Professor, Medicine, Weill Cornell Med College

Internal Medicine

Steven Goldring practices Internal Medicine. He researched medicine at Washington University School of Medicine in St. Louis. Steven Goldring has written publications. He has 99 publications published with PubMed. The lastest publication is: 'Immortalization of osteoclast precursors by targeting Bcl -XL and Simian virus 40 large T antigen to the osteoclast lineage in transgenic mice.'

Publications

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• Inflammatory signaling induced bone loss.
• Simvastatin prodrug micelles target fracture and improve healing.
• Early Diagnosis of Orthopedic Implant Failure Using Macromolecular Imaging Agents.
• Macromolecular prodrug of dexamethasone prevents particle-induced peri-implant osteolysis with reduced systemic side effects.
• The influence of synovial inflammation and hyperplasia on symptomatic outcomes up to 2 years post-operatively in patients undergoing partial meniscectomy.
• Beyond the decade: strategic priorities to reduce the burden of musculoskeletal disease.
• Osteoimmunology and bone homeostasis: relevance to spondyloarthritis.
• In vivo cyclic compression causes cartilage degeneration and subchondral bone changes in mouse tibiae.
• Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues.
• Bone remodelling in inflammatory arthritis.
• Development of polymeric nanocarrier system for early detection and targeted therapeutic treatment of peri-implant osteolysis.
• Orthopedic wear debris mediated inflammatory osteolysis is mediated in part by NALP3 inflammasome activation.
• Negative regulation of osteoclast precursor differentiation by CD11b and beta2 integrin-B-cell lymphoma 6 signaling.
• Frontiers in osteoarthritis: executive summary of the scientific meeting: executive summary of the scientific meeting.
• Reaching consensus and highlighting future directions for research: the osteoarthritis summit breakout sessions.
• Cellular response to prosthetic wear debris differs in rheumatoid versus non-rheumatoid arthritis patients.
• Identification of a central role for complement in osteoarthritis.
• The bone, the joints and the balm of gilead.
• Early Detection and Treatment of Wear Particle-Induced Inflammation and Bone Loss in a Mouse Calvarial Osteolysis Model Using HPMA Copolymer Conjugates.
• Bone matrix regulates osteoclast differentiation and annexin A8 gene expression.
• Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms.
• Synovial inflammation in patients undergoing arthroscopic meniscectomy: Molecular characterization and relationship with symptoms.
• The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate.
• Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis.
• Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors.
• The effect of paraformaldehyde fixation on the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) measurement.
• Targeting bone remodeling for the treatment of osteoporosis: summary of the proceedings of an ASBMR workshop.
• Needs and opportunities in the assessment and treatment of osteoarthritis of the knee and hip: the view of the rheumatologist.
• Role of bone in osteoarthritis pathogenesis.
• The role of bone in osteoarthritis pathogenesis.
• PU.1 and NFATc1 mediate osteoclastic induction of the mouse beta3 integrin promoter.
• Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction.
• Eating bone or adding it: the Wnt pathway decides.
• Role of macrophages in LPS-induced osteoblast and PDL cell apoptosis.
• The role of cytokines in cartilage matrix degeneration in osteoarthritis.
• Bisphosphonates: environmental protection for the joint?
• ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation.
• MEK/ERK and signal transducer and activator of transcription signaling pathways modulate oncostatin M-stimulated CCL2 expression in human osteoblasts through a common ...
• Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo.
• Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nucl...
• Nitric oxide promotes infectious bone resorption by enhancing cytokine-stimulated interstitial collagenase synthesis in osteoblasts.
• Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced...
• The role of adsorbed endotoxin in particle-induced stimulation of cytokine release.
• Pathogenesis of bone erosions in rheumatoid arthritis.
• Pathogenesis of bone lesions in rheumatoid arthritis.
• Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium.
• Microscopic metallic wear and tissue response in failed titanium hallux metatarsophalangeal implants: two cases.
• Histopathological characterization of corrosion product associated adverse local tissue reaction in hip implants: a study of 285 cases.
• Bone and cartilage in osteoarthritis: is what''s best for one good or bad for the other?
• Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy.
• Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis.
• Periarticular bone changes in rheumatoid arthritis: pathophysiological implications and clinical utility.
