Academic practice
Internal Medicine
Dr. Yun Yen, MD
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is an expert in the field of Internal Medicine. He went to Taipei Medical College. He received awards:"America's Top Doctors", "Top Doctors:LA Area", "America's Top Doctors for Cancer", "Top Doctors:Southern California" and "Super Doctor". Yun Yen has written publications. He has 35 publications published with PubMed. The lastest publication is: 'A phase I pharmacodynamic study of GTI-2040, an antisense oligonucleotide against ribonuclotide reductase, in acute leukemias: a California Cancer Consortium study.'
Publications
- Primary Cutaneous Anaplastic Large Cell Lymphoma With Positive ALK Expression and a Rapidly Progressive Cutaneous Nodule.
- Expression of Glypican 3 Enriches Hepatocellular Carcinoma Development Related Genes and Associates with Carcinogenesis in Cirrhotic Livers.
- Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy.
- Reciprocal regulation of autophagy and dNTP pools in human Cancer cells.
- Tumor suppressor FOXO3 regulates ribonucleotide reductase subunit RRM2B and impacts on survival of Cancer patients.
- A germline missense mutation in COQ6 is associated with susceptibility to familial schwannomatosis.
- Pharmacodynamic and pharmacogenomic study of the nanoparticle conjugate of camptothecin CRLX101 for the treatment of Cancer.
- Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis.
- A distinct metabolic signature of human colorectal Cancer with prognostic potential.
- Identification of a distinct Small cell population from human bone marrow reveals its multipotency in vivo and in vitro.
- A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits Cancer cell growth and overcomes drug resistance.
- Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle.
- miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis.
- MicroRNA-657 promotes tumorigenesis in hepatocellular Carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways.
- Ribonucleotide reductase small subunit M2 serves as a prognostic biomarker and predicts poor survival of colorectal Cancers.
- Chromosomal Instability Triggered by Rrm2b Loss Leads to IL-6 Secretion and Plasmacytic Neoplasms.
- First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor Malignancies.
- RRM2B Suppresses Activation of the Oxidative Stress Pathway and is Up-regulated by P53 During Senescence.
- Secreted Protein Acidic and Rich in Cysteines-like 1 Suppresses Aggressiveness and Predicts Better Survival in Colorectal Cancers.
- Preclinical study of the cyclodextrin-polymer conjugate of camptothecin CRLX101 for the treatment of gastric Cancer.
- Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression.
- ROS1 as a 'druggable' receptor tyrosine kinase: lessons learned from inhibiting the ALK pathway.
- Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-ĸB signaling, and synergizes with an ERK i...
- Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA.
- HP1β Is a Biomarker for Breast Cancer Prognosis and PARP Inhibitor Therapy.
- Curative use of forequarter amputation for recurrent Breast cancer over an axillary area: a case report and literature review.
- The role of peroxiredoxin II in chemoresistance of Breast cancer cells.
- Jejunal Cancer with WRN Mutation Identified from Next-Generation Sequencing: A Case Study and Minireview.
- Arginine Starvation Impairs Mitochondrial Respiratory Function in ASS1-Deficient Breast Cancer Cells.
- Wnt modulates MCL1 to control cell survival in triple negative Breast cancer.
- Expression of DNA Translesion Synthesis Polymerase η in Head and Neck Squamous Cell Cancer Predicts Resistance to Gemcitabine and Cisplatin-Based Chemotherapy.
- Ribonucleotide reductase large subunit m1 predicts poor survival due to modulation of proliferative and invasive ability of gastric Cancer.
- Mass spectrometry-based quantitative metabolomics revealed a distinct lipid profile in Breast cancer patients.
- A phase I pharmacodynamic study of GTI-2040, an antisense oligonucleotide against ribonuclotide reductase, in Acute leukemias: a California Cancer Consortium study.
Schools
Taipei Medical University
St LukeS Hospital
Temple University Hospital
Yale University School Of Medicine
Conditions Treated
- Acute Leukemia
- Anemia
- Breast Cancer
- Carcinoma in Situ
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Doctors Specialties
- Medical Oncology
- Internal Medicine
Accepted Insurances
Awards
- America's Top Doctors
- Top Doctors:LA Area
- America's Top Doctors for Cancer
- Top Doctors:Southern California
- Super Doctor
Education
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Yale-New Haven Hospital -
Taipei Medical College
Hospital
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City of Hope's Helford Clinical Research Hospital
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