Professor of Pediatrics, Boston Children's Hospital
Pediatrics
Dr. Talal Chatila, MD
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Talal Chatila works in the field of Pediatrics. He received 1 awards: "Super Doctor". Talal Chatila is a published doctor as well. He has 100 publications published. The latest was: Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene.
Publications
- Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling.
- The 2015 IUIS Phenotypic Classification for Primary Immunodeficiencies.
- Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficienc...
- The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency.
- Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade.
- MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces Commensalism.
- Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.
- Renal involvement in the immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) disorder.
- DOCK8 deficiency: clinical and immunological phenotype and treatment options - a review of 136 patients.
- Regulatory T Cell Reprogramming toward a Th2-Cell-like Lineage Impairs Oral Tolerance and Promotes Food Allergy.
- Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome Associated with Neonatal Epidermolysis Bullosa Acquisita.
- Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like disorder caused by loss-of-function mutations in LRBA.
- Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells.
- Oral immunotherapy induces IgG antibodies that act through FcgammaRIIb to suppress IgE-mediated hypersensitivity.
- Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency.
- Regulatory T cells: exosomes deliver tolerance.
- Immunoglobulin E Signal Inhibition during Allergen Ingestion Leads to Reversal of Established Food Allergy and Induction of Regulatory T Cells.
- Successful interferon-alpha 2b therapy for unremitting warts in a patient with DOCK8 deficiency.
- Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-alpha 2b therapy.
- Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency.
- Primary Immune Deficiency Treatment Consortium (PIDTC) report.
- Flow cytometry biomarkers distinguish DOCK8 deficiency from severe atopic dermatitis.
- Editorial: Optimizing iTreg differentiation: STATs in the balance.
- Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy.
- A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis.
- Fox family ties.
- Identification of a novel mutation in ZAP70 and prenatal diagnosis in a Turkish family with severe combined immunodeficiency disorder.
- IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy.
- Glucagon regulates ACC activity in adipocytes through the CAMKKβ/AMPK pathway.
- GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells.
- In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif.
- Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses.
- T-cell effector pathways in allergic diseases: transcriptional mechanisms and therapeutic targets.
- NF-kappaB and the innate immune response in the respiratory distress syndrome of the newborn: commentary on the article by Cheah et al. on page 616.
- Regulatory T cell development in the absence of functional Foxp3.
- Regulatory T cells dynamically control the primary immune response to foreign antigen.
- FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease.
- Selective engagement of plasticity mechanisms for motor memory storage.
- Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient mice.
- Regulation of osteoclast differentiation and function by the CaMK-CREB pathway.
- Critical function of the CD40 pathway in parvovirus B19 infection revealed by a hypomorphic CD40 ligand mutation.
- Role of regulatory T cells in human diseases.
- Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice.
- Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation.
- Interleukin-4 receptor signaling pathways in asthma pathogenesis.
- Increased prevalence of mutations in the cystic fibrosis transmembrane conductance regulator in children with chronic rhinosinusitis.
- Defective apoptosis in lymphocytes and the role of IL-2 in autoimmune hematologic cytopenias.
- Response of refractory Kawasaki disease to pulse steroid and cyclosporin A therapy.
- Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease.
- Response to steroid therapy in autism secondary to autoimmune lymphoproliferative syndrome.
- The Epstein-Barr virus-induced Ca2+/calmodulin-dependent kinase type IV/Gr promotes a Ca(2+)-dependent switch from latency to viral replication.
- Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene.
- Light microscopic, immunophenotypic, and molecular genetic study of autoimmune lymphoproliferative syndrome caused by fas mutation.
- Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II).
- Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr.
- A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR.
- Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member.
- HIV glycoprotein gp120 inhibits TCR-CD3-mediated activation of fyn and lck.
- Microbial superantigens induce NF-kappa B in the human monocytic cell line THP-1.
- Severe combined immunodeficiency with selective T-cell cytokine genes.
- Staphylococcal superantigens as inducers of signal transduction in MHC class II-positive cells.
