Assistant Professor, Ophthalmology, Perelman School of Medicine
Ophthalmology
Dr. Tomas S. Aleman, MD
Doctor Tomas S. Aleman, MD is an expert in the field of Ophthalmology. Tomas S. Aleman has written publications. He has 85 publications published with PubMed. The lastest paper is: 'SPATA7: Evolving phenotype from cone-rod dystrophy to retinitis pigmentosa.' He accepts Medicare payments and is listed with Medicare.gov.
Publications
- SPATA7: Evolving phenotype from cone-rod dystrophy to retinitis pigmentosa.
- Obstructive sleep apnea and central serous chorioretinopathy.
- Relationship Between Optic Nerve Appearance and Retinal Nerve Fiber Layer Thickness as Explored with Spectral Domain Optical Coherence Tomography.
- Retinal structure in vitamin A deficiency as explored with multimodal imaging.
- Evidence of Recurrent Microvascular Occlusions Associated with Acute Branch Retinal Artery Occlusion Demonstrated with Spectral-Domain Optical Coherence Tomography.
- Macular Function in Macular Degenerations: Repeatability of Microperimetry as a Potential Outcome Measure for ABCA4-associated Retinopathy Trials.
- Gene Therapy for Retinitis Pigmentosa caused by MFRP (Membrane-type Frizzled Related Protein) Mutations: Human Phenotype and Preliminary Proof-of-Concept.
- Gene Therapy for Leber Congenital Amaurosis Caused by RPE65 Mutations: Safety and Efficacy in 15 Children and Adults Followed Up to 3 Years.
- Retinal Disease Course in Usher Syndrome 1B due to MYO7A Mutations.
- Human CRB1-associated retinal degeneration: comparison with the rd8 Crb1-mutant mouse model.
- Characterisation of a C1qtnf5 Ser163Arg Knock-In Mouse Model of Late-Onset Retinal Macular Degeneration.
- Human retinal disease from AIPL1 gene mutations: foveal cone loss with minimal macular photoreceptors and rod function remaining.
- Variations in NPHP5 in patients with nonsyndromic leber congenital amaurosis and Senior-Loken syndrome.
- Molecular anthropology meets genetic medicine to treat blindness in the North African Jewish population: human gene therapy initiated in Israel.
- Retinal disease in Rpe65-deficient mice: comparison to human leber congenital amaurosis due to RPE65 mutations.
- Visual acuity in patients with Leber's congenital amaurosis and early childhood-onset retinitis pigmentosa.
- Normal central retinal function and structure preserved in retinitis pigmentosa.
- CERKL mutations cause an autosomal recessive cone-rod dystrophy with inner retinopathy.
- Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 year.
- Vision 1 year after gene therapy for Leber's congenital amaurosis.
- Harmonin in the murine retina and the retinal phenotypes of Ush1c-mutant mice and human USH1C.
- Defining the residual vision in leber congenital amaurosis caused by RPE65 mutations.
- Disease boundaries in the retina of patients with Usher syndrome caused by MYO7A gene mutations.
- Leber congenital amaurosis caused by Lebercilin (LCA5) mutation: retained photoreceptors adjacent to retinal disorganization.
- Photoreceptor layer topography in children with leber congenital amaurosis caused by RPE65 mutations.
- Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I tr...
- Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics.
- Retinal disease in Usher syndrome III caused by mutations in the clarin-1 gene.
- Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations.
- Centrosomal-ciliary gene CEP290/NPHP6 mutations result in blindness with unexpected sparing of photoreceptors and visual brain: implications for therapy of Leber conge...
- Inner retinal abnormalities in X-linked retinitis pigmentosa with RPGR mutations.
- Human cone photoreceptor dependence on RPE65 isomerase.
- Canine and human visual cortex intact and responsive despite early retinal blindness from RPE65 mutation.
- Leber congenital amaurosis caused by an RPGRIP1 mutation shows treatment potential.
- Reduced-illuminance autofluorescence imaging in ABCA4-associated retinal degenerations.
- Macular pigment and lutein supplementation in ABCA4-associated retinal degenerations.
- RDH12 and RPE65, visual cycle genes causing leber congenital amaurosis, differ in disease expression.
- Electroretinographic analyses of Rpe65-mutant rd12 mice: developing an in vivo bioassay for human gene therapy trials of Leber congenital amaurosis.
