Physician
Emergency Medicine
Dr. William Kristan, MD
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Doctor William Kristan, MD practices Emergency Medicine. He graduated from University of Pittsburgh School of Medicine. He over the years received 2 awards: "Fellow (FACEP)" and "Top MD". Dr. William Kristan is a published doctor and has 100 publications published. The lastest was: 'Development of spontaneous and evoked behaviors in the medicinal leech.'
Publications
- Improved PeT Molecules for Optically Sensing Voltage in Neurons.
- NSF workshop report: Discovering general principles of nervous system organization by comparing brain maps across species.
- Vertebrate versus invertebrate neural circuits.
- Optical imaging of neuronal populations during decision-making.
- Development of neuronal circuits and behaviors in the medicinal leech.
- A central pattern generator underlies crawling in the medicinal leech.
- Kinematics and modeling of leech crawling: evidence for an oscillatory behavior produced by propagating waves of excitation.
- Dendritic Ca(2+)-activated K(+) conductances regulate electrical signal propagation in an invertebrate neuron.
- Relative roles of the S cell network and parallel interneuronal pathways in the whole-body shortening reflex of the medicinal leech.
- Identification of neural circuits by imaging coherent electrical activity with FRET-based dyes.
- Supralinear summation of synaptic inputs by an invertebrate neuron: dendritic gain is mediated by an "inward rectifier" K(+) current.
- Glial responses during evoked behaviors in the leech.
- He's got rhythm: single neurons signal timing on a scale of seconds.
- Development of spontaneous and evoked behaviors in the medicinal leech.
- Staging of middle and late embryonic development in the medicinal leech, Hirudo medicinalis.
- Representation of touch location by a population of leech sensory neurons.
- Long-lasting depolarization of leech neurons mediated by receptors with a nicotinic binding site.
- Behavioral hierarchy in the medicinal leech, Hirudo medicinalis: feeding as a dominant behavior.
- Population coding and behavioral choice.
- Quantitative analysis of a directed behavior in the medicinal leech: implications for organizing motor output.
- A neuronal network for computing population vectors in the leech.
- The neuronal basis of the behavioral choice between swimming and shortening in the leech: control is not selectively exercised at higher circuit levels.
- A model of the hydrostatic skeleton of the leech.
- Widespread mechanosensory activation of the serotonergic system of the medicinal leech.
- Mapping motor neurone activity to overt behaviour in the leech: internal pressures produced during locomotion.
- An increase in activity of serotonergic Retzius neurones may not be necessary for the consummatory phase of feeding in the leech Hirudo medicinalis.
- Mapping motor neuron activity to overt behavior in the leech. I. Passive biomechanical properties of the body wall.
- The whole-body shortening reflex of the medicinal leech: motor pattern, sensory basis, and interneuronal pathways.
- Developmental regulation of segment-specific cholinergic receptors on Retzius neurons in the medicinal leech.
- Cell-cell interactions that modulate neuronal development in the leech.
- Parallel pathways coordinate crawling in the medicinal leech, Hirudo medicinalis.
- Using reflexive behaviors of the medicinal leech to study information processing.
- Segment-specific modulation of the electrophysiological activity of leech Retzius neurons by acetylcholine.
- The dual role of serotonin in leech swimming.
- Distributed processing of sensory information in the leech. II. Identification of interneurons contributing to the local bending reflex.
- Distributed processing of sensory information in the leech. I. Input-output relations of the local bending reflex.
- Segmental specialization of neuronal connectivity in the leech.
- Two forms of sensitization of the local bending reflex of the medicinal leech.
- The oblique muscle organizer in Hirudo medicinalis, an identified embryonic cell projecting multiple parallel growth cones in an orderly array.
- Development of the leech nervous system.
- Mesenchyme of embryonic reproductive ducts directs process outgrowth of Retzius neurons in the medicinal leech.
- Analysis and modeling of the multisegmental coordination of shortening behavior in the medicinal leech. II. Role of identified interneurons.
- Analysis and modeling of the multisegmental coordination of shortening behavior in the medicinal leech. I. Motor output pattern.
- Neuronal basis of behavior.
- Monitoring neuronal activity during discrete behaviors: a crawling, swimming and shortening device for tethered leeches.
- Target influences on the development of leech neurons.
- Pepherial feedback in the leech swimming rhythm.
- Rhythmic swimming activity in neurones of the isolated nerve cord of the leech.
