Associate Professor, Medicine, Perelman School of Medicine
Infectious Disease
Dr. Stuart N. Isaacs, MD
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Dr. Stuart N. Isaacs practices Infectious Disease. He researched medicine at Yale University School of Medicine. Yale University School of Medicine is a top medical college. Yale University School of Medicine is ranked 7/57 in Research/PrimaryCare. Stuart Isaacs has written publications. He has 55 publications published with PubMed. The lastest publication is: 'Functional analysis of vaccinia virus B5R protein: role of the cytoplasmic tail.'
Publications
- A Novel Target and Approach for Identifying Antivirals against Molluscum Contagiosum Virus.
- Adsorption of recombinant poxvirus L1-protein to aluminum hydroxide/CpG vaccine adjuvants enhances immune responses and protection of mice from vaccinia virus challenge.
- Enzyme-linked immunosorbent assay (ELISA) and blocking with bovine serum albumin (BSA)-not all BSAs are alike.
- Working safely with vaccinia virus: laboratory technique and review of published cases of accidental laboratory infections.
- Treating Tumors With a Vaccinia Virus Expressing IFN? Illustrates the Complex Relationships Between Oncolytic Ability and Immunogenicity.
- The vaccinia virus A56 protein: A multifunctional transmembrane glycoprotein that anchors two secreted viral proteins.
- The Vaccinia virus complement control protein modulates adaptive immune responses during infection.
- A stimulating way to improve T cell responses to poxvirus-vectored vaccines.
- Antibody against Extracellular Vaccinia Virus (EV) Protects Mice through Complement and Fc Receptors.
- Poxvirus complement control proteins are expressed on the cell surface through an intermolecular disulfide bridge with the viral A56 protein.
- Therapeutic Vaccines and Antibodies for Treatment of Orthopoxvirus Infections.
- Listeria monocytogenes delivery of HPV-16 major capsid protein L1 induces systemic and mucosal cell-mediated CD4+ and CD8+ T-cell responses after oral immunization.
- A role for the host coatomer and KDEL receptor in early vaccinia biogenesis.
- Cell surface expression of the vaccinia virus complement control protein is mediated by interaction with the viral A56 protein and protects infected cells from complem...
- Major neutralizing sites on vaccinia virus glycoprotein B5 are exposed differently on variola virus ortholog B6.
- B5-deficient vaccinia virus as a vaccine vector for the expression of a foreign antigen in vaccinia immune animals.
- Smallpox subunit vaccine produced in Planta confers protection in mice.
- The envelope G3L protein is essential for entry of vaccinia virus into host cells.
- Epitope-mapping studies define two major neutralization sites on the vaccinia virus extracellular enveloped virus glycoprotein B5R.
- Electrostatic modeling predicts the activities of orthopoxvirus complement control proteins.
- Antibodies against the extracellular enveloped virus B5R protein are mainly responsible for the EEV neutralizing capacity of vaccinia immune globulin.
- Improved protection conferred by vaccination with a recombinant vaccinia virus that incorporates a foreign antigen into the extracellular enveloped virion.
- Working safely with vaccinia virus: laboratory technique and the role of vaccinia vaccination.
- Restoration of complement-enhanced neutralization of vaccinia virus virions by novel monoclonal antibodies raised against the vaccinia virus complement control protein.
- Separate worlds set to collide: smallpox, vaccinia virus vaccination, and human immunodeficiency virus and acquired immunodeficiency syndrome.
- Complement: structure, functions, evolution, and viral molecular mimicry.
- A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge.
- Monkeypox virus and insights into its immunomodulatory proteins.
- A protein-based smallpox vaccine protects mice from vaccinia and ectromelia virus challenges when given as a prime and single boost.
- The identification and characterization of a monoclonal antibody to the vaccinia virus E3 protein.
- Highly attenuated smallpox vaccine protects rabbits and mice against pathogenic orthopoxvirus challenge.
- Activity of vaccinia virus-neutralizing antibody in the sera of smallpox vaccinees.
- Regression of established human papillomavirus type 16 (HPV-16) immortalized tumors in vivo by vaccinia viruses expressing different forms of HPV-16 E7 correlates with...
- Deletion of the vaccinia virus B5R gene encoding a 42-kilodalton membrane glycoprotein inhibits extracellular virus envelope formation and dissemination.
- HIV gag mRNA transfection of dendritic cells (DC) delivers encoded antigen to MHC class I and II molecules, causes DC maturation, and induces a potent human in vitro p...
- Interaction of vaccinia virus complement control protein with human complement proteins: factor I-mediated degradation of C3b to iC3b1 inactivates the alternative comp...
- Vaccinia virus serpin-1 deletion mutant exhibits a host range defect characterized by low levels of intermediate and late mRNAs.
- Characterization of a vaccinia virus-encoded 42-kilodalton class I membrane glycoprotein component of the extracellular virus envelope.
- Vaccinia virus complement-control protein prevents antibody-dependent complement-enhanced neutralization of infectivity and contributes to virulence.
- Reverse guanine phosphoribosyltransferase selection of recombinant vaccinia viruses.
- Functional analysis of vaccinia virus B5R protein: essential role in virus envelopment is independent of a large portion of the extracellular domain.
- Inhibition of the complement cascade by the major secretory protein of vaccinia virus.
- Induction of Plasmodium falciparum transmission-blocking antibodies by recombinant vaccinia virus.
- A macrophage fusion assay for rapid screening of cloned HIV-1 Env using dual recombinant vaccinia viruses expressing distinct RNA polymerases.
- Functional analysis of vaccinia virus B5R protein: role of the cytoplasmic tail.
- A CCR5/CXCR4-independent coreceptor pathway on human macrophages supports efficient SIV env-mediated fusion but not infection: implications for alternative pathways of...
- Induction of Plasmodium falciparum transmission-blocking antibodies by recombinant Pfs25.
- Role of CXCR4 in cell-cell fusion and infection of monocyte-derived macrophages by primary human immunodeficiency virus type 1 (HIV-1) strains: two distinct mechanisms...
- Synthetic peptides from P. falciparum sexual stage 25-kDa protein induce antibodies that react with the native protein: the role of IL-2 and conformational structure o...
- SP6 RNA polymerase containing vaccinia virus for rapid expression of cloned genes in tissue culture.
- Expression of hepatitis E virus putative structural proteins in recombinant vaccinia viruses.
- Concordant utilization of macrophage entry coreceptors by related variants within an HIV type 1 primary isolate viral swarm.
- Human 12(R)-lipoxygenase and the mouse ortholog. Molecular cloning, expression, and gene chromosomal assignment.
- Critical evaluation of smallpox vaccination for laboratory workers.
Schools
Yale University
Temple University Hospital
New Eng Med Center
NihNiaidLvd
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Education
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Tufts Medical Center -
Temple University Hospital -
Yale University School of Medicine
Hospital
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Philadelphia Veterans Affairs Medical Center -
Hospital of the University of Pennsylvania
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