Assistant Professor of Medicine, Beth Israel Deaconess Medical Center
Nephrology
Dr. Stewart H. Lecker, MD
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Doctor Stewart H. Lecker, MD practices Nephrology. He attended David Geffen School of Medicine at UCLA. David Geffen School of Medicine at UCLA is a top medical university. David Geffen School of Medicine at UCLA has a rank of 13 in research and a 7 in primary care He received 2 awards: "Meaningful Use Stage 1 Certification" and "Fellow (ASNF)". Stewart Lecker is a published doctor and has 46 publications published. The lastest was: 'Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states.' Stewart H. Lecker accepts Medicare payments and is registered with Medicare.gov.
Publications
- Analysis of Skeletal Muscle Gene Expression Patterns and the Impact of Functional Capacity in Patients with Systolic Heart Failure.
- Suppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes.
- Proteolysis in illness-associated skeletal muscle atrophy: from pathways to networks.
- Proteolysis by the ubiquitin-proteasome system and Kidney disease.
- Mechanisms involved in 3',5'-cyclic adenosine monophosphate-mediated inhibition of the ubiquitin-proteasome system in skeletal muscle.
- Given the science on malnutrition, how does the clinician respond? Practical lessons for and application to the dialysis patient.
- Mechanisms underlying skeletal muscle weakness in human heart Failure: alterations in single fiber myosin protein content and function.
- Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect.
- Calpain activity and muscle wasting in sepsis.
- The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity.
- FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.
- Atrophy-related ubiquitin ligases atrogin-1 and MuRF-1 are associated With uterine smooth muscle involution in the postpartum period.
- Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic Diseases.
- PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription.
- Protein degradation by the ubiquitin-proteasome pathway in normal and Disease states.
- Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.
- Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression.
- TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k.
- Patterns of gene expression in atrophying skeletal muscles: Response to food deprivation.
- Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and Disease states.
- The N-end rule pathway catalyzes a major fraction of the protein degradation in skeletal muscle.
- ProOmpA contains secondary and tertiary structure prior to translocation and is shielded from aggregation by association With SecB protein.
- Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats.
- Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy.
- Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.
- Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide.
- Ca2+-free calmodulin and calmodulin damaged by in vitro aging are selectively degraded by 26 S proteasomes Without ubiquitination.
- Upregulation of RGS7 may contribute to tumor necrosis factor-induced changes in central nervous function.
- The binding cascade of SecB to SecA to SecY/E mediates preprotein targeting to the E. coli plasma membrane.
- Problems related to the coding of multiple primary cancers.
- Epidemiology of classic Kaposi's sarcoma in Denmark between 1970 and 1992.
- [Kaposi sarcoma. An epidemiological perspective].
- ProOmpA is stabilized for membrane translocation by either purified E. coli trigger factor or canine signal recognition particle.
- Export of prepro-alpha-factor from Escherichia coli.
- Three pure chaperone proteins of Escherichia coli--SecB, trigger factor and GroEL--form soluble complexes With precursor proteins in vitro.
- Atrogin-1 affects muscle protein synthesis and degradation when energy Metabolism is impaired by the antidiabetes drug berberine.
- Dexamethasone and corticosterone induce similar, but not identical, muscle wasting Responses in cultured L6 and C2C12 myotubes.
- The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling.
- Electrolyte-free water clearance: a key to the diagnosis of hypernatremia in resolving Acute renal failure.
- Ubiquitin-protein ligases in muscle wasting: multiple parallel pathways?
- Slowing muscle atrophy: putting the brakes on protein breakdown.
- Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL.
- Molecular basis for statin-induced muscle toxicity: implications and possibilities.
- Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms.
- Ubiquitin-protein ligases in muscle wasting.
Schools
David Geffen School Of Medicine At UCLA University Of California Los Angeles
UCLA Center Health Scis
Beth Israel Hospital
Procedures Preformed
- End-Stage Renal Disease Related Services
- Hemodialysis
- Peritoneal Dialysis
Conditions Treated
- Acidosis
- Acute Kidney Failure
- Amyloidosis
- Calcium Metabolism Disorders
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Doctors Specialties
- Nephrology
Accepted Insurances
Awards
- Meaningful Use Stage 1 Certification
- Fellow (ASNF)
Education
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Beth Israel Deaconess Medical Center -
UCLA Medical Center -
David Geffen School of Medicine at UCLA
Hospital
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Beth Israel Deaconess Medical Center
Drug Facts
| NPI NUMBER | 1184661134 | |
| NPPES Provider LastName | LECKER | |
| NPPES Provider FirstName | STEWART | |
| NPPES Provider ZIPCode | 02215 | |
| NPPES Provider State | MA | |
| Specialty Description | Nephrology | |
| Total Claim Count | 826.0 | |
| Distinct Opioid Count | 1.0 | |
| Opioid Claim Count | 14.0 | |
| Percent Opioid Claims | 1.69 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1184661134 |
| Last Name Of The Provider | LECKER |
| First Name Of The Provider | STEWART |
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