- Early activation events induced by the staphylococcal superantigen toxic shock syndrome toxin-1 in human peripheral blood monocytes.
- Activator protein-1 (AP-1) is stimulated by microbial superantigens in human monocytic cells.
- Signal transduction by microbial superantigens via MHC class II molecules.
- Superantigens activate HIV-1 gene expression in monocytic cells.
- Engagement of MHC class I molecules induces cell adhesion via both LFA-1-dependent and LFA-1-independent pathways.
- Defective expression of early activation genes in cartilage-hair hypoplasia (CHH) with severe combined immunodeficiency (SCID).
- Transcriptional activation of the human TNF-alpha promoter by superantigen in human monocytic cells: role of NF-kappa B.
- Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM.
- The T cell receptor associated CD3-epsilon protein is phosphorylated upon T cell activation in the two tyrosine residues of a conserved signal transduction motif.
- A syndrome involving immunodeficiency and multiple intestinal atresias.
- Calcium activates serum response factor-dependent transcription by a Ras- and Elk-1-independent mechanism that involves a Ca2+/calmodulin-dependent kinase.
- Engagement of the common leukocyte antigen CD45 induces homotypic adhesion of activated human T cells.
- The staphylococcal toxic shock syndrome toxin 1 triggers B cell proliferation and differentiation via major histocompatibility complex-unrestricted cognate T/B cell in...
- Proliferation of highly purified T cells in response to signaling via surface receptors requires cell-cell contact.
- An immunodeficiency characterized by defective signal transduction in T lymphocytes.
- Recombinant interleukin 2 therapy in severe combined immunodeficiency disease.
- Toxic shock syndrome toxin-1 induces inositol phospholipid turnover, protein kinase C translocation, and calcium mobilization in human T cells.
- Requirements for activation of human peripheral blood T cells by mouse monoclonal antibodies to CD3.
- Association of neuronal pp60c-src with growth cone glycoproteins of rat brain.
- Signals delivered via MHC class II molecules synergize with signals delivered via TCR/CD3 to cause proliferation and cytokine gene expression in T cells.
- Cellular and molecular mechanisms of immune activation by microbial superantigens: studies using toxic shock syndrome toxin-1.
- Role of protein kinase activation in the induction of B cell adhesion by MHC class II ligands.
- Superantigens.
- Toxic shock syndrome toxin-1, toxic shock, and the immune system.
- Engagement of MHC-class II molecules by staphylococcal exotoxins delivers a comitogenic signal to human B cells.
- Expression of a neuronal Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, in rat thymus.
- Novel immune deficiencies: defective transcription of lymphokine genes.
- Transcriptional activation of IL-1 beta and tumor necrosis factor-alpha genes by MHC class II ligands.
- Signal transduction via leukocyte antigen CD43 (sialophorin). Feedback regulation by protein kinase C.
- Engagement of major histocompatibility complex class II molecules induces sustained, lymphocyte function-associated molecule 1-dependent cell adhesion.
- Primary combined immunodeficiency resulting from defective transcription of multiple T-cell lymphokine genes.
- T-cell antigen receptor (TCR)-alpha/beta heterodimer formation is a prerequisite for association of CD3-zeta 2 into functionally competent TCR.CD3 complexes.
- Mechanism of mononuclear cell activation by an anti-CD43 (sialophorin) agonistic antibody.
- Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules.
- Mechanisms of T cell activation by the calcium ionophore ionomycin.
- Role of protein tyrosine phosphorylation in monokine induction by the staphylococcal superantigen toxic shock syndrome toxin-1.
- Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules.
- Requirement for mitogen, T cell-accessory cell contact, and interleukin 1 in the induction of resting T-cell proliferation.
Schools
American University Of Beirut Faculty Of Medicine
Conditions Treated
- Hypogammaglobulinemia
Doctors Specialties
- Pediatrics
Accepted Insurances
Awards
- Super Doctor
Education
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American University of Beirut Faculty of Medicine
Hospital
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Boston Children's Hospital
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