Professor, Neurosurgery, Virginia Commonwealth University, Medical College of Virginia School of Medicine
Neurosurgery
Dr. William C. Broaddus, MD
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Doctor William C. Broaddus, MD practices Neurosurgery. He went to Case Western Reserve University School of Medicine. He received 2 awards: "Regional Top Doctor" and "Fellow (FAANS)". Doctor William C. Broaddus, MD is a published MD. He published 95 publications, including: 'A biomechanical model of the craniomandibular complex and cervical spine based on the inverted pendulum.' He accepts Medicare payments and is registered with Medicare.gov.
Publications
- Wilms tumor 1 gene, CD97, and the emerging biogenetic profile of glioblastoma.
- Extracorporeal irradiation of tumorous calvaria: a case series.
- Nicotine enhances proliferation, migration, and radioresistance of human malignant glioma cells through EGFR activation.
- Inductively coupled microfluidic pressure meter for in vivo monitoring of Cerebrospinal fluid shunt function.
- Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression.
- A biobehavioral perspective on depressive symptoms in patients with cerebral Astrocytoma.
- PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.
- Effect of WT1 gene silencing on the tumorigenicity of human glioblastoma multiforme cells.
- The alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in Medulloblastoma.
- MDA-7/IL-24 plus radiation enhance survival in animals with intraCranial primary human GBM tumors.
- Wilms tumor 1 expression in malignant Gliomas and correlation of +KTS isoforms with p53 status.
- Neural stem cell-preserving external-beam radiotherapy of central Nervous system malignancies.
- Microarray analysis of MRI-defined tissue samples in glioblastoma reveals differences in regional expression of therapeutic targets.
- Cotreatment with a novel phosphoinositide analogue inhibitor and carmustine enhances chemotherapeutic efficacy by attenuating AKT activity in Gliomas.
- In vitro and in vivo imaging studies of a new endohedral metallofullerene nanoparticle.
- Association of a single nucleotide polymorphism in the matrix metalloproteinase-1 promoter with glioblastoma.
- Heterotypic neuronal differentiation of adult subependymal zone neuronal progenitor cells transplanted to the adult hippocampus.
- Molecular targeting in radiotherapy: epidermal growth factor receptor.
- Glioblastoma multiforme causing calvarial destruction: an unusual manifestation revisited.
- Diagnosis of Erdheim-Chester Disease by using computerized tomography-guided stereotactic biopsy of a caudate lesion. Case report.
- MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells.
- A realistic Brain tissue phantom for intraparenchymal infusion studies.
- Induction of membrane-type-1 matrix metalloproteinase by epidermal growth factor-mediated signaling in Gliomas.
- Progress in Cerebral transplantation of expanded neuronal stem cells.
- Melanoma differentiation-associated 7 (interleukin 24) inhibits growth and enhances radiosensitivity of glioma cells in vitro and in vivo.
- The effects of pentoxifylline on the survival of human glioma cells with continuous and intermittent stereotactic radiosurgery irradiation.
- Graft subsidence after instrument-assisted anterior Cervical fusion.
- Intraparenchymal drug delivery via positive-pressure infusion: experimental and modeling studies of poroelasticity in Brain phantom gels.
- Titanium miniplates or stainless steel wire for Cranial fixation: a prospective randomized comparison.
- Protein Pathway Activation Mapping of Brain Metastasis from Lung and Breast Cancers Reveals Organ Type Specific Drug Target Activation.
- Conjugation of functionalized gadolinium metallofullerenes with IL-13 peptides for targeting and imaging glial Tumors.
- Performance tests of a novel coaxial tube catheter in an in vitro model of intraCranial cell delivery.
- Primary Brain T-cell lymphoma of the lymphoblastic type presenting as altered mental status.
- In vitro angiogenesis by human umbilical vein endothelial cells (HUVEC) induced by three-dimensional co-culture with glioblastoma cells.
- Cytometric catheter for neurosurgical applications.
- Gd-DTPA T1 relaxivity in Brain tissue obtained by convection-enhanced delivery, magnetic resonance imaging and emission spectroscopy.
- MDA-7/IL-24 as a Cancer therapeutic: from bench to bedside.
- Quantification of convection-enhanced delivery to the ischemic Brain.
- The development of MDA-7/IL-24 as a Cancer therapeutic.
- A novel coaxial tube catheter for central nervous system infusions: performance characteristics in Brain phantom gel.
- Ectopic telomerase expression inhibits neuronal differentiation of NT2 neural progenitor cells.
- Minimally invasive procedures. Advances in image-guided delivery of drug and cell therapies into the central Nervous system.
- Cost-efficacy of MR-guided neurointerventions.
- Down-regulation of Wilms'' tumor 1 expression in glioblastoma cells increases radiosensitivity independently of p53.
- Distribution and stability of antisense phosphorothioate oligonucleotides in rodent Brain following direct intraparenchymal controlled-rate infusion.
- Positive pressure infusion of therapeutic agents into Brain tissues: mathematical and experimental simulations.
- Isolation of neuronal progenitor cells from the adult human neocortex.
- Synthesis and characterization of novel ceramide analogs for induction of apoptosis in human Cancer cells.
- Equilibrium and non-equilibrium dynamics of the cranio-mandibular complex and Cervical spine.
- Quantitative assessment of glioblastoma invasion in vivo.
- Neurosurgical delivery of chemotherapeutics, targeted toxins, genetic and viral therapies in neuro-oncology.