• A novel promoter regulates calcitonin receptor gene expression in human osteoclasts.
• NFATc1 regulation of the human beta3 integrin promoter in osteoclast differentiation.
• The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis.
• Gene expression clustering using self-organizing maps: analysis of the macrophage response to particulate biomaterials.
• The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes.
• Rheumatic diseases: the effects of inflammation on bone.
• Bone and joint destruction in rheumatoid arthritis: what is really happening?
• Adenosine A(1) receptors regulate bone resorption in mice: adenosine A(1) receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone lo...
• Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor.
• Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease.
• Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications.
• Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the calcitonin receptor gene.
• The role of cell-substrate interaction in regulating osteoclast activation: potential implications in targeting bone loss in rheumatoid arthritis.
• Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis.
• Targeting the giant cell tumor stromal cell: functional characterization and a novel therapeutic strategy.
• Expression of two human skeletal calcitonin receptor isoforms cloned from a giant cell tumor of bone. The first intracellular domain modulates ligand binding and signa...
• Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line.
• Tissue-specific and ubiquitous promoters direct the expression of alternatively spliced transcripts from the calcitonin receptor gene.
• Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin. Evidence for a common pattern of ligand-receptor interaction.
• Expression cloning and characterization of a porcine renal calcitonin receptor.
• A cloned porcine renal calcitonin receptor couples to adenylyl cyclase and phospholipase C.
• Cellular mechanisms and the role of cytokines in bone erosions in rheumatoid arthritis.
• Calcitonin-dependent down-regulation of the mouse C1a calcitonin receptor in cells of the osteoclast lineage involves a transcriptional mechanism.
• Multinucleated cells elicited in response to implants of devitalized bone particles possess receptors for calcitonin.
• NFATc1 directly induces the human beta3 integrin gene in osteoclast differentiation.
• Pathogenesis of bone and cartilage destruction in rheumatoid arthritis.
• Angiopoietin-1 is expressed in the synovium of patients with rheumatoid arthritis and is induced by tumour necrosis factor alpha.
• TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis.
• Design, synthesis and utility of novel benzophenone-containing calcitonin analogs for photoaffinity labeling the calcitonin receptor.
• The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption.
• Role of cell-matrix interactions in osteoclast differentiation.
• An interleukin 1 beta point mutant demonstrates that jun/fos expression is not sufficient for fibroblast metalloproteinase expression.
• Molecular analysis of chromium and cobalt-related toxicity.
• Evaluation of connective tissue cell responses to orthopaedic implant materials.
• Expression cloning of an adenylate cyclase-coupled calcitonin receptor.
• Dual proline labeling protocol for individual "baseline" and "response" biosynthesis measurements in human articular cartilage.
• Immortalization of osteoclast precursors by targeting Bcl -XL and Simian virus 40 large T antigen to the osteoclast lineage in transgenic mice.
• Multinucleated cells in pigmented villonodular synovitis and giant cell tumor of tendon sheath express features of osteoclasts.
• Production of cytokines around loosened cemented acetabular components. Analysis with immunohistochemical techniques and in situ hybridization.
• The final pathogenetic steps in focal bone erosions in rheumatoid arthritis.
• Recommendations for the use of preclinical models in the study and treatment of osteoarthritis.
• Phospholipase D- and protein kinase C isoenzyme-dependent signal transduction pathways activated by the calcitonin receptor.
• Formation of a synovial-like membrane at the bone-cement interface. Its role in bone resorption and implant loosening after total hip replacement.
• Multiple domains interacting with Gs in the porcine calcitonin receptor.
• Heparin modulates intracellular cyclic AMP in human trabecular bone cells and adherent rheumatoid synovial cells.
• Characterization of the structural and functional properties of cloned calcitonin receptor cDNAs.

Schools

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• Washington Center School of Medicine

Doctors Specialties

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• Rheumatology
• Internal Medicine

Accepted Insurances

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Education

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• Massachusetts General Hospital
• Brigham and Women's Hospital
• Washington University School of Medicine in St. Louis

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