Associate Professor of Anesthesia
Anesthesiology
Dr. Stuart A. Forman, MD
|
|
Give Review
Stuart Forman works in the field of Anesthesiology. He studied medicine at Harvard Medical School. Harvard Medical School is a one of the best medicals schools. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. Stuart Forman has written publications. He has 73 publications published with PubMed. The lastest paper is: 'Novel modulation of a nicotinic receptor channel mutant reveals that the open state is stabilized by ethanol.' Stuart Forman accepts Medicare.
Publications
- Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.
- Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA/1 mice.
- Research at the Harvard Anesthesia Departments.
- Anesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptors.
- Human α1β3γ2L Gamma-Aminobutyric Acid Type A Receptors: High-Level Production and Purification in a Functional State.
- Etomidate Produces Similar Allosteric Modulation in α1β3δ and α1β3γ2L GABAA Receptors.
- Cysteine substitutions define etomidate binding and gating linkages in the α-M1 domain of γ-aminobutyric acid type A (GABAA) receptors.
- A Paradigm Shift from Biophysical to Neurobiological: The Fading Influence of Claude Bernard's Ideas about General Anesthesia.
- The Expanding Genetic Toolkit for Exploring Mechanisms of General Anesthesia.
- Allyl m-Trifluoromethyldiazirine Mephobarbital: An Unusually Potent Enantioselective and Photoreactive Barbiturate General Anesthetic.
- Monod-Wyman-Changeux allosteric mechanisms of action and the pharmacology of etomidate.
- Carboetomidate Inhibits Alpha4/Beta2 Neuronal Nicotinic Acetylcholine Receptors at Concentrations Affecting Animals.
- Two etomidate sites in α1β2γ2 γ-aminobutyric acid type A receptors contribute equally and noncooperatively to modulation of channel gating.
- Mutations in the GABAA receptor that mimic the allosteric ligand etomidate.
- An Allosteric Coagonist Model for Propofol Effects on ?1?2?2L ?-Aminobutyric Acid Type A Receptors.
- p-(4-Azipentyl)propofol: A Potent Photoreactive General Anesthetic Derivative of Propofol.
- Pharmacological Studies of Methoxycarbonyl Etomidate's Carboxylic Acid Metabolite.
- Clinical and molecular pharmacology of etomidate.
- Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.
- Molecular approaches to improving general anesthetics.
- p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels.
- High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAA and serotonin receptors.
- Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function.
- Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity.
- Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression.
- Time-resolved photolabeling of the nicotinic acetylcholine receptor by [3H]azietomidate, an open-state inhibitor.
- Tryptophan mutations at azi-etomidate photo-incorporation sites on alpha1 or beta2 subunits enhance GABAA receptor gating and reduce etomidate modulation.
- Protein kinase C modulates inactivation of Kv3.3 channels.
- Photo-activated azi-etomidate, a general anesthetic photolabel, irreversibly enhances gating and desensitization of gamma-aminobutyric acid type A receptors.
- General anesthetics and molecular mechanisms of unconsciousness.
- Differential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic model.
- Photoactivated 3-azioctanol irreversibly desensitizes muscle nicotinic ACh receptors via interactions at alphaE262.
- Correlating the clinical actions and molecular mechanisms of general anesthetics.
- Of mice and nematodes.
- Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on...
- Gating-enhanced accessibility of hydrophobic sites within the transmembrane region of the nicotinic acetylcholine receptor's {delta}-subunit. A time-resolved photolabe...
- Classic benzodiazepines modulate the open-close equilibrium in alpha1beta2gamma2L gamma-aminobutyric acid type A receptors.
- Gating allosterism at a single class of etomidate sites on alpha1beta2gamma2L GABA A receptors accounts for both direct activation and agonist modulation.
- Mechanisms of actions of inhaled anesthetics.
- 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling lig...
- Modulation of GABA(A) receptor function by nonhalogenated alkane anesthetics: the effects on agonist enhancement, direct activation, and inhibition.
- Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors.
