Professor, Pediatrics, University Massachusetts Medical School
Pediatric Pulmonology
Dr. Terence R. Flotte, MD
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Terence R. Flotte, MD works in the field of Pediatric Pulmonology. He went to medical school at Louisiana State University School of Medicine in New Orleans. Terence Flotte is a published physician as well. He has 95 publications published. The latest was: STABILITY AND COMPATIBILITY OF RECOMBINANT ADENO-ASSOCIATED VIRUS (rAAV) UNDER CONDITIONS COMMONLY ENCOUNTERED IN HUMAN GENE THERAPY TRIALS.
Publications
- STABILITY AND COMPATIBILITY OF RECOMBINANT ADENO-ASSOCIATED VIRUS (rAAV) UNDER CONDITIONS COMMONLY ENCOUNTERED IN HUMAN GENE THERAPY TRIALS.
- Current status of gene therapy for α-1 antitrypsin deficiency.
- Charting a Clear Path: The ASGCT Standardized Pathways Conference.
- What is suppression of anti-adeno-associated virus capsid T-cells achieving?
- Birth of a New Therapeutic Platform: 47 Years of Adeno-associated Virus Biology From Virus Discovery to Licensed Gene Therapy.
- A Single Intravenous rAAV Injection as Late as P20 Achieves Efficacious and Sustained CNS Gene Therapy in Canavan Mice.
- Effect of allergy and inflammation on eicosanoid gene expression in CFTR deficiency.
- rAAV Integration Sites in Murine Liver After OTC Gene Correction.
- Gene-based therapy for alpha-1 antitrypsin deficiency.
- Gene transfer in skeletal and cardiac muscle using recombinant adeno-associated virus.
- Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases.
- Gene transfer in the lung using recombinant adeno-associated virus.
- Cell and gene therapy for genetic diseases: inherited disorders affecting the lung and those mimicking sudden infant death syndrome.
- Long-term Correction of Very Long-chain Acyl-CoA Dehydrogenase Deficiency in Mice Using AAV9 Gene Therapy.
- Sustained miRNA-mediated Knockdown of Mutant AAT With Simultaneous Augmentation of Wild-type AAT Has Minimal Effect on Global Liver miRNA Profiles.
- Effect of cigarette smoke exposure and structural modifications on the alpha-1 antitrypsin interaction with caspases.
- Induction of group IVC phospholipase A2 in allergic asthma: transcriptional regulation by TNFα in bronchoepithelial cells.
- The Role of Gene and Cell Therapy in the Era of Health Care Reform.
- Phase 2 Clinical Trial of a Recombinant Adeno-associated Virus Vector Expressing Alpha 1 Antitrypsin: Interim Results.
- Moving Forward Toward a Cure for Parkinson's: Neuropathology of the Nigrostriatal Pathway Determines the Location of Growth Factor Delivery.
- Cellular fusion for gene delivery to SCA1 affected Purkinje neurons.
- Recombinant Adeno-Associated Virus-Mediated Gene Transfer for the Potential Therapy of Adenosine Deaminase-Deficient Severe Combined Immune Deficiency.
- MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression.
- Preclinical evaluation of a recombinant adeno-associated virus vector expressing human alpha-1 antitrypsin made using a recombinant herpes simplex virus production met...
- Preclinical Study Design for rAAV.
- No immune responses by the expression of the yeast ndi1 protein in rats.
- Autoimmunity in a genetic disease—a cautionary tale.
- Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material.
- Lack of Cftr in CD3+ Lymphocytes Leads to Aberrant Cytokine Secretion and Hyper-inflammatory Adaptive Immune Responses.
- N-glycosylation Augmentation of the Cystic Fibrosis Epithelium Improves Pseudomonas aeruginosa Clearance.
- Dual reporter comparative indexing of rAAV pseudotyped vectors in chimpanzee airway.
- Modulation of exaggerated-IgE allergic responses by gene transfer-mediated antagonism of IL-13 and IL-17e.
- Endocrine parameters of cystic fibrosis: back to basics.
- Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy.
- Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis.
- Murine model for cystic fibrosis bone disease demonstrates osteopenia and sex-related differences in bone formation.
- Recombinant AAV serotype and capsid mutant comparison for pulmonary gene transfer of alpha-1-antitrypsin using invasive and noninvasive delivery.
- Gene therapy for cystic fibrosis.
- Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I tr...
- CFTR mutations impart elevated immune reactivity in a murine model of cystic fibrosis related diabetes.
- Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics.
- Apparently nonspecific enzyme elevations after portal vein delivery of recombinant adeno-associated virus serotype 2 vector in hepatitis C virus-infected chimpanzees.
- Biochemical correction of short-chain acyl-coenzyme A dehydrogenase deficiency after portal vein injection of rAAV8-SCAD.
