Professor Emeritus of Human Genetics and Internal Medicine
Medical Genetics
Dr. Thomas D. Gelehrter, MD
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Dr. Thomas D. Gelehrter is an expert in the field of Medical Genetics. He researched medicine at Harvard Medical School. Harvard Medical School is a top medical college. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. He has 4 awards "CMS Meaningful Use Stage 1 Certification", "Elected Fellow", "Whos Who in Medicine and Healthcare" and "Elected Member". Doctor Thomas D. Gelehrter, MD is a published doctor. He has 101 papers published. The most current publication "Cyclic nucleotide regulation of PAI-1 mRNA stability. Identification of cytosolic proteins that interact with an a-rich sequence."
Publications
- Clinical Use of the Surgeon General's "My Family Health Portrait" (MFHP) Tool: Opinions of Future Health Care Providers.
- Role of steroid receptor coactivators in glucocorticoid and transforming growth factor beta regulation of plasminogen activator inhibitor gene expression.
- Identification of glucocorticoid receptor domains involved in transrepression of transforming growth factor-beta action.
- Genetic control mechanisms in man and other mammals.
- Unlinked control of multiple glucocorticoid-induced processes in HTC cells.
- Tyrosine transaminase induction in mammalian cells in tissue culture.
- Insulin binding and insulin action in fibroblasts from patients with maturity-onset diabetes of the young.
- Growth state-dependent binding of USF-1 to a proximal promoter E box element in the rat plasminogen activator inhibitor type 1 gene.
- Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the Type-1 plasminogen activator inhibi...
- Glucocorticoid receptor inhibits transforming growth factor-beta signaling by directly targeting the transcriptional activation function of Smad3.
- IL-1beta mediates induction of hepatic type 1 plasminogen activator inhibitor in response to local tissue injury.
- Cyclic nucleotide regulation of PAI-1 mRNA stability. Identification of cytosolic proteins that interact with an a-rich sequence.
- Smad4/DPC4 and Smad3 mediate transforming growth factor-beta (TGF-beta) signaling through direct binding to a novel TGF-beta-responsive element in the human plasminoge...
- Cyclic nucleotide regulation of type-1 plasminogen activator-inhibitor mRNA stability in rat hepatoma cells. Identification of cis-acting sequences.
- Interleukin-1 induction of type-1 plasminogen activator inhibitor (PAI-1) gene expression in the mouse hepatocyte line, AML 12.
- Questioning the need for anonymous genetic counseling and testing.
- Production of tissue-type plasminogen activator (t-PA) and type-1 plasminogen activator inhibitor (PAI-1) in mildly cirrhotic rat liver.
- Mechanism of glucocorticoid induction of the rat plasminogen activator inhibitor-1 gene in HTC rat hepatoma cells: identification of cis-acting regulatory elements.
- Plasminogen activator inhibitor-1 is an immediate early response gene in regenerating rat liver.
- Synergistic induction of tissue-type plasminogen activator gene expression by glucocorticoids and cyclic nucleotides in rat HTC hepatoma cells.
- Induction of plasminogen activator inhibitor-1 in HepG2 human hepatoma cells by mediators of the acute phase response.
- Type 1 plasminogen activator inhibitor is not an acute phase reactant in rats. Lack of IL-6- and hepatocyte-dependent synthesis.
- Glucocorticoid inhibition of two discrete glycine transport systems in rat hepatoma cells.
- Glucocorticoid regulation of amino acid transport in anucleate rat hepatoma (HTC) cells.
- Loss of glucocorticoid regulation of plasminogen activator activity in anucleate rat hepatoma cells.
- Desensitization of hepatoma cells to insulin action. Evidence for a post-receptor mechanism.
- The dexamethasone-induced inhibitor of fibrinolytic activity in hepatoma cells. A cellular product which specifically inhibits plasminogen activation.
- Dexamethasone induction of an inhibitor of plasminogen activator in HTC hepatoma cells.
- The family history and genetic counseling. Tools for preventing and managing inherited disorders.
