Professor, Pathology (Basic Science), Stony Brook University SOM
Pathology
Dr. Ute M. Moll, MD
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Moll works in the field of Pathology. Doctor Ute M. Moll, MD is a published physician. She has 99 publications published. The most current publication "Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines."
Publications
- The cortical hypoplasia and ventriculomegaly of p73-deficient mice: a developmental and adult analysis.
- p63 is a prosurvival factor in the adult mammary gland during post-lactational involution, affecting PI-MECs and ErbB2 tumorigenesis.
- Targeting the heat shock protein 90: a rational way to inhibit macrophage migration inhibitory factor function in cancer.
- ÎNp63 regulates select routes of reprogramming via multiple mechanisms.
- p73 - constitutively open for business.
- Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis.
- p53 further extends its reach.
- Direct reprogramming by oncogenic Ras and Myc.
- p73 is dispensable for commitment to neural stem cell fate, but is essential for neural stem cell maintenance and for blocking premature differentiation.
- Generation of p53-deficient induced pluripotent stem cells from mouse embryo fibroblasts.
- Identification of p53 in mitochondria.
- HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer.
- Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression.
- Links between mutant p53 and genomic instability.
- p73 protein regulates DNA damage repair.
- Role of the p53 family in stabilizing the genome and preventing polyploidization.
- Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice.
- p63 and canonical Wnt signaling.
- BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain.
- Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells.
- Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes.
- While p73 is essential, p63 is completely dispensable for the development of the central nervous system.
- Akt-mediated cisplatin resistance in ovarian cancer: modulation of p53 action on caspase-dependent mitochondrial death pathway.
- WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.
- Clinical relevance of dominant-negative p73 isoforms for responsiveness to chemotherapy and survival in ovarian cancer: evidence for a crucial p53-p73 cross-talk in vivo.
- Mitochondrially targeted p53 has tumor suppressor activities in vivo.
- Transcription-independent pro-apoptotic functions of p53.
- Viral and cellular oncogenes induce rapid mitochondrial translocation of p53 in primary epithelial and endothelial cells early in apoptosis.
- A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model.
- Expression levels of p53 and p73 isoforms in stage I and stage III ovarian cancer.
- p73 suppresses polyploidy and aneuploidy in the absence of functional p53.
- The role of ubiquitination in the direct mitochondrial death program of p53.
- Aristolochic acid and the etiology of endemic (Balkan) nephropathy.
- Macrophage migration inhibitory factor coordinates DNA damage response with the proteasomal control of the cell cycle.
- Classic and novel roles of p53: prospects for anticancer therapy.
- p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest.
- The mitochondrial p53 pathway.
- p53 in autophagy control.
- Mitochondrially targeted wild-type p53 induces apoptosis in a solid human tumor xenograft model.
- E2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression.
- p53''s mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity.
- Regulation of autophagy by cytoplasmic p53.
- Impaired DNA damage checkpoint response in MIF-deficient mice.
- Monoubiquitylation promotes mitochondrial p53 translocation.
- Patterns of p73 N-terminal isoform expression and p53 status have prognostic value in gynecological cancers.
- p53 mutations as fingerprints for aristolochic acid: an environmental carcinogen in endemic (Balkan) nephropathy.
- The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells.
- p63 regulation by microRNAs.
- The Role of p63 and p73 in tumor formation and progression: coming of age toward clinical usefulness. Commentary re: F. Koga et al., Impaired p63 expression associates...
- Nuclear and cytoplasmic degradation of endogenous p53 and HDM2 occurs during down-regulation of the p53 response after multiple types of DNA damage.
- deltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo.
- Stress-induced p53 runs a transcription-independent death program.
- Macrophage migration inhibitory factor MIF interferes with the Rb-E2F pathway.
- Stress-induced p53 runs a direct mitochondrial death program: its role in physiologic and pathophysiologic stress responses in vivo.
- Highlights of the National Cancer Institute Workshop on mitochondrial function and cancer.
- Rational design of DNA sequences for nanotechnology, microarrays and molecular computers using Eulerian graphs.
- p63 and p73: roles in development and tumor formation.
- In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation.
- Transdominant DeltaTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo.
- Efficient RNA interference depends on global context of the target sequence: quantitative analysis of silencing efficiency using Eulerian graph representation of siRNA.
- The MDM2-p53 interaction.
- Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage.
- Mutational analysis of p53 in human tumors: immunocytochemistry.
- Mutational analysis of p53 in human tumors: direct DNA sequencing and SSCP.
- Analysis of nuclear and cytoplasmic degradation of p53 in cells after stress.
- Detection of mitochondrial localization of p53.
- p53 has a direct apoptogenic role at the mitochondria.
- DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors.
- DeltaN-p73alpha accumulates in human neuroblastic tumors.
- A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking.
- Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines.
- Loss of p53 function in uterine papillary serous carcinoma.
- p53--an acrobat in tumorigenesis.
- Nuclear overexpression of p53 protein does not correlate with gene mutation in primary peritoneal carcinoma.
- Functional histology of the neuroendocrine thymus.
- Morphologic effects of neoadjuvant chemotherapy in locally advanced breast cancer.
- Clostridium perfringens septicemia with massive hemolysis in a patient with Hodgkin's lymphoma.
- Role of p53 alteration in primary peritoneal carcinoma.
- Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide.
- Uterine papillary serous carcinoma evolves via a p53-driven pathway.
- Double minutes in the papillary thyroid cancer cell line PTC-1113A.
- Plasma assay of gelatinase B: tissue inhibitor of metalloproteinase complexes in cancer.
- Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage.
- p53 mediated tumor cell response to chemotherapeutic DNA damage: a preliminary study in matched pairs of breast cancer biopsies.
- Ovarian carcinoma arising in atypical endometriosis.
- Proteolytic activity of first trimester human placenta: localization of interstitial collagenase in villous and extravillous trophoblast.
- Localization of collagenase at the basal plasma membrane of a human pancreatic carcinoma cell line.
- Tumor promoter-stimulated Mr 92,000 gelatinase secreted by normal and malignant human cells: isolation and characterization of the enzyme from HT1080 tumor cells.
- Extraction of type-IV collagenase/gelatinase from plasma membranes of human cancer cells.
- Primary signet ring cell carcinoma of the uterine cervix.
- Extraction of type IV collagenase/gelatinase from plasma membranes of human pancreatic cancer cells.
- Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.
- The neuroendocrine thymus. Abundant occurrence of oxytocin-, vasopressin-, and neurophysin-like peptides in epithelial cells.
- A biologically active parathyroid hormone-like substance secreted by an adenosquamous carcinoma of the transverse colon.
- Colloidal gold-labeled insulin complex. Characterization and binding to adipocytes.
- Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors.
- Poor prognosis of p53 gene mutation and nuclear overexpression of p53 protein in inflammatory breast carcinoma.
- Inhibition of matrix metalloproteinase 9 activation by a specific monoclonal antibody.
Schools
University Ulm Medical College
University HospSUNY Stony Brook
Doctors Specialties
- Pathology
Accepted Insurances
Education
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SUNY Stony Brook University Hospital & Medical Center -
University of Ulm Faculty of Medicine
Hospital
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Stony Brook University Medical Center
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