Physician
Rheumatology
Dr. Timothy W. Behrens, MD
Timothy Behrens works in the field of Rheumatology. He over the years received 1 awards: "Fellow". Timothy W. Behrens has written publications. He has 63 publications published with PubMed. The lastest paper is: 'Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.'
Publications
- The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression.
- Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
- Genetic Modifiers of Age at Onset in Carriers of the G206A Mutation in PSEN1 With Familial Alzheimer Disease Among Caribbean Hispanics.
- Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States.
- A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
- Lupus Nephritis Susceptibility Loci in Women with Systemic Lupus Erythematosus.
- Two Functional Lupus-Associated BLK Promoter Variants Control Cell-Type- and Developmental-Stage-Specific Transcription.
- MHC associations with clinical and autoantibody manifestations in European SLE.
- Genetics of rheumatoid arthritis contributes to biology and drug discovery.
- Inflammation and autoantibody markers identify rheumatoid arthritis patients with enhanced clinical benefit following rituximab treatment.
- Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus.
- A Plasmablast Biomarker for Nonresponse to Antibody Therapy to CD20 in Rheumatoid Arthritis.
- Selective IgA deficiency in autoimmune diseases.
- Common Variants near FRK/COL10A1 and VEGFA are Associated with Advanced Age-related Macular Degeneration.
- Investigation of the HIN200 Locus in UK SLE Families Identifies Novel Copy Number Variants.
- Association of endogenous anti-interferon-α autoantibodies with decreased interferon-pathway and disease activity in patients with systemic lupus erythematosus.
- TRAPing a new gene for autoimmunity.
- Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes.
- The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling.
- Lyp breakdown and autoimmunity.
- Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q.
- Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
- Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.
- A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
- High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
- Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: a validation study.
- European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus.
- Comment on "Reassessment of the role of mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching".
- Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese population.
- Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.
- Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
- Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
- Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilities.
- DNA microarray gene expression profile of marginal zone versus follicular B cells and idiotype positive marginal zone B cells before and after immunization with Strept...
- Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus.
- B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements.
- Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: support for a crucial role of intron 1 polymorphisms.
- Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
- Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus.
- Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9.
- Overexpression of Bcl(XL) in B cells promotes Th1 response and exacerbates collagen-induced arthritis.
- Transmembrane activator and calcium-modulating cyclophilin ligand interactor mutations in common variable immunodeficiency: clinical and immunologic outcomes in hetero...
- STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.
- Role for Msh5 in the regulation of Ig class switch recombination.
- Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.
- An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity.
- Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus.
- Fine-mapping chromosome 20 in 230 systemic lupus erythematosus sib pair and multiplex families: evidence for genetic epistasis with chromosome 16q12.
- In vivo assessment of the relative contributions of deletion, anergy, and editing to B cell self-tolerance.
- Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.
- Basal immunoglobulin signaling actively maintains developmental stage in immature B cells.
- Microarray analyses of peripheral blood cells identifies unique gene expression signature in psoriatic arthritis.
- Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.
- Fatal acute lymphoblastic leukemia in mice transgenic for B cell-restricted bcl-xL and c-myc.
- The use of microarrays to study autoimmunity.
- Late immature B cells (IgMhighIgDneg) undergo a light chain receptor editing response to soluble self-antigen.
- Visualization of the genesis and fate of isotype-switched B cells during a primary immune response.
- Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus.
- PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction.
- Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis.
- Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus.
- Recent advances in the genetics of systemic lupus erythematosus.
Schools
Southern Illinois University At Edwardsville
Doctors Specialties
- Rheumatology
Accepted Insurances
Awards
- Fellow
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