insurances

Education

University of Cape Town Faculty of Medicine

Hospital

Ronald Reagan UCLA Medical Center
Cedars-Sinai Medical Center

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