- Insulin regulation of Na/K pump activity in rat hepatoma cells.
- Role of plasminogen activator in the morphological alterations induced by derivatives of adenosine cyclic 3':5'-monophosphate in hepatoma tissue culture cells.
- Hormonal regulation of plasminogen activator in rat hepatoma cells.
- Melittin stimulates Na entry, Na-K pump activity and DNA synthesis in quiescent cultures of mouse cells.
- Hormonal regulation of membrane phenotype in hepatoma cells.
- Stimulation of monovalent ion fluxes and DNA synthesis in 3T3 cells by melittin and vasopressin is not mediated by phospholipid deacylation.
- Dexamethasone regulates the program of secretory glycoprotein synthesis in hepatoma tissue culture cells.
- Paradoxical effects of glucocorticoids on regulation of plasminogen activator activity of rat hepatoma cells.
- Paradoxical effects of glucocorticoids on regulation of plasminogen activator activity. Mediation by glucocorticoid receptors.
- Insulin regulation of insulin-like growth factor action in rat hepatoma cells.
- Insulin resistance in H-35 rat hepatoma cells is mediated by post-receptor mechanisms.
- Steroid specificity of the glucocorticoid inhibition of amino acid transport in rat hepatoma cells.
- Induction of tyrosine aminotransferase and amino acid transport in rat hepatoma cells by insulin and the insulin-like growth factor, multiplication-stimulating activit...
- Regulation of insulin responsiveness in rat hepatoma cells.
- The role of RNA in the hormonal induction of tyrosine aminotransferase in mammalian cells in tissue culture.
- Lysergic acid diethylamide (LSD) and exstrophy of the bladder.
- Lethal neonatal deficiency of carbamyl phosphate synthetase.
- Induction of tyrosine aminotransferase by dexamethasone, insulin, and serum. Characterization of the induced enzyme.
- Mechanisms of hormonal induction of enzymes.
- Posttranscriptional control of tyrosine aminotransferase synthesis by insulin.
- Induction of tyrosine aminotransferase by Sepharose-insulin.
- Selectivity of interferon action: hormonal induction of tyrosine aminotransferase in rat hepatoma cells is much less sensitive to interferon than the replication of ve...
- Hormonal regulation of protein degradation in hepatoma cells in tissue culture.
- Pseudoisozymes of hepatic tyrosine aminotransferase.
- Expression of tyrosine aminotransferase activity in somatic-cell heterokaryons: evidence for negative control of enzyme expression.
- The dexamethasone-induced inhibitor of plasminogen activator in hepatoma cells is antigenically-related to an inhibitor produced by bovine aortic endothelial cells.
- Cloning and sequencing of cDNA for the rat plasminogen activator inhibitor-1.
- Dexamethasone inhibition of tissue-type plasminogen activator (tPA) activity: paradoxical induction of both tPA antigen and plasminogen activator inhibitor.
- Immunoaffinity purification of HTC rat hepatoma cell plasminogen activator-inhibitor-1.
- cDNA cloning of human plasminogen activator-inhibitor from endothelial cells.
- Madin-Darby canine kidney cells display type I and type II insulin-like growth factor (IGF) receptors.
- Characterization of the dexamethasone-induced inhibitor of plasminogen activator in HTC hepatoma cells.
- Mediation of insulin-like growth factor actions by the insulin receptor in H-35 rat hepatoma cells.
- Regulation of insulin and insulin-like growth factor (IGF) responsiveness by IGFs in rat hepatoma cells.
- Determination of exon-intron structure: a novel application of the polymerase chain reaction technique.
- Glucocorticoid and cyclic nucleotide regulation of plasminogen activator and plasminogen activator-inhibitor gene expression in primary cultures of rat hepatocytes.
- Glucocorticoid induction of plasminogen activator and plasminogen activator-inhibitor messenger RNA in rat hepatoma cells.
- Thrombin induction of plasminogen activator-inhibitor in cultured human endothelial cells.
- p52 induction by cytochalasin D in rat kidney fibroblasts: homologies between p52 and plasminogen activator inhibitor type-1.