- Grafts of adult subependymal zone neuronal progenitor cells rescue hemiparkinsonian behavioral decline.
- Thermodynamics of movable inductively heated seeds for the treatment of Brain tumors.
- Postnatal development of striatal dopamine function. II. Effects of neonatal 6-hydroxydopamine treatments on D1 and D2 receptors, adenylate cyclase activity and presyn...
- Peripheral-type benzodiazepine receptors in human glioblastomas: pharmacologic characterization and photoaffinity labeling of ligand recognition site.
- Preoperative superselective arteriolar embolization: a new approach to enhance resectability of spinal Tumors.
- Magnetic stereotaxis: a technique to deliver stereotactic hyperthermia.
- A neurosurgical approach to far-lateral Disc herniation. Technical note.
- Postnatal development of striatal dopamine function. I. An examination of D1 and D2 receptors, adenylate cyclase regulation and presynaptic dopamine markers.
- Treatment of right hemispheric Cerebral infarction by hemicraniectomy.
- Craniofacial Trauma: an assessment of risk related to timing of surgery.
- Lumboperitoneal shunt combined with myelotomy for treatment of syringohydromyelia.
- Vacuum-stiffened beanbag for Cranial remodeling procedures in modified prone position. Technical note.
- Cranial vault growth in craniosynostosis.
- Detection of shunt-induced intraCerebral hemorrhage by postoperative skull films: a report of two cases.
- Lyophilized cadaver dura mater for primary repair of myelomeningoceles.
- Has monitoring of the contralateral breast improved the prognosis in patients treated for primary breast Cancer?
- Magnesium transport: an independently regulated beta-adrenergic response not mediated by cyclic AMP.
- Adenylate cyclase: the role of magnesium and other divalent cations.
- Symptomatic Lumbar stenosis following fusion using sublaminar hooks. Case report.
- Magnetic neurosurgery.
- Hyperactive pectoralis reflex as an indicator of upper Cervical spinal cord compression. Report of 15 cases.
- Antiproliferative effect of c-myc antisense phosphorothioate oligodeoxynucleotides in malignant glioma cells.
- Intraoperative monitoring of substrate delivery during Aneurysm and hematoma surgery: initial experience in 16 patients.
- Measurement of friction on straight catheters in in vitro Brain and phantom material.
- Accelerated radiotherapy regimen for malignant Gliomas using stereotactic concomitant boosts for dose escalation.
- Distribution of macromolecular dyes in Brain using positive pressure infusion: a model for direct controlled delivery of therapeutic agents.
- A 54-year-old woman with recurrent headaches and seizures.
- A biomechanical model of the craniomandibular complex and Cervical spine based on the inverted pendulum.
- IntraCranial extension of an eccrine porocarcinoma. Case report and review of the literature.
- An in vivo rat model for visualizing glioma tumor cell invasion using stable persistent expression of the green fluorescent protein.
- Strategies for the design and delivery of antisense oligonucleotides in central Nervous system.
- Enhanced radiosensitivity of malignant glioma cells after adenoviral p53 transduction.
- Determination of intracranial tumor volumes in a rodent Brain using magnetic resonance imaging, Evans blue, and histology: a comparative study.
- Central Nervous system leiomyosarcoma in patients with acquired immunodeficiency syndrome. Report of two cases.
- Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing herpes simplex virus-thymidine kinase delivered by slow, rate-controlled positive pr...
- Hypofractionated stereotactic radiotherapy as an alternative to radiosurgery for the treatment of patients with Brain metastases.
- Extracorporeal irradiation of tumorous calvaria. Case report.
- Quantitative three-dimensional analysis and diffusion modeling of oligonucleotide concentrations after direct intraparenchymal Brain infusion.
- Intensity-modulated stereotactic radiosurgery using dynamic micro-multileaf collimation.
- Functional outcomes and quality of life in patients with Brain tumours: a review of the literature.
- Membrane-type matrix metalloproteinases (MT-MMPs): expression and function during glioma invasion.
- The role of matrix metalloproteinase genes in glioma invasion: co-dependent and interactive proteolysis.
- The Influence of Hypoxia and pH on Bioluminescence Imaging of Luciferase-Transfected Tumor Cells and Xenografts.
Schools
Case Western Reserve University
University Va School Med
University Of Ljubljana
Procedures Preformed
- Cerebrospinal Fluid (CSF) Shunt - Insertion, Repair or Removal
- Craniectomy, Craniotomy, Surgery of Skull Base, Neuroendoscopy
- Dural Repair or Other Spinal Spinal Cord Repair
- Epidural Block, Facet Blocks
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Conditions Treated
- Acoustic Neuroma
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
- Brain Aneurysm
- Brain Cancer
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Doctors Specialties
- Neurosurgery
Accepted Insurances
Awards
- Regional Top Doctor
- Fellow (FAANS)
Education
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University of Virginia -
Case Western Reserve University School of Medicine
Drug Facts
| NPI NUMBER | 1033140694 | |
| NPPES Provider LastName | BROADDUS | |
| NPPES Provider FirstName | WILLIAM | |
| NPPES Provider ZIPCode | 232980631 | |
| NPPES Provider State | VA | |
| Specialty Description | Neurosurgery | |
| Total Claim Count | 62.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1033140694 |
| Last Name Of The Provider | BROADDUS |
| First Name Of The Provider | WILLIAM |
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