Associate Professor, Pediatrics, University of California, Irvine College of Medicine

Pediatric Endocrinology

Susan J. Clark practices Pediatric Endocrinology. She studied medicine at Loma Linda University School of Medicine. Susan Clark is a published doctor and has 46 publications published. The lastest was: 'Integrative genome-wide expression and promoter DNA methylation profiling identifies a potential novel panel of ovarian cancer epigenetic biomarkers.'

Publications

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• Integrative genome-wide expression and promoter DNA methylation profiling identifies a potential novel panel of ovarian cancer epigenetic biomarkers.
• Prognostic and diagnostic significance of DNA methylation patterns in high grade serous ovarian cancer.
• miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA.
• Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells.
• Lineage Specific Methylation of the Elf5 Promoter in Mammary Epithelial Cells.
• Acetylation of H2A.Z is a key epigenetic modification associated With gene deregulation and epigenetic remodeling in cancer.
• Epigenetics in Prostate Cancer: Biologic and Clinical Relevance.
• Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer.
• MicroRNA Alterations and Associated Aberrant DNA Methylation Patterns across Multiple Sample Types in Oral Squamous Cell Carcinoma.
• Impact of the genome on the epigenome is manifested in DNA methylation patterns of imprinted regions in monozygotic and dizygotic twins.
• Epigenetic deregulation across chromosome 2q14.2 differentiates normal from prostate cancer and provides a regional panel of novel DNA methylation cancer biomarkers.
• Comparison of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal CpG sequence c...
• Evaluation of affinity-based genome-wide DNA methylation data: effects of CpG density, amplification bias, and copy number variation.
• Protocol matters: which methylome are you actually studying?
• DNA methylation changes in ovarian cancer: implications for early diagnosis, prognosis and treatment.
• Epigenetic markers of ovarian cancer.
• Concordant epigenetic silencing of transforming Growth factor-beta signaling pathway genes occurs early in breast carcinogenesis.
• Telomere-driven karyotypic complexity concurs With p16INK4a inactivation in TP53-competent immortal endothelial cells.
• Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band.
• Bisulphite differential denaturation PCR for analysis of DNA methylation.
• Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation.
• Incidence of low free T4 values in premature infants as determined by direct equilibrium dialysis.
• Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells.
• Bisulfite methylation analysis of tumor suppressor genes in prostate cancer from fresh and archival tissue samples.
• DNA methylation changes in leukaemia.
• Conversion-specific detection of DNA methylation using real-time polymerase chain reaction (ConLight-MSP) to avoid false positives.
• Methylation sequencing from limiting DNA: embryonic, fixed, and microdissected cells.
• Identification and resolution of artifacts in bisulfite sequencing.
• DNA methylation analysis in mammalian cells.
• Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association With chromatin remodelling and mimics nucleosome positioning.
• DNA methylation: bisulphite modification and analysis.
• Breast cancer epigenetics: normal human mammary epithelial cells as a model system.
• Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts.
• Headloop suppression PCR and its application to selective amplification of methylated DNA sequences.
• Epigenetic architecture and miRNA: reciprocal regulators.
• Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells.
• Action at a distance: epigenetic silencing of large chromosomal regions in carcinogenesis.
• DNA methylation and gene silencing in cancer: which is the guilty party?
• Genomic profiling of CpG methylation and allelic specificity using quantitative high-throughput mass spectrometry: critical evaluation and improvements.
• Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated With aneuploidy.
• Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity.
• Discovery pipeline for epigenetically deregulated miRNAs in cancer: integration of primary miRNA transcription.
• Repitools: an R package for the analysis of enrichment-based epigenomic data.
• Epigenetic and phenotypic changes result from a continuous pre and post natal dietary exposure to phytoestrogens in an experimental population of mice.
• Low O6-methylguanine-DNA methyltransferase (MGMT) expression and response to temozolomide in aggressive pituitary tumours.

Schools

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• Loma Linda University

• Loma Linda University Med Center

Procedures Preformed

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• Continuous Glucose Monitoring

Conditions Treated

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• Abnormal Thyroid
• Acromegaly and Gigantism
• Adrenal Insufficiency
• Adrenogenital Disorders
• View All

Doctors Specialties

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• Pediatric Endocrinology

Accepted Insurances

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Education

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• Loma Linda University
• Loma Linda University School of Medicine

Hospital

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• Children's Hospital of Orange County

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