- Nonhalogenated anesthetic alkanes and perhalogenated nonimmobilizing alkanes inhibit alpha(4)beta(2) neuronal nicotinic acetylcholine receptors.
- n-Alkanols and halothane inhibit red cell anion transport and increase band 3 conformational change rate.
- A novel missense mutation in SLC34A3 that causes hereditary hypophosphatemic rickets with hypercalciuria in humans identifies threonine 137 as an important determinant...
- Identification, functional characterization, and developmental expression of two nonallelic parathyroid hormone (PTH)/PTH-related peptide receptor isoforms in Xenopus ...
- Value of radionuclide rest and exercise left ventricular ejection fraction in assessing survival of patients after thrombolytic therapy for acute myocardial infarction...
- Alternative mechanism for pathogenesis of an inherited epilepsy by a nicotinic AChR mutation.
- Ethanol increases agonist affinity for nicotinic receptors from Torpedo.
- Molecular sites of anesthetic action in postsynaptic nicotinic membranes.
- Procaine rapidly inactivates acetylcholine receptors from Torpedo and competes with agonist for inhibition sites.
- High acetylcholine concentrations cause rapid inactivation before fast desensitization in nicotinic acetylcholine receptors from Torpedo.
- Homologous mutations on different subunits cause unequal but additive effects on n-alcohol block in the nicotinic receptor pore.
- General anesthetic and specific effects of ethanol on acetylcholine receptors.
- Direct interactions of anesthetics and nonanesthetics with the nicotinic acetylcholine receptor pore.
- Is agonist self-inhibition at the nicotinic acetylcholine receptor a nonspecific action?
- Short chain and long chain alkanols have different sites of action on nicotinic acetylcholine receptor channels from Torpedo.
- The nicotinic acetylcholine receptor in its membrane environment.
- A hydrophobic photolabel inhibits nicotinic acetylcholine receptors via open-channel block following a slow step.
- Nonanesthetic volatile drugs obey the Meyer-Overton correlation in two molecular protein site models.
- Nicotinic receptor pore mutations create a sensitive inhibitory site for ethanol.
- Actions of pentobarbital enantiomers on nicotinic cholinergic receptors.
- Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic.
- The gamma subunit determines whether anesthetic-induced leftward shift is altered by a mutation at alpha1S270 in alpha1beta2gamma2L GABA(A) receptors.
- Butanol effects on gamma-amino butyric acid concentration-responses in human alpha1beta2gamma2L gamma-amino butyric acid type A receptors with a mutation at alpha1S270.
- Nonhalogenated alkane anesthetics fail to potentiate agonist actions on two ligand-gated ion channels.
- The n-alcohol site in the nicotinic receptor pore is a hydrophobic patch.
- Novel modulation of a nicotinic receptor channel mutant reveals that the open state is stabilized by ethanol.
- Stereoselectivity of channel inhibition by secondary alkanol enantiomers at nicotinic acetylcholine receptors.
- A discrete site for general anesthetics on a postsynaptic receptor.
- Mechanisms of general anesthesia: from molecules to mind.
- Iatrogenic risk factors for Alzheimer''s disease: surgery and anesthesia.
Schools
Harvard Medical School
Beth Israel Deaconess Medical Center
Massachusetts General Hospital
Doctors Specialties
- Anesthesiology
Accepted Insurances
Education
-
Massachusetts General Hospital -
Beth Israel Deaconess Medical Center -
Harvard Medical School
Hospital
-
Massachusetts General Hospital
Helpful Reviews
Similar Doctors
|
|
Dr. Cynthia S. Tung, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Anasuya Vasudevan, MB
This Doctor is OpenDoctor Recommended.
|
|
|
Shahzad Shaefi, MB
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Rebecca J. Spencer, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Thomas M. Romanelli, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Jared Feinman, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Daniel Y. Chen, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Brian M. Osman, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Simon Gelman, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Patrick M. Newman, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Edna A. Butaney, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Virgil S. Manica, MD
This Doctor is OpenDoctor Recommended.
|