- In utero efficacy of cystic fibrosis gene therapy: difficult studies, positive or negative.
- Neonatal intraperitoneal or intravenous injections of recombinant adeno-associated virus type 8 transduce dorsal root ganglia and lower motor neurons.
- Recombinant adeno-associated virus-mediated global anterograde delivery of glial cell line-derived neurotrophic factor to the spinal cord: comparison of rubrospinal an...
- Gene therapy: the first two decades and the current state-of-the-art.
- In vivo post-transcriptional gene silencing of alpha-1 antitrypsin by adeno-associated virus vectors expressing siRNA.
- Preclinical characterization of a recombinant adeno-associated virus type 1-pseudotyped vector demonstrates dose-dependent injection site inflammation and disseminatio...
- Viral vector-mediated and cell-based therapies for treatment of cystic fibrosis.
- Phase I trial of intramuscular injection of a recombinant adeno-associated virus serotype 2 alphal-antitrypsin (AAT) vector in AAT-deficient adults.
- IL-10 regulation of lupus in the NZM2410 murine model.
- alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis.
- Recent developments in the protection of pediatric research subjects.
- Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis.
- Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury.
- Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection.
- In vivo complementation of complex I by the yeast Ndi1 enzyme. Possible application for treatment of Parkinson disease.
- Enhanced IgE allergic response to Aspergillus fumigatus in CFTR-/- mice.
- Systemic correction of a fatty acid oxidation defect by intramuscular injection of a recombinant adeno-associated virus vector.
- Recurrent pneumonia in children: a case report and approach to diagnosis.
- Adeno-associated virus-based gene therapy for inherited disorders.
- The short apical membrane half-life of rescued {Delta}F508-cystic fibrosis transmembrane conductance regulator (CFTR) results from accelerated endocytosis of {Delta}F5...
- Efficient hepatic delivery and expression from a recombinant adeno-associated virus 8 pseudotyped alpha1-antitrypsin vector.
- Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts.
- Correlation between DNA transfer and cystic fibrosis airway epithelial cell correction after recombinant adeno-associated virus serotype 2 gene therapy.
- Adeno-associated virus-mediated gene transfer for lung diseases.
- Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway.
- Adeno-associated virus: a ubiquitous commensal of mammals.
- Herpesvirus-based infectious titering of recombinant adeno-associated viral vectors.
- Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors.
- Ex vivo transduced liver progenitor cells as a platform for gene therapy in mice.
- Effects of CFTR, interleukin-10, and Pseudomonas aeruginosa on gene expression profiles in a CF bronchial epithelial cell Line.
- Functional characterization of a recombinant adeno-associated virus 5-pseudotyped cystic fibrosis transmembrane conductance regulator vector.
- Functional expression of the single subunit NADH dehydrogenase in mitochondria in vivo: a potential therapy for complex I deficiencies.
- Immune responses to recombinant adeno-associated virus vectors: putting preclinical findings into perspective.
- DNA-dependent PK inhibits adeno-associated virus DNA integration.
- Phase I trial of intramuscular injection of a recombinant adeno-associated virus alpha 1-antitrypsin (rAAV2-CB-hAAT) gene vector to AAT-deficient adults.
- Successful transgene expression with serial doses of aerosolized rAAV2 vectors in rhesus macaques.
- Glucose-responsive expression of the human insulin promoter in HepG2 human hepatoma cells.
- Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.
- Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus serotype 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients: ...
- The signal and the trap: targeted delivery and retention of proteins in the mitochondrion.
- Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors.
- The murine alpha(1)-proteinase inhibitor gene family: polymorphism, chromosomal location, and structure.
- Deposition and expression of aerosolized rAAV vectors in the lungs of Rhesus macaques.
- Gene therapy for pyruvate dehydrogenase E1alpha deficiency using recombinant adeno-associated virus 2 (rAAV2) vectors.
- Intramuscular administration of recombinant adeno-associated virus 2 alpha-1 antitrypsin (rAAV-SERPINA1) vectors in a nonhuman primate model: safety and immunologic as...
- A single-subunit NADH-quinone oxidoreductase renders resistance to mammalian nerve cells against complex I inhibition.
- A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies.
- Improved method of recombinant AAV2 delivery for systemic targeted gene therapy.
- Recombinant adeno-associated virus gene therapy for cystic fibrosis and alpha(1)-antitrypsin deficiency.
- Transduction of human and mouse pancreatic islet cells using a bicistronic recombinant adeno-associated viral vector.
- Adeno-associated viral vectors for CF gene therapy.
Schools
Louisiana State University School of Medicine In New Orleans
Johns Hopkins Hospital
Doctors Specialties
- Pediatric Pulmonology
Accepted Insurances
Education
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Johns Hopkins University -
Louisiana State University School of Medicine in New Orleans
Hospital
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UMass Memorial Medical Center
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