Professor, Medicine, University of Washington School of Medicine
Cardiology
Dr. William R. MacLellan, MD
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William MacLellan works in the field of Cardiology. He attended Baylor College of Medicine. He received awards:"Super Doctor" and "Fellow (FACC)". William MacLellan has written publications. He has 95 publications published with PubMed. The lastest paper is: 'Tumor necrosis factor-alpha is persistently expressed in cardiac allografts in the absence of histological or clinical evidence of rejection.' He is registered with Medicare.
Publications
- Outcomes of Biventricular Mechanical Support Patients Discharged to Home to Await Heart Transplantation.
- THY-1 Receptor Expression Differentiates Cardiosphere-Derived Cells with Divergent Cardiogenic Differentiation Potential.
- Microenvironment influences vascular differentiation of murine cardiovascular progenitor cells.
- Heart Failure is Associated With Impaired Anti-Inflammatory and Antioxidant Properties of High-Density Lipoproteins.
- Regeneration potential of adult cardiac myocytes.
- Divergent mitochondrial biogenesis responses in human Cardiomyopathy.
- Cardiopoietry in Motion: Primed Mesenchymal Stem Cells for Ischemic Cardiomyopathy.
- Epigenetic regulation of myogenic gene expression by heterochromatin protein 1 alpha.
- Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells.
- Risk stratification in patients with advanced Heart failure requiring biventricular assist device support as a bridge to cardiac transplantation.
- Hybrid coaxial electrospun nanofibrous scaffolds with limited immunological response created for tissue engineering.
- Hypoxic cell death is reduced by pH buffering in a model of engineered Heart tissue.
- Analysis of pH gradients resulting from mass transport limitations in engineered Heart tissue.
- Modulation of gene expression in neonatal rat cardiomyocytes by surface modification of polylactide-co-glycolide substrates.
- Epigenetic regulation of cardiac myocyte differentiation.
- Mithramycin Is a Gene-Selective Sp1 Inhibitor That Identifies a Biological Intersection between Cancer and Neurodegeneration.
- Induced pluripotent stem cells for regenerative cardiovascular therapies and biomedical discovery.
- Systems-based approaches to cardiovascular Disease.
- Statins do not significantly affect muscle sympathetic nerve activity in humans with nonischemic Heart failure: a double-blind placebo-controlled trial.
- Abcc6 deficiency causes increased infarct size and apoptosis in a mouse cardiac ischemia-reperfusion model.
- The role of E2F-1 and downstream target genes in mediating ischemia/reperfusion injury in vivo.
- Relative roles of Heart transplantation and long-term mechanical circulatory support in contemporary management of advanced Heart failure - a critical appraisal 10 yea...
- Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes.
- Proteomic insights into cardiac cell death and survival.
- Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells.
- Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice.
- Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's Syndrome-like exocrinopathy.
- Induced pluripotent stem cells: it's like déjàvu all over again.
- Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly.
- Adipose tissue-derived cells improve cardiac function following Myocardial infarction.
- Cyclin-dependent kinase 2 signaling regulates Myocardial ischemia/reperfusion injury.
- Deducing topology of protein-protein interaction networks from experimentally measured sub-networks.
- Altered proteome biology of cardiac mitochondria under stress conditions.
- Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages.
- Quantitative second harmonic generation imaging of cartilage damage.
- A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium.
- Feasibility and safety of autologous myoblast transplantation in patients with ischemic Cardiomyopathy.
- Cyclooxygenase products sensitize muscle mechanoreceptors in humans with Heart failure.
- Human adipose stem cells: a potential cell source for cardiovascular tissue engineering.
- Influence of systematically varied nano-scale topography on cell morphology and adhesion.
- The role of cytoprotective cytokines in cardiac ischemia/reperfusion injury.
- Atorvastatin and statins in the treatment of Heart failure.
- Effects of a home-based exercise program on clinical outcomes in Heart failure.
- Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren's Syndrome.
- Hypertrophy and Heart failure in mice overexpressing the cardiac sodium-calcium exchanger.
- Optimized preservation of extracellular matrix in cardiac tissues: implications for long-term graft durability.
- Cardiac myocyte cell cycle control in development, Disease, and regeneration.
- Collagen IV induces trophoectoderm differentiation of mouse embryonic stem cells.
- Analysis of oxygen transport in a diffusion-limited model of engineered Heart tissue.
- Fundamentals of stem cell mobilization for the heart: prospects for treating heart Disease.
- Hypertrophic growth in cardiac myocytes is mediated by Myc through a Cyclin D2-dependent pathway.
- Regulation of RNA polymerase III transcription during hypertrophic growth.
