Assistant Professor, Medicine-Brigham and Women's Hospital, Harvard Medical School

Gastroenterology

Wolfram Goessling is an expert in the field of Gastroenterology. Dr. Wolfram Goessling has written publications. He has 50 publications published with PubMed. The lastest publication is: 'Intracellular transport of small hydrophobic compounds by the hepatocyte.'

Publications

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• Zebrafish: An Important Tool for Liver Disease Research.
• Repairing quite swimmingly: advances in regenerative medicine using zebrafish.
• Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche.
• Sequencing of LRP2 Reveals Multiple Rare Variants Associated with Urinary Trefoil Factor-3.
• Prostaglandin E2 Regulates Liver versus Pancreas Cell-Fate Decisions and Endodermal Outgrowth.
• Regenerative biology: Take the brakes off for Liver repair.
• S-Nitrosothiol Signaling Regulates Liver Development and Improves Outcome following Toxic Liver Injury.
• Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish.
• Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.
• Identification of small molecules for human hepatocyte expansion and iPS differentiation.
• Functional validation of GWAS gene candidates for abnormal Liver function during zebrafish Liver development.
• Multicenter Phase II Study of Tivozanib (AV-951) and Everolimus (RAD001) for Patients With Refractory, Metastatic ColoRectal Cancer.
• Glucose metabolism impacts the spatio-temporal onset and magnitude of HSC inDuction in vivo.
• Mutation mapping and identification by whole-genome sequencing.
• SCF(β-TRCP) suppresses angiogenesis and thyroid Cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.
• Genome-wide association study identifies loci influencing concentrations of Liver enzymes in plasma.
• Hematopoietic stem cell development: using the zebrafish to identify the signaling networks and physical forces regulating hematopoiesis.
• Genetic association for renal traits among participants of African ancestry reveals new loci for renal function.
• Deficiency of the Cytoskeletal Protein SPECC1L Leads to Oblique Facial Clefting.
• Endoderm specification, Liver development, and regeneration.
• Prostaglandin e2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models.
• PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury.
• The Wnt/beta-catenin pathway is required for the development of Leukemia stem cells in AML.
• Previews. NOTCHing an arrow at cord blood: translating stem cell knowledge into clinical practice.
• PTGER2 overexpression in coloRectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.
• Deciphering hepatocellular carcinoma: from bench to bedside and back.
• Topoisomerase II alpha is required for embryonic development and Liver regeneration in zebrafish.
• Hematopoietic stem cell development is dependent on blood flow.
• Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration.
• Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular Disease.
• Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling.
• APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in Liver development.
• Transparent adult zebrafish as a tool for in vivo transplantation Analysis.
• Ultrasound biomicroscopy permits in vivo characterization of zebrafish Liver tumors.
• Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.
• New waves of discovery: modeling Cancer in zebrafish.
• Effects of RAS on the genesis of embryonal rhabdomyosarcoma.
• Systemic treatment of patients who have coloRectal cancer and inflammatory bowel disease.
• Increased Liver chemistry in an asymptomatic patient.
• Localization of bilirubin in phospholipid bilayers by parallax Analysis of fluorescence quenching.
• Role of apolipoprotein D in the transport of bilirubin in plasma.
• Mechanism of hepatocellular uptake of albumin-bound bilirubin.
• Unconjugated bilirubin exhibits spontaneous diffusion through model lipid bilayers and native hepatocyte membranes.
• Intracellular transport of small hydrophobic compounds by the hepatocyte.
• Influence of glutathione S-transferase B (ligandin) on the intermembrane transfer of bilirubin. Implications for the intracellular transport of nonsubstrate ligands in...
• Kinetics of bilirubin transfer between serum albumin and membrane vesicles. Insight into the mechanism of organic anion deLivery to the hepatocyte plasma membrane.
• Membrane lipid composition and vesicle size modulate bilirubin intermembrane transfer. Evidence for membrane-directed trafficking of bilirubin in the hepatocyte.
• Cannabinoid receptor signaling regulates Liver development and metabolism.
• Hypoxia as a therapy for mitochondrial Disease.

Schools

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• Witten Herdecke University Faculty Of Med

• Brigham and Women39s Hospital

• Dana Farber Cancer Institute

• Massachusetts General Hospital

Procedures Preformed

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• Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
• Endoscopy (Esophagus, Stomach, Small Intestine)

Conditions Treated

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• Abdominal Pain
• Acute Leukemia
• Anal and Rectal Cancer
• Anemia
• View All

Doctors Specialties

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• Gastroenterology
• Medical Oncology
• Oncology

Accepted Insurances

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• Aetna HMO
• Choice Plus POS II
• Blue Card PPO
• BlueConnect HMO
• Blue with Managed Care Behavioral Health HMO
• Preferred Blue PPO
• Cigna HMO
• Cigna PPO
• Great West Healthcare-Cigna PPO
• Open Access Plus
• First Health (Coventry Health Care) PPO
• Medicare Advantage PFFS
• Choice Care PPO
• Medicare MCR
• MultiPlan PPO
• PHCS Network PPO
• National Elevator
• Principal Life
• Tufts Health Plans
• Tufts PPO
• Choice Plus POS
• Navigate HMO
• Navigate POS
• Options PPO
• United Healthcare

Education

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• Massachusetts General Hospital
• Brigham and Women's Hospital

Hospital

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• Brigham and Women's Hospital
• Dana-Farber Cancer Institute

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