- Neuronal generation of the leech swimming movement.
- Neuronal changes related to behavioral changes in chronically isolated segments of the medicinal leech.
- Neurons controlling the initiation, generation and modulation of leech swimming.
- Identified GABAergic inhibitory motor neurons in the leech central nervous system take up GABA.
- Development of segmental differences in the pressure mechanosensory neurons of the leech Haementeria ghilianii.
- A kinematic study of crawling behavior in the leech, Hirudo medicinalis.
- Swim initiation in the leech by serotonin-containing interneurones, cells 21 and 61.
- Inhibitory connections between motor neurons modify a centrally generated motor pattern in the leech nervous system.
- Neural mechanisms generating the leech swimming rhythm: swim-initiator neurons excite the network of swim oscillator neurons.
- Segment-specific morphogenesis of leech Retzius neurons requires particular peripheral targets.
- Morphological changes in leech Retzius neurons after target contact during embryogenesis.
- An identified cell is required for the formation of a major nerve during embryogenesis in the leech.
- Multifunctional interneurons in behavioral circuits of the medicinal leech.
- Embryonic assembly of a complex muscle is directed by a single identified cell in the medicinal leech.
- Physiological and morphological analysis of synaptic transmission between leech motor neurons.
- Peripheral target choice by homologous neurons during embryogenesis of the medicinal leech. II. Innervation of ectopic reproductive tissue by nonreproductive Retzius c...
- Peripheral target choice by homologous neurons during embryogenesis of the medicinal leech. I. Segment-specific preferences of Retzius cells.
- Function of identified interneurons in the leech elucidated using neural networks trained by back-propagation.
- Central synaptic inputs to identified leech neurons determined by peripheral targets.
- Multifunctional pattern-generating circuits.
- Localization of a leech inhibitory synapse by photo-ablation of individual dendrites.
- Mapping of neuronal contacts with intracellular injection of horseradish peroxidase and Lucifer yellow in combination.
- Disruption of peripheral target contact influences the development of identified central dendritic branches in a leech motor neuron in vivo.
- Evidence for sequential decision making in the medicinal leech.
- Quantifying stimulus discriminability: a comparison of information theory and ideal observer analysis.
- Form and function in systems neuroscience.
- Encoding and decoding touch location in the leech CNS.
- Leech locomotion: swimming, crawling, and decisions.
- Photochemical control of endogenous ion channels and cellular excitability.
- Neuroscience. A push-me pull-you neural design.
- Neuronal decision-making circuits.
- A hormone-activated central pattern generator for courtship.
- Species-specific behavioral patterns correlate with differences in synaptic connections between homologous mechanosensory neurons.
- Behavioral choice by presynaptic inhibition of tactile sensory terminals.
- Optically monitoring voltage in neurons by photo-induced electron transfer through molecular wires.
- Decision-making in the leech nervous system.
- Contextual modulation of behavioral choice.
- Gap junction expression is required for normal chemical synapse formation.
- Alpha-conotoxin ImI disrupts central control of swimming in the medicinal leech.
- Feeding-mediated distention inhibits swimming in the medicinal leech.
- Behavioral choice across leech species: chacun àson goût.
- From synapses to behavior: development of a sensory-motor circuit in the leech.
- Imaging dedicated and multifunctional neural circuits generating distinct behaviors.
- Cellular substrates of action selection: a cluster of higher-order descending neurons shapes body posture and locomotion.
- Widespread inhibition proportional to excitation controls the gain of a leech behavioral circuit.
- Effects of anthropogenic developments on common raven nesting biology in the West Mojave Desert.
- From crawling to cognition: analyzing the dynamical interactions among populations of neurons.
- Functions of the subesophageal ganglion in the medicinal leech revealed by ablation of neuromeres in embryos.
- Neuronal control of leech behavior.
- Embryonic electrical connections appear to pre-figure a behavioral circuit in the leech CNS.
- Development of swimming in the medicinal leech, the gradual acquisition of a behavior.
Schools
University Of Pennsylvania School Of Medicine
Akron City Hospital
Mercy Hospital Pittsburgh
Doctors Specialties
- Emergency Medicine
Accepted Insurances
Awards
- Fellow (FACEP)
- Top MD
Education
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University of Pittsburgh Medical Center-Mercy Hospital -
University of Pittsburgh School of Medicine
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