Professor, Pharmacology, UMDNJ-Robert Wood Johnson Medical School
Otolaryngology (ENT)
Dr. William J. Welsh, MD
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William Welsh works in the field of Otolaryngology (ENT). He graduated from Medical College of Georgia. William Welsh is a published doctor. He published 100 publications, including: 'Three-dimensional quantitative structure-activity relationship study of the cannabimimetic (aminoalkyl)indoles using comparative molecular field analysis.'
Publications
- Micellar and structural stability of nanoscale amphiphilic polymers: Implications for anti-atherosclerotic bioactivity.
- Avalanche for shape and feature-based virtual screening with 3D alignment.
- Polyester monomers lack ability to bind and activate both androgenic and estrogenic receptors as determined by In Vitro and In Silico methods.
- Fragment-based Shape Signatures: a new tool for virtual screening and drug discovery.
- In silico design of anti-atherogenic biomaterials.
- Pregnane X Receptor Mediates Dyslipidemia Induced by the HIV Protease Inhibitor Amprenavir in Mice.
- Cardiovascular Outcomes and the Physical and Chemical Properties of Metal Ions Found in Particulate Matter Air Pollution: a QICAR Study.
- Bisphenol A and Its Analogs Activate Human Pregnane X Receptor.
- Identification of heparin samples that contain impurities or contaminants by chemometric pattern recognition analysis of proton NMR spectral data.
- Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information.
- Rapid discovery of inhibitors of Toxoplasma gondii using hybrid structure-based computational approach.
- Class modeling analysis of heparin 1H NMR spectral data using the soft independent modeling of class analogy and unequal class modeling techniques.
- Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum.
- Evolving carbapenemases: can medicinal chemists advance one step ahead of the coming storm?
- Application of screening methods, shape signatures and engineered biosensors in early drug discovery process.
- Predicting inhibitors of acetylcholinesterase by regression and classification machine learning approaches with combinations of molecular descriptors.
- The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation.
- Hybrid scoring and classification approaches to predict human pregnane X receptor activators.
- Novel microtubule polymerization inhibitor with potent antiproliferative and antitumor activity.
- Halogenated ligands and their interactions with amino acids: implications for structure-activity and structure-toxicity relationships.
- Computational discovery of novel low micromolar human pregnane X receptor antagonists.
- New predictive models for blood-brain barrier permeability of drug-like molecules.
- Evolution of the bile salt nuclear receptor FXR in vertebrates.
- Shape signatures: new descriptors for predicting cardiotoxicity in silico.
- Structural characterization of the zinc binding domain in cytosolic PSD-95 interactor (cypin): Role of zinc binding in guanine deamination and dendrite branching.
- Prediction of Fibrinogen Adsorption for Biodegradable Polymers: Integration of Molecular Dynamics and Surrogate Modeling.
- Volume learning algorithm significantly improved PLS model for predicting the estrogenic activity of xenoestrogens.
- Unique helical conformation of the fourth cytoplasmic loop of the CB1 cannabinoid receptor in a negatively charged environment.
- Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites.
- Highly potent triazole-based tubulin polymerization inhibitors.
- Identification of previously unrecognized antiestrogenic chemicals using a novel virtual screening approach.
- A preliminary in silico lead series of 2-phthalimidinoglutaric acid analogues designed as MMP-3 inhibitors.
- Wavelet analysis of DNA walks.
- Discovery of novel triazole-based opioid receptor antagonists.
- Highly predictive CoMFA and CoMSIA models for two series of stromelysin-1 (MMP-3) inhibitors elucidate S1' and S1-S2' binding modes.
- Structural model reveals key interactions in the assembly of the pregnane X receptor/corepressor complex.
- 3D-QSAR comparative molecular field analysis on delta opioid receptor agonist SNC80 and its analogs.
- Structural model of the Plasmodium CDK, Pfmrk, a novel target for malaria therapeutics.
- Rapid assessment of contact-dependent secondary structure propensity: relevance to amyloidogenic sequences.
- Prediction of the orientations of adsorbed protein using an empirical energy function with implicit solvation.
- Elucidation of the Na+, K+-ATPase digitalis binding site.
- Requirement of activated Cdc42-associated kinase for survival of v-Ras-transformed mammalian cells.
- 3D-QSAR comparative molecular field analysis on opioid receptor antagonists: pooling data from different studies.
- Enrichment of ligands for the serotonin receptor using the Shape Signatures approach.
- Detecting hidden sequence propensity for amyloid fibril formation.
- Using surrogate modeling in the prediction of fibrinogen adsorption onto polymer surfaces.
- Identification of possible kinetically significant anion-binding sites in human serum transferrin using molecular modeling strategies.
- Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).
- Characteristics of the Plasmodium falciparum PK5 ATP-binding site: implications for the design of novel antimalarial agents.
- Identification of a minimal subset of receptor conformations for improved multiple conformation docking and two-step scoring.
- Shape signatures: a new approach to computer-aided ligand- and receptor-based drug design.
- Computational models for predicting the binding affinities of ligands for the wild-type androgen receptor and a mutated variant associated with human prostate Cancer.
- Fractal fingerprinting of chromatographic profiles based on wavelet analysis and its application to characterize the quality grade of medicinal herbs.
- Quantitative structure-activity relationship methods: perspectives on drug discovery and toxicology.
- Structure-activity relationship approaches and applications.
- Interaction of organophosphate pesticides and related compounds with the androgen receptor.
- Three-dimensional structure-activity relationship modeling of digoxin inhibition and docking to Na+,K+-ATPase.
- Three-dimensional quantitative structure-property relationship (3D-QSPR) models for prediction of thermodynamic properties of polychlorinated biphenyls (PCBs): enthalp...