- Retinal disease expression in Bardet-Biedl syndrome-1 (BBS1) is a spectrum from maculopathy to retina-wide degeneration.
- Remodeling of the human retina in choroideremia: rab escort protein 1 (REP-1) mutations.
- Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis.
- Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection.
- Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness.
- Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness.
- ABCA4-associated retinal degenerations spare structure and function of the human parapapillary retina.
- Macular degeneration in a patient with aceruloplasminemia, a disease associated with retinal iron overload.
- Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success.
- In vivo dynamics of retinal injury and repair in the rhodopsin mutant dog model of human retinitis pigmentosa.
- Nonhuman primate models for diabetic ocular neovascularization using AAV2-mediated overexpression of vascular endothelial growth factor.
- Disease expression in Usher syndrome caused by VLGR1 gene mutation (USH2C) and comparison with USH2A phenotype.
- Mutation analysis of NR2E3 and NRL genes in Enhanced S Cone Syndrome.
- Impairment of the transient pupillary light reflex in Rpe65(-/-) mice and humans with leber congenital amaurosis.
- In utero gene therapy rescues vision in a murine model of congenital blindness.
- De novo mutation in the RP1 gene (Arg677ter) associated with retinitis pigmentosa.
- Clinicopathologic effects of mutant GUCY2D in Leber congenital amaurosis.
- Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa.
- The nuclear receptor NR2E3 plays a role in human retinal photoreceptor differentiation and degeneration.
- Genetic heterogeneity in autosomal dominant retinitis pigmentosa with low-frequency damped electroretinographic wavelets.
- Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa.
- Augmented rod bipolar cell function in partial receptor loss: an ERG study in P23H rhodopsin transgenic and aging normal rats.
- Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndrome.
- Gene therapy restores vision in a canine model of childhood blindness.
- Melatonin delays photoreceptor degeneration in the rds/rds mouse.
- Calcium channel blocker D-cis-diltiazem does not slow retinal degeneration in the PDE6B mutant rcd1 canine model of retinitis pigmentosa.
- Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man.
- A homozygous deletion in RPE65 in a small Sardinian family with autosomal recessive retinal dystrophy.
- Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness.
- Stable transgene expression in rod photoreceptors after recombinant adeno-associated virus-mediated gene transfer to monkey retina.
- In vivo micropathology of Best macular dystrophy with optical coherence tomography.
- Spinocerebellar ataxia type 7 (SCA7) shows a cone-rod dystrophy phenotype.
- Macular pigment and lutein supplementation in choroideremia.
- Crumbs homolog 1 (CRB1) mutations result in a thick human retina with abnormal lamination.
- Mutations in ABCA4 result in accumulation of lipofuscin before slowing of the retinoid cycle: a reappraisal of the human disease sequence.
- In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development.
- Evidence for retinal remodelling in retinitis pigmentosa caused by PDE6B mutation.
- Nuclear receptor NR2E3 gene mutations distort human retinal laminar architecture and cause an unusual degeneration.
- Quantifying rod photoreceptor-mediated vision in retinal degenerations: dark-adapted thresholds as outcome measures.
- Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism.
- Full-field stimulus testing (FST) to quantify visual perception in severely blind candidates for treatment trials.
- Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate.
- The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65.
- Cone photoreceptors are the main targets for gene therapy of NPHP5 (IQCB1) or NPHP6 (CEP290) blindness: generation of an all-cone Nphp6 hypomorph mouse that mimics the...
- Subconjunctivally implantable hydrogels with degradable and thermoresponsive properties for sustained release of insulin to the retina.
- ABCA4 disease progression and a proposed strategy for gene therapy.
Doctors Specialties
- Ophthalmology
Accepted Insurances
Education
-
University of Pennsylvania -
Universidad Superior de Ciencias Medicas
Drug Facts
| NPI NUMBER | 1104110303 | |
| NPPES Provider LastName | ALEMAN | |
| NPPES Provider FirstName | TOMAS | |
| NPPES Provider ZIPCode | 19104 | |
| NPPES Provider State | PA | |
| Specialty Description | Ophthalmology | |
| Total Claim Count | 110.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1104110303 |
| Last Name Of The Provider | ALEMAN |
| First Name Of The Provider | TOMAS |
| View All |
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