Professor, Biochemistry and Molecular Biology, Oregon Health and Science University School of Medicine
Hematology
Dr. William R. Skach, MD
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Dr. William R. Skach practices Hematology. He went to Harvard Medical School. Harvard Medical School is a top medical college. Harvard Medical School has a rank of 1 in research and a 12 in primary care He has 1 awards "Elected Member". William R. Skach is a published physician. He published 76 publications, including: 'Evidence that endoplasmic reticulum (ER)-associated degradation of cystic fibrosis transmembrane conductance regulator is linked to retrograde translocation from the E...'
Publications
- Cotranslational Stabilization of Sec62/63 within the ER Sec61 Translocon Is Controlled by Distinct Substrate-Driven Translocation Events.
- Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex.
- Endoplasmic Reticulum Protein Quality Control Is Determined by Cooperative Interactions between Hsp/c70 Protein and the CHIP E3 Ligase.
- Thermal instability of ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) channel function: protection by single suppressor mutations and inhibiting chan...
- Kinetic analysis of Ribosome-bound fluorescent proteins reveals an early, stable, cotranslational folding intermediate.
- Epstein-Barr viral BNLF2a Hijacks the tail-anchored protein insertion machinery to block antigen processing by the TAP complex.
- Stepwise Insertion and Inversion of a Type II Signal Anchor Sequence in the Ribosome-Sec61 Translocon Complex.
- The cytoplasmic domain of Rhesus cytomegalovirus Rh178 interrupts translation of MHC-I leader peptide-containing proteins prior to translocation.
- Role of Hsc70 Binding Cycle in CFTR Folding and Endoplasmic Reticulum Associated-Degradation.
- Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems.
- Ligand-driven vectorial folding of ribosome-bound human CFTR NBD1.
- N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2.
- In Vitro Methods for CFTR Biogenesis.
- CFTR Folding Consortium: Methods Available for Studies of CFTR Folding and Correction.
- In vitro incorporation of nonnatural amino acids into protein using tRNA(Cys)-derived opal, ochre, and amber suppressor tRNAs.
- Role of Hsp90 in biogenesis of the beta-cell ATP-sensitive potassium channel complex.
- Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.
- Cellular mechanisms of membrane protein folding.
- Sequence-specific retention and regulated integration of a nascent membrane protein by the endoplasmic reticulum Sec61 translocon.
- Aquaporin-4 dynamics in orthogonal arrays in live cells visualized by quantum dot single particle tracking.
- Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome.
- The expanding role of the ER translocon in membrane protein folding.
- A novel tripartite motif involved in aquaporin topogenesis, monomer folding and tetramerization.
- Real-time fluorescence detection of ERAD substrate retrotranslocation in a mammalian in vitro system.
- Global organization and function of mammalian cytosolic proteasome pools: Implications for PA28 and 19S regulatory complexes.
- CFTR: new members join the fold.
- Aberrant folding of a mutant Stat5b causes growth hormone insensitivity and proteasomal dysfunction.
- An energy-dependent maturation step is required for release of the cystic fibrosis transmembrane conductance regulator from early endoplasmic reticulum biosynthetic ma...
- Sequential triage of transmembrane segments by Sec61alpha during biogenesis of a native multispanning membrane protein.
- The cotranslational contacts between ribosome-bound nascent polypeptides and the subunits of the hetero-oligomeric chaperonin TRiC probed by photocross-linking.
- Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits.
- Differential stability of biogenesis intermediates reveals a common pathway for aquaporin-1 topological maturation.
- Reticulocyte lysate as a model system to study endoplasmic reticulum membrane protein degradation.
- Evidence for stabilization of aquaporin-2 folding mutants by N-linked glycosylation in endoplasmic reticulum.
- Cooperativity and flexibility of cystic fibrosis transmembrane conductance regulator transmembrane segments participate in membrane localization of a charged residue.
- In vitro reconstitution of CFTR biogenesis and degradation.
- Redundancy of mammalian proteasome beta subunit function during endoplasmic reticulum associated degradation.
- A 76-bp deletion in the Mip gene causes autosomal dominant cataract in Hfi mice.
- Reorientation of aquaporin-1 topology during maturation in the endoplasmic reticulum.
- Identification of sequence determinants that direct different intracellular folding pathways for aquaporin-1 and aquaporin-4.
- Novel mutations in 13 probands with galactokinase deficiency.
- Defects in processing and trafficking of the cystic fibrosis transmembrane conductance regulator.
- Transmembrane biogenesis of Kv1.3.
- Evidence that endoplasmic reticulum (ER)-associated degradation of cystic fibrosis transmembrane conductance regulator is linked to retrograde translocation from the E...
- Cystic fibrosis transmembrane conductance regulator-associated ATP release is controlled by a chloride sensor.
- Coupled translocation events generate topological heterogeneity at the endoplasmic reticulum membrane.
- Topology of P-glycoproteins.
- Co- and posttranslational translocation mechanisms direct cystic fibrosis transmembrane conductance regulator N terminus transmembrane assembly.
- Evidence for interaction between transmembrane segments in assembly of Kv1.3.
- Structural cues involved in endoplasmic reticulum degradation of G85E and G91R mutant cystic fibrosis transmembrane conductance regulator.
- Identification of a cDNA for Ca++-independent phospholipase A2 of lung lamellar bodies/lysosomes.
- Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein.
- Fine structure of the human galactokinase GALK1 gene.
- Water transport across mammalian cell membranes.
- Voltage-gated K+ channels contain multiple intersubunit association sites.
- Structure and function of kidney water channels.
- Cloning, functional analysis and cell localization of a kidney proximal tubule water transporter homologous to CHIP28.
- Evidence for an alternate model of human P-glycoprotein structure and biogenesis.
- Transmembrane orientation and topogenesis of the third and fourth membrane-spanning regions of human P-glycoprotein (MDR1).
- Amino-terminal assembly of human P-glycoprotein at the endoplasmic reticulum is directed by cooperative actions of two internal sequences.
- Mechanism of inhibition of cAMP-dependent epithelial chloride secretion by phorbol esters.
- Distinct biogenesis mechanisms for the water channels MIWC and CHIP28 at the endoplasmic reticulum.
- Radiotracer studies of cystic fibrosis transmembrane conductance regulator expressed in Xenopus oocytes.
- Biogenesis and transmembrane topology of the CHIP28 water channel at the endoplasmic reticulum.
- Functional independence of monomeric CHIP28 water channels revealed by expression of wild-type mutant heterodimers.
- Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues.
- Expression, functional analysis, and in situ hybridization of a cloned rat kidney collecting duct water channel.
- Cloning of a novel rat kidney cDNA homologous to CHIP28 and WCH-CD water channels.
- A multifunctional aqueous channel formed by CFTR.
- p97 functions as an auxiliary factor to facilitate TM domain extraction during CFTR ER-associated degradation.
- Molecular mechanisms of aquaporin biogenesis by the endoplasmic reticulum Sec61 translocon.
- Uncoupling proteasome peptidase and ATPase activities results in cytosolic release of an ER polytopic protein.
- Molecular mechanism of P-glycoprotein assembly into cellular membranes.
- Biogenesis of CFTR and other polytopic membrane proteins: new roles for the ribosome-translocon complex.
- Pharmacological chaperoning: two ''hits'' are better than one.
Schools
Harvard Medical School
University Calif
Doctors Specialties
- Hematology
- Medical Oncology
- Oncology
Accepted Insurances
- Choice Plus POS II
- ODS Health Plan
Awards
- Elected Member
Education
-
UCSF -
Harvard Medical School
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