Professor, Biochemistry and Molecular Biology, St Louis University School of Medicine

Internal Medicine

Dr. William S. Sly is an expert in the field of Internal Medicine. He attended Saint Louis University School of Medicine. Saint Louis University School of Medicine is ranked 67/57 in Research/PrimaryCare. He received awards:"Elected Member". William is a published physician as well. He has 11 publications published. The latest was: Clinical course of sly syndrome (mucopolysaccharidosis type VII).

Publications

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• Clinical course of sly syndrome (mucopolysaccharidosis type VII).
• First human treatment with investigational rhGUS enzyme replacement therapy in an advanced stage MPS VII patient.
• Enzyme replacement therapy in newborn mucopolysaccharidosis IVA mice: Early treatment rescues bone lesions?
• The final frontier - crossing the blood-brain barrier.
• Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism.
• Assessment of bone dysplasia by micro-CT and glycosaminoglycan levels in mouse models for mucopolysaccharidosis type I, IIIA, IVA, and VII.
• Effect of sulfonamides as carbonic anhydrase VA and VB inhibitors on mitochondrial metabolic energy conversion.
• Alpha Adrenergic Induction of Transport of Lysosomal Enzyme across the Blood-Brain Barrier.
• High Resolution Crystal Structure of Human β-Glucuronidase Reveals Structural Basis of Lysosome Targeting.
• Membrane Associated Carbonic Anhydrase IV (CA IV): A Personal and Historical Perspective.

Schools

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• Saint Louis University School of Medicine

Doctors Specialties

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• Other
• Internal Medicine

Accepted Insurances

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Awards

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• Elected Member

Education

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• National Institutes of Health Clinical Center
• Washington University - Barnes-Jewish Hospital
• Saint Louis University School of Medicine

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