- Safety and feasibility of autologous myoblast transplantation in patients with ischemic Cardiomyopathy: four-year follow-up.
- Hysteresis and cell cycle transitions: how crucial is it?
- Heart disease leaves its mark: proteomics-based biosignatures in Acute coronary syndromes.
- Muscle mechanoreceptor sensitivity in Heart failure.
- Coordination of cell growth and cell division: a mathematical modeling study.
- Multisite phosphorylation and network dynamics of cyclin-dependent kinase signaling in the eukaryotic cell cycle.
- Statin therapy is associated with improved survival in ischemic and non-ischemic Heart failure.
- Dilated Cardiomyopathy: learning to live with yourself.
- Dynamics of the cell cycle: checkpoints, sizers, and timers.
- EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD.
- Cardiac troponin I is associated with impaired hemodynamics, progressive left ventricular dysfunction, and increased mortality rates in advanced Heart failure.
- Elevated serum levels of the CXCR3 chemokine ITAC are associated with the development of transplant Coronary artery disease.
- Acupuncture inhibits sympathetic activation during mental stress in advanced Heart failure patients.
- Low serum total cholesterol is associated with marked increase in mortality in advanced Heart failure.
- Regulation of the mammalian cell cycle: a model of the G1-to-S transition.
- Cardiomyocytes undergo apoptosis in human immunodeficiency virus Cardiomyopathy through mitochondrion- and death receptor-controlled pathways.
- Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced Heart failure.
- Inducible activation of c-Myc in adult myocardium in vivo provokes cardiac myocyte hypertrophy and reactivation of DNA synthesis.
- The relationship between obesity and mortality in patients with Heart failure.
- Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor.
- Cyclin-dependent kinase-2 in the birth and death of cardiac muscle cells.
- A novel Rb- and p300-binding protein inhibits transactivation by MyoD.
- Advances in the molecular mechanisms of Heart failure.
- Genetic dissection of cardiac growth control pathways.
- Tumor necrosis factor-alpha is persistently expressed in cardiac allografts in the absence of histological or clinical evidence of rejection.
- Success in Failure: modeling cardiac decompensation in transgenic mice.
- Cell cycle regulators in vascular Disease.
- Death by design. Programmed cell death in cardiovascular biology and Disease.
- Serum response factor mediates AP-1-dependent induction of the skeletal alpha-actin promoter in ventricular myocytes.
- Transforming growth factor-beta in cardiac ontogeny and adaptation.
- A dominant-negative receptor for type beta transforming growth factors created by deletion of the kinase domain.
- Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus.
- Transforming growth factor-beta response elements of the skeletal alpha-actin gene. Combinatorial action of serum response factor, YY1, and the SV40 enhancer-binding p...
- p21 Ras as a governor of global gene expression.
- Molecular approaches to cardiac development and hypertrophy.
- Control of cardiac gene transcription by fibroblast growth factors.
- Expression of cardiomyocytic markers on adipose tissue-derived cells in a murine model of Acute myocardial injury.
- Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus Heart-specific deletion of Rb.
- Recapitulation of the embryonic cardiovascular progenitor cell niche.
- Three-dimensional electrospun ECM-based hybrid scaffolds for cardiovascular tissue engineering.
- Cardiomyopathy is associated with structural remodelling of heart Valve extracellular matrix.
- The use of three-dimensional nanostructures to instruct cells to produce extracellular matrix for regenerative medicine strategies.
Schools
University Of Toronto College Of Medicine
University Toronto
Baylor College Of Med
Procedures Preformed
- Ablation for Treatment of Cardiac Arrhythmias
- Cardiac Catheterization (incl. Coronary Angiography)
- Cardiac Imaging
- Cardiac MRI (Magnetic Resonance Imaging) of Heart or Chest
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Conditions Treated
- Angina and Acute Coronary Syndrome
- Aortic Aneurysm
- Aortic Ectasia
- Aortic Valve Disease
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Doctors Specialties
- Cardiology
Accepted Insurances
Awards
- Super Doctor
- Fellow (FACC)
Education
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Baylor College of Medicine -
University of Toronto Faculty of Medicine
Drug Facts
| NPI NUMBER | 1427077320 | |
| NPPES Provider LastName | MACLELLAN | |
| NPPES Provider FirstName | WILLIAM | |
| NPPES Provider ZIPCode | 981956422 | |
| NPPES Provider State | WA | |
| Specialty Description | Cardiology | |
| Total Claim Count | 137.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1427077320 |
| Last Name Of The Provider | MACLELLAN |
| First Name Of The Provider | WILLIAM |
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