Head Molecular Medicine Program, NIH

Internal Medicine

Tracey A. Rouault works in the field of Internal Medicine. Tracey Rouault is a published doctor. He has 102 papers published. The most current publication "Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization."

Publications

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• Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins.
• Targeting ABL1-Mediated Oxidative Stress Adaptation in Fumarate Hydratase-Deficient Cancer.
• Mammalian iron-sulphur proteins: novel insights into biogenesis and function.
• Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery.
• Wild type macrophages reverse disease in heme oxygenase-1 deficient mice.
• Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase.
• Cochaperone Binding to LYR Motifs Confers Specificity of Iron Sulfur Cluster Delivery.
• Iron metabolism in the CNS: implications for neurodegenerative diseases.
• Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle.
• Molecular pathways: fumarate hydratase-deficient kidney cancer--targeting the warburg effect in cancer.
• Insertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron-sulfur cluster enzyme activities and impaired iron homeostasis.
• Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis.
• Mutations in Iron-Sulfur Cluster Scaffold Genes NFU1 and BOLA3 Cause a Fatal Deficiency of Multiple Respiratory Chain and 2-Oxoacid Dehydrogenase Enzymes.
• The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels.
• Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects.
• Hepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts.
• Iron insufficiency compromises motor neurons and their mitochondrial function in irp2-null mice.
• Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution.
• Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway.
• Iron control of erythroid development by a novel aconitase-associated regulatory pathway.
• Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease.
• Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts.
• Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.
• Expression of human frataxin is regulated by transcription factors SRF and TFAP2.
• Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins.
• Cell biology. An ancient gauge for iron.
• Tangled up in red: intertwining of the heme and iron-sulfur cluster biogenesis pathways.
• A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression.
• Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice.
• Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.
• Advancements in the pathophysiology of Friedreich's Ataxia and new prospects for treatments.
• Homeostatic mechanisms for iron storage revealed by genetic manipulations and live imaging of Drosophila ferritin.
• Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells.
• Renal iron metabolism: transferrin iron delivery and the role of iron regulatory proteins.
• Biochemistry. If the RNA fits, use it.
• Brain iron metabolism.
• The role of iron regulatory proteins in mammalian iron homeostasis and disease.
• Of two cytosolic aconitases expressed in Drosophila, only one functions as an iron-regulatory protein.
• Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly.
• Characterization of mitochondrial ferritin in Drosophila.
• Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development.
• Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis.
• The intestinal heme transporter revealed.
• Linking physiological functions of iron.
• Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2.
• Self-association and ligand-induced conformational changes of iron regulatory proteins 1 and 2.
• Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism.
• Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo.
• Identification of a heme-sensing domain in iron regulatory protein 2.
• Microbiology. Pathogenic bacteria prefer heme.
• Sedimentation equilibrium analysis of protein interactions with global implicit mass conservation constraints and systematic noise decomposition.
• Severity of neurodegeneration correlates with compromise of iron metabolism in mice with iron regulatory protein deficiencies.
• How mammals acquire and distribute iron needed for oxygen-based metabolism.
• Compartment-specific protection of iron-sulfur proteins by superoxide dismutase.
• Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene.
• The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2.
• Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster.
• Hepatic iron overload in alcoholic liver disease: why does it occur and what is its role in pathogenesis?
• Iron regulatory protein 2 as iron sensor. Iron-dependent oxidative modification of cysteine.
• A high-capacity RNA affinity column for the purification of human IRP1 and IRP2 overexpressed in Pichia pastoris.
• Post-transcriptional regulation of human iron metabolism by iron regulatory proteins.
• Biochemical and biophysical methods for studying mitochondrial iron metabolism.
• The physiological functions of iron regulatory proteins in iron homeostasis - an update.
• Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma.
• Neuroprotective mechanism of mitochondrial ferritin on 6-hydroxydopamine-induced dopaminergic cell damage: implication for neuroprotection in Parkinson's disease.
• Erythropoiesis and iron sulfur cluster biogenesis.
• Iron-sulfur cluster biogenesis and human disease.
• Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia.
• A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.
• Serum ferritin concentrations in Africans with low dietary iron.
• Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis.
• Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis.
• Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier.
• Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.
• MRI detection of ferritin iron overload and associated neuronal pathology in iron regulatory protein-2 knockout mice.
• Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2.
• Expression of a recombinant IRP-like Plasmodium falciparum protein that specifically binds putative plasmodial IREs.
• Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina.
• Metabolic regulation of citrate and iron by aconitases: role of iron-sulfur cluster biogenesis.
• Neurochemical investigations of dopamine neuronal systems in iron-regulatory protein 2 (IRP-2) knockout mice.
• An iron regulatory-like protein expressed in Plasmodium falciparum displays aconitase activity.
• Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis.
• Numerous proteins in Mammalian cells are prone to iron-dependent oxidation and proteasomal degradation.
• Iron-dependent regulation of the divalent metal ion transporter.
• New ways of initiating translation in eukaryotes.
• An IRP-like protein from Plasmodium falciparum binds to a mammalian iron-responsive element.
• Systemic iron metabolism: a review and implications for brain iron metabolism.
• Association of pulmonary tuberculosis with increased dietary iron.
• Iron on the brain.
• MCV as a guide to phlebotomy therapy for hemochromatosis.
• Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice.
• Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells.
• Iron and alcohol content of traditional beers in rural Zimbabwe.
• Regulation of intracellular iron metabolism in human erythroid precursors by internalized extracellular ferritin.
• Measurements of iron status and survival in African iron overload.
• A traditional beverage prevents iron deficiency in African women of child bearing age.
• Clinical severity and thermodynamic effects of iron-responsive element mutations in hereditary hyperferritinemia-cataract syndrome.
• Iron overload in urban Africans in the 1990s.
• Non-transferrin-bound iron and hepatic dysfunction in African dietary iron overload.
• Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization.
• Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB.

Schools

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• Duke University

Doctors Specialties

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• Rheumatology
• Internal Medicine

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