- Homology model of the CB1 cannabinoid receptor: sites critical for nonclassical cannabinoid agonist interaction.
- Influence of the structural diversity of data sets on the statistical quality of three-dimensional quantitative structure-activity relationship (3D-QSAR) models: predi...
- Three-dimensional quantitative structure-activity relationship analysis of ligand binding to human sequence antidigoxin monoclonal antibodies using comparative molecul...
- Molecular interaction of the antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid recep...
- Computational studies on tetrahydropyrimidine-2-one HIV-1 protease inhibitors: improving three-dimensional quantitative structure-activity relationship comparative mol...
- Three-dimensional quantitative structure-activity relationship study of the inhibition of Na(+),K(+)-ATPase by cardiotonic steroids using comparative molecular field a...
- Three-dimensional quantitative structure--property relationship (3D-QSPR) models for prediction of thermodynamic properties of polychlorinated biphenyls (PCBs): enthal...
- A Novel High-Throughput Approach to Measure Hydroxyl Radicals Induced by Airborne Particulate Matter.
- Novel virtual screening approach for the discovery of human tyrosinase inhibitors.
- Tumor-targeted bioconjugate based delivery of camptothecin: design, synthesis and in vitro evaluation.
- Molecular characterization of thyroid toxicity: anchoring gene expression profiles to biochemical and pathologic end points.
- Persistent interactions between biguanide-based compound NB325 and CXCR4 result in prolonged inhibition of human immunodeficiency virus type 1 infection.
- Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies.
- Oncogene expression profiles in K6/ODC mouse Skin and papillomas following a chronic exposure to monomethylarsonous acid.
- Specific interactions between the viral coreceptor CXCR4 and the biguanide-based compound NB325 mediate inhibition of human immunodeficiency virus type 1 infection.
- Structure-activity relations of nanolipoblockers with the atherogenic domain of human macrophage scavenger receptor A.
- Structure-activity relationships of polybiguanides with activity against human immunodeficiency virus type 1.
- Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in Cancer cell lines.
- Antitumor activity of new substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and study of their effect on the cell cycle.
- Homology modeling of the estrogen receptor subtype beta (ER-beta) and calculation of ligand binding affinities.
- Three-dimensional quantitative structure-activity relationship (3D-QSAR) models for a novel class of piperazine-based stromelysin-1 (MMP-3) inhibitors: applying a "div...
- Determination of vaporization enthalpies of polychlorinated biphenyls by correlation gas chromatography.
- Computational studies on HIV-1 protease inhibitors: influence of calculated inhibitor-enzyme binding affinities on the statistical quality of 3D-QSAR CoMFA models.
- Polynomial neural network for linear and non-linear model selection in quantitative-structure activity relationship studies on the internet.
- Development of a novel class of monocyclic and bicyclic alkyl amides that exhibit CB1 and CB2 cannabinoid receptor affinity and receptor activation.
- Evidence for a strong sulfur-aromatic interaction derived from crystallographic data.
- Comparative molecular field analysis as a tool to evaluate mode of action of chemical hybridization agents.
- Comparison of estrogen receptor alpha and beta subtypes based on comparative molecular field analysis (CoMFA).
- Signal transduction of eicosanoid CB1 receptor ligands.
- Pharmaceutical fingerprinting in phase space. 2. Pattern recognition.
- Pharmaceutical fingerprinting in phase space. 1. Construction of phase fingerprints.
- Regulation of Gi by the CB1 cannabinoid receptor C-terminal juxtamembrane region: structural requirements determined by peptide analysis.
- Three-dimensional quantitative structure-activity relationship study of the cannabimimetic (aminoalkyl)indoles using comparative molecular field analysis.
- Derivation of a pharmacophore model for anandamide using constrained conformational searching and comparative molecular field analysis.
- Evaluation of quantitative structure-activity relationship methods for large-scale prediction of chemicals binding to the estrogen receptor.
- Application of a pruning algorithm to optimize artificial neural networks for pharmaceutical fingerprinting.
- Quantitative structure-activity relationships (QSARs) for estrogen binding to the estrogen receptor: predictions across species.
- QSAR models for binding of estrogenic compounds to estrogen receptor alpha and beta subtypes.
- Preprocessing of HPLC trace impurity patterns by wavelet packets for pharmaceutical fingerprinting using artificial neural networks.
- Pharmaceutical fingerprinting: evaluation of neural networks and chemometric techniques for distinguishing among same-product manufacturers.
- Molecular modeling of substrate-enzyme reactions for the cysteine protease papain.
Schools
Medical College Of Georgia School Of Medicine
Med College Of Georgia
Boston University
Abteilung Weiderherstellung
University Of Georgia
Procedures Preformed
- Abdominoplasty
- Adjacent Tissue Transfer
- Blepharoplasty
- Body Contouring (After Weight Loss Surgery)
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Conditions Treated
- Gynecomastia
- Incisional Hernia
- Skin Aging
- Skin Cancer
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Doctors Specialties
- Plastic Surgery
- Otolaryngology (ENT)
Accepted Insurances
Education
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Boston University Medical Center -
Medical College of Georgia -
Medical College of Georgia School of Medicine
Drug Facts
| NPI NUMBER | 1568401255 | |
| NPPES Provider LastName | WELSH | |
| NPPES Provider FirstName | WILLIAM | |
| NPPES Provider ZIPCode | 906022357 | |
| NPPES Provider State | CA | |
| Specialty Description | Geriatric Medicine | |
| Total Claim Count | 27376.0 | |
| Distinct Opioid Count | 9.0 | |
| Opioid Claim Count | 1122.0 | |
| Percent Opioid Claims | 4.1 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1568401255 |
| Last Name Of The Provider | WELSH |
| First Name Of The Provider | WILLIAM |
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