- Isolation and characterization of the rat plasminogen activator inhibitor-1 gene.
- Cyclic nucleotide regulation of plasminogen activator and plasminogen activator-inhibitor messenger RNAs in rat hepatoma cells.
- Endotoxin induction of plasminogen activator and plasminogen activator inhibitor type 1 mRNA in rat tissues in vivo.
- Differential expression of urokinase-type plasminogen activator and its type-1 inhibitor during healing of mouse skin wounds.
- Transforming growth factor beta inhibits plasminogen activator (PA) activity and stimulates production of urokinase-type PA, PA inhibitor-1 mRNA, and protein in rat os...
- Transcriptional and posttranscriptional regulation of type 1 plasminogen activator inhibitor and tissue-type plasminogen activator gene expression in HTC rat hepatoma ...
- Glucocorticoid regulation of plasminogen activator inhibitor-1 messenger ribonucleic acid and protein in normal and malignant rat osteoblasts.
- Regulatory sequences and protein-binding sites involved in the expression of the rat plasminogen activator inhibitor-1 gene.
- Thrombin induction of plasminogen activator inhibitor mRNA in human umbilical vein endothelial cells in culture.
- Plasminogen activator regulation in osteoblasts: parathyroid hormone inhibition of type-1 plasminogen activator inhibitor and its mRNA.
- Variable expression of Marfan syndrome in monozygotic twins.
- Ornithine transcarbamylase deficiency. Unsuccessful therapy of neonatal hyperammonemia with N-carbamyl-L-glutamate and L-arginine.
- X-chromosome inactivation in human liver: confirmation of X-linkage of ornithine transcarbamylase.
- Familial Turner syndrome.
- Gllcocorticoid inhibition of amino acid transport in rat hepatoma cells.
- Hemolytic anemia in Wilson''s disease. A report of three cases with transient increase in hemoglobin A2.
- Dexamethasone-induced adhesion in hepatoma cells: the role of plasminogen activator.
- Isolation of rat hepatoma cell variants selectively resistant to dexamethasone inhibition of plasminogen activator.
- Glucocorticoids and the plasma membrane.
- Insulin induction of tyrosine aminotransferase in synchronized hepatoma cells.
- Hormonal regulation of membrane phenotype.
- Adrenal steroids, membranes and neoplasia.
- Mechanism of dexamethasone inhibition of plasminogen activator in rat hepatoma cells.
- Enzyme induction (second of three parts).
- Syneristic and antagonistic effects of glucocorticoids on insulin action.
- Control of specific gene expression in higher organisms. Expression of mammalian genes may be controlled by repressors acting on the translation of messenger RNA.
- Insulin selectively slows the degradation rate of tyrosine aminotransferase.
- Derepression of amino acid transport by amino acid starvation in rat hepatoma cells.
- Enzyme induction (first of three parts).
- Enzyme induction (third of three parts).
- Control of tyrosine aminotransferase synthesis in tissue culture by a factor in serum.
- Hormonal modulation of amino acid transport in rat hepatoma cells in tissue culture.
Schools
Harvard Medical School
Massachusetts General Hospital
NiamdNih
University of Washington
Doctors Specialties
- Clinical Genetics
- Internal Medicine
- Medical Genetics
Accepted Insurances
- Choice Plus POS II
- Blue Card PPO
- Blue Cross Blue Shield of Illinois PPO
- Blue Care Network PCP Focus Network
- Group Employees PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Cofinity PPO
- Commercial Insurance Company
- First Health (Coventry Health Care) PPO
- Health Alliance
- Preferred PPO
- Choice Care PPO
- Medicaid
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Paramount
- Priority PPO
- Choice Plus POS
- Options PPO
Awards
- CMS Meaningful Use Stage 1 Certification
- Elected Fellow
- Whos Who in Medicine and Healthcare
- Elected Member
Education
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Massachusetts General Hospital -
Harvard Medical School
Hospital
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University of Michigan Hospitals